賽默飛世爾科技 (TMO) 2017 Q3 法說會逐字稿

Good morning, ladies and gentlemen, and welcome to the Thermo Fisher Scientific 2017 Third Quarter Conference Call.

(Operator Instructions)

I would like to introduce our moderator for the call, Mr. Kenneth Apicerno, Vice President, Investor Relations.

Mr. Apicerno, you may begin your call.

Good morning, and thank you for joining us.

On the call with me today is Marc Casper, our President and Chief Executive Officer; and Stephen Williamson, Senior Vice President and Chief Financial Officer.

Please note, this call is being webcast live and will be archived on the Investors section of our website, thermofisher.com under the heading Webcast and Presentations until November 3, 2017.

A copy of the press release of our third quarter 2017 earnings and future expectations is available on the Investors section of our website under the heading Financial Results.

So before we begin, let me briefly cover our safe harbor statement.

Various remarks that we may make about the company's future expectations, plans and prospects constitute forward-looking statements for purposes of the safe harbor provisions under the Private Securities Litigation Reform Act of 1995.

Actual results may differ materially from those indicated by these forward-looking statements as a result of various important factors, including those discussed in the company's quarterly report on Form 10-Q for the quarter ended July 1, 2017, under the caption Risk Factors, which is on file with the Securities and Exchange Commission and also available on the Investors section of our website under the heading SEC Filings.

While we may elect to update forward-looking statements at some point in the future, we specifically disclaim any obligation to do so, even if our estimates change.

Therefore, you should not rely on these forward-looking statements as representing our views as of any date subsequent to today.

Also during this call, we'll be referring to certain financial measures not prepared in accordance with generally accepted accounting principles, or GAAP.

A reconciliation of these non-GAAP financial measures to the most directly comparable GAAP measures is available in the press release of our third quarter 2017 earnings and future expectations and also in the Investors section of our website under the heading Financial Information.

So with that, I'll now turn the call over to Marc.

Thank you, Ken.

Good morning, everyone.

Thanks for joining us today for our Q3 call.

I'm pleased to report that Q3 was another excellent quarter for Thermo Fisher Scientific.

We achieved strong growth on both the top and bottom line, thanks to sharp execution by our team.

We had a number of developments in the quarter that strengthened our leadership and innovation and in emerging markets.

And we significantly enhanced our customer value proposition by adding new capabilities through the acquisition of Patheon, which we were able to complete earlier than expected.

With an excellent 9 months behind us, we're well positioned to achieve our growth goals for the year.

So let me start with a quick overview of our Q3 financial highlights.

First, we delivered another quarter of strong adjusted EPS performance, achieving a 14% increase to $2.31 per share.

Our revenue in Q3 also grew 14% year-over-year.

Our adjusted operating income increased 13%.

Before I turn to our end markets, I wanted to acknowledge the tremendous effort of our teams.

The natural disasters during the past couple of months have been unprecedented, and our teams have managed through very effectively.

I've been inspired how our -- by how our colleagues across the company have stepped in to offer their support in many different ways from both a humanitarian and an operational perspective.

For us, the most significant impact was in Puerto Rico.

About 700 colleagues and their families are located on the island and we were relieved to learn that they were all safe.

Even with tough challenges at home, it was humbling to see colleagues return to work, focused on doing everything they could to meet customer requirements.

It reinforced our culture of intensity and involvement, which is the foundation for how we work every day, but really stands out in times like these.

Our legacy Patheon site in Manatí, Puerto Rico is the only one still experiencing disruption, but we're making steady progress in getting the facility back to full operation.

Now let me provide you some color on our Q3 performance relative to our key end markets.

Starting with pharma and biotech, we grew in the mid-single digits in Q3.

Our chromatography and mass spectrometry and biosciences businesses performed well.

We also had strong growth in our research and safety market channel.

Our value proposition for these customers remain a key competitive advantage for us.

And we continue to build on our leading position.

Diagnostics and healthcare grew in the low single digits, in line with what we've been seeing all year, with good growth in our transplant and immunodiagnostic businesses.

In academic and government, we were pleased to report mid-single-digit growth, driven by strong performance in Europe and China.

Last, in industrial and applied, we continue to benefit from increasing global demand and grew here in the mid-single digits.

We saw a particular strength across our Analytical Instrument businesses in Asia Pacific.

We also continue to make excellent progress in setting Thermo Fisher up for an even stronger future.

As you know, the 3 elements of our growth strategy are: developing high-impact innovative new products; leveraging our scale in Asia Pacific and emerging markets; and delivering a unique value proposition to our customers.

I emphasize these each quarter because it illustrates our commitment to a consistent and well-defined strategy that continues to strengthen our competitive position.

So with that, I'll get into our Q3 highlights starting with innovation.

First, we launched 4 new Thermo Scientific products at the Microscopy & Microanalysis meeting in early August to strengthen our leadership in electron microscopy.

For materials science applications, we launched 2 new scanning electron microscopes, the Quattro and the Talos F200i, to help scientists advance nanomaterials research.

And for life sciences applications, we launched the Krios G3i and Glacios Cryo-EM systems to make the analysis of proteins and other biomolecular structures faster and easier.

Our goal is to bring Cryo-EM to a broader range of scientists and raise the standards of performance and workflow automation.

We were also very pleased to learn in early October that the 3 scientists who won the Nobel Prize in Chemistry worked with our Cryo-EM systems.

As a result of their efforts, scientists can now routinely produce high-resolution 3D images of protein structures.

These developments can lead to a better understanding of biological function and, ultimately, to new therapies.

As you know, we gained these groundbreaking capabilities through our acquisition of FEI, which is part of analytical instruments offering.

We surpassed the 1-year anniversary of this transaction in late September, and the teams are doing a great job with the integration.

The business continues to perform extremely well, and we're on track to achieve our synergy targets.

Another notable launch in our Analytical Instruments business was our new line of Thermo Scientific air quality monitors called the iQ Series.

These new instruments are designed to help global customers in the power industry and government agencies more easily gather and manage critical air quality data.

The iQ Series platform includes mobile applications for remote monitoring and control as well as wireless connectivity and enhanced services.

I also want to quickly mention that our new mass spectrometry systems launched at ASMS in June, including the Q Exactive HF-X and our new Altis and Quantis triple quads, have been exceptionally well received.

Our innovative mass spec platforms are really resonating with customers, working in both research and applied markets.

Last, I'll touch on significant development in our Life Sciences Solutions business.

Our Dynabeads technology was integral to the first FDA-approved gene therapy, which will be used to treat a specific form of leukemia in children and young adults.

These magnetic beads are able to isolate, activate and amplify T-cells that have been genetically programmed to identify and fight cancer cells in individual patients.

This groundbreaking innovation in gene therapy was the result of our longstanding collaboration with Novartis.

It's another great example of our commitment to advance precision medicine by partnering with leaders in industry, government and academia.

Turning to our second key growth driver, Asia Pacific and emerging markets.

We continued our strong performance in the region in Q3.

China again led the way with growth in the high teens.

And we also had strong results in South Korea and India.

In China, we continue to build on our leading presence with the opening of our Precision Medicine Customer Experience Center in Guangzhou in the quarter.

The facility is an impressive showcase for our wide range of workflow solutions to advance research in genomics, proteomics and metabolomics.

And it also serves as a hub for customer training, collaboration and application development.

This milestone is a continuation of our strategic collaboration with the Guangzhou government.

Earlier this year, we kicked off another collaboration with the Mab-Venture Pharmaceutical to jointly establish a new center to accelerate the development of biopharmaceuticals.

Guangzhou is at the heart of healthcare innovation in China, and these are good examples of our in-China, for-China strategy to introduce new capabilities geared specifically to local customers.

Our third growth driver is our customer value proposition, and we continue to invest significantly to enhance our offering and strengthen our competitive position.

As you know, in late August, we closed our acquisition of Patheon, which was ahead of the timeline we communicated when we announced the transaction back in May.

We welcomed 9,000 new colleagues to our team, and it was great to be at the Greenville, North Carolina site to participate on the day 1 event.

I've been in a number of the facilities.

The operations are impressive.

And the teams are energized to take the great business they built to the next level as part of Thermo Fisher.

We're only 2 months into the integration, but we're already more excited about the opportunities we have to become an even stronger partner for our pharma and biotech customers.

As we communicated previously, we expect to realize total synergies of approximately $120 million by year 3 following the close.

This would consist of approximately $90 million of cost synergies and about $30 million of adjusted operating income benefit from revenue-related synergies.

It's early in the integration, but we're off to a great start.

And we look forward to updating you on our progress over time.

So it was another active year for capital deployment.

As you know, in addition to buying back our stock, we continue to strengthen our strategic position by completing a number of acquisitions, with Patheon being the largest this year.

In terms of our short-term capital deployment priorities, they're twofold.

First, with the close of the Patheon acquisition, we're already paying down debt.

And second, the manner in which we financed the Patheon acquisition also gives us the capacity to continue to capitalize on M&A opportunities.

Our pipeline is active, and we continue to evaluate new opportunities to create shareholder value.

Let me now turn to our guidance for 2017.

As you saw in our press release, we're raising both our revenue and adjusted EPS guidance for the full year.

This reflects the addition of Patheon, the strength of our operational performance and our ongoing commitment to delivering the benefits of a more favorable FX environment.

Stephen will cover the details, but at a high level, we're raising our revenue guidance to a new range of $20.50 billion to $20.66 billion, which would now result in 12% to 13% growth over 2016.

In terms of our adjusted EPS, we're raising our guidance to a new range of $9.29 to $9.38 for 2017, which also represents 12% to 13% growth year-over-year.

Before I turn the call over to Stephen, let me summarize our key takeaways from Q3.

We delivered another excellent quarter financially and operationally.

We completed our acquisition of Patheon, and the integration is off to a strong start.

We've made terrific progress in the past 9 months.

And we're on track to deliver another excellent year.

With that, I'll now hand the call over to our CFO, Stephen Williamson.

Stephen.

Thanks, Marc, and good morning, everyone.

I'll take you through an overview of our third quarter results for the total company.

And then I'll provide some color on our 4 business segments and wrap up with an updated 2017 guidance.

Before I get into the details, let me remind you that our results now reflect the addition of the Patheon acquisition, which we closed on August 29.

Patheon's results are now part of the Laboratory Products and Services Segment.

So with that, let me start with a high-level view of how the third quarter performed versus our expectations at the time of the last earnings call.

As you saw in our press release, we delivered a very strong quarter with 5% organic growth in Q3, which was above the midpoint of our previous guidance range and was driven by strong operational execution.

We were also able to deliver $0.11 more adjusted earnings per share in Q3 than we'd assumed at the midpoint of our previous guidance.

This was driven by 4 factors of roughly equal magnitude: the pull-through on the incremental organic growth; a more favorable foreign exchange environment; the timing of our discrete tax planning actions; and the contributions from Patheon.

And let me give you more color on the quarter starting with our total company financial performance.

As you saw in our press release, we grew adjusted EPS in Q3 by 14% to $2.31.

GAAP EPS was $1.34, up 13% from Q3 last year.

On the top line, our reported revenue grew 14% year-over-year.

The components of our Q3 reported revenue included 5% organic growth, 8% growth from acquisitions and a 1% tailwind from foreign exchange.

Looking at growth by geography in Q3.

Europe grew in the mid-single digits.

North America grew in the low single digits.

Asia Pacific grew in the low double digits, including high teens growth in China.

And finally, rest of the world grew in the mid-single digits.

Turning to our operational performance.

Q3 adjusted operating income increased 13% and adjusted operating margin was 22.9%, which contracted 10 basis points from Q3 of last year.

Patheon was a 40 basis points dilutive to margins in the quarter, and FX a further 10 basis points dilution.

As a reminder, Patheon is a scale acquisition with gross margins and adjusted operating income margins lower than the company average.

So as we incorporate the results of Patheon into our financials over the first 12 months, it will have a dilutive impact in year-over-year margin expansion.

The rest of the business saw good margin expansion, driven by our PPI Business System and volume leverage, partially offset by unfavorable business mix and strategic investments.

Adjusted gross margin came in at 48.4% in Q3.

This represents a contraction of 50 basis points from the prior year.

The combination of Patheon and FX lowered gross margins by 100 basis points in the quarter.

The rest of the business saw a good gross margin expansion, driven by very strong contributions from our PPI Business System, partially offset by business mix.

Adjusted SG&A in the quarter was 21.2% of revenue, which is 60 basis points favorable to Q3 2016.

And R&D expense came in at 4.3% of revenue.

R&D as a percent of our manufacturing revenue was 6.6%, up 50 basis points over Q3 2016.

Looking at our results below the line.

Net interest expense was $132 million, up $29 million from Q3 2016, mainly as a result of our incremental debt related to the capital deployment actions this year.

Adjusted other income and expense was a net income of $7 million within the quarter, which is $6 million favorable versus Q3 2016, driven primarily by nonoperating FX gains.

Our adjusted tax rate in Q3 was 11.8%, which is 130 basis points lower than last year due to our tax planning activities and the impact of Patheon.

The timing of discrete tax planning actions within Q3 and Q4 of 2017 is different versus our previous guidance.

As a result, the Q3 tax rate is slightly lower than previously expected.

And the Q4 tax rate will be slightly higher with no net impact expected on the year due to the shift in timing.

And average diluted shares were 399.6 million, up 2.2 million year-over-year due to the completion of the recent equity offering and option dilution, partially offset by previous share buybacks.

Turning to cash flow and the balance sheet.

Cash flow from continuing operations for the first 9 months of the year was $2.15 billion.

And free cash flow was $1.85 billion after deducting net capital expenditures of $290 million.

Free cash flow is $85 million higher than the same period last year and approximately $200 million -- and includes approximately $200 million of onetime cash payments related to the Patheon acquisition.

We ended the quarter with $745 million in cash and investments.

And similar to previous quarters, we paid $60 million of dividends in Q3.

Our total debt at the end of Q3 was $22 billion, up $5.2 billion sequentially from Q2 as a result of the financing related to the Patheon acquisition.

Our leverage ratio at the end of the quarter was 4.4x total debt to adjusted EBITDA on a reported basis and 4.1x on a pro forma basis, which is in line with our expectations.

And wrapping up my comments in our total company performance, our trailing 12 months' adjusted ROIC was 9.8%, flat versus prior year.

This represents approximately 100 basis points of operational improvement over Q3 2016, in line with our expectations.

And let me give you some color on the revenue and operational performance of our 4 business segments.

Starting with the Life Sciences Solutions Segment, reported revenue grew 5% and organic revenue increased 4% in Q3.

Our Biosciences business delivered another strong quarter of growth.

Q3 adjusted operating income in the segment increased 17% and adjusted operating margin grew 320 basis points year-over-year to 32.8%.

In the quarter, we saw a very strong productivity, volume pull-through and positive business mix, partially offset by strategic investments.

In the Analytical Instruments Segment, reported revenue increased 32% in Q3 and organic revenue growth was 11%.

This segment includes our FEI electron microscopy product line, which is part of our materials science business.

In the quarter, we had strong growth in our chromatography and mass spec and our materials science businesses.

We also continued to see growth in our chemical analysis business.

Q3 adjusted operating income in Analytical Instruments grew 35%.

And adjusted operating margin was 21.6%, up 40 basis points year-over-year.

In the quarter, adjusted operating margin benefited from our PPI Business System, volume pull-through and acquisitions, partially offset by strategic investments and foreign exchange.

Turning to Specialty Diagnostics Segment.

In Q3, revenue grew 6% and organic revenue growth was 4%.

We saw good organic growth contributions from all our businesses in the segment in Q3, with particularly strong growth in our immunodiagnostics and transplant diagnostics businesses.

Adjusted operating income increased (technical difficulty) and adjusted operating margin was 25.9%, which represents a contraction of 90 basis points in Q3 of the prior year.

Adjusted operating margin was positively affected by volume and productivity.

However, this is more than offset by strategic investments and business mix.

Finally, in the Laboratory Products and Services Segment, which now includes the Patheon acquisition, Q3 reported revenue increased 15% and organic revenue growth was 3%.

Our channel business once again delivered a strong growth in the quarter.

Adjusted operating income in the segment increased 1% and adjusted operating margin was 12.6%, down 170 basis points (technical difficulty) . Adjusted operating margin benefited from strong productivity in volume leverage.

However, as expected, this is more than offset by the impact of unfavorable business mix, driven by our clinical trials business and by strategic investments.

As a reminder, the clinical trials business was affected by the discontinuation of a large Phase III clinical trial in late 2016, and the impact will sunset by the end of Q4.

With that, I'll now move on to our full year 2017 guidance.

As you saw in our press release, we are raising the revenue and adjusted earnings per share guidance.

Let me walk you through the details, starting with revenue.

The midpoint of our revenue guidance is increasing $780 million to reflect $670 million from Patheon, an $80 million improvement in foreign exchange and a $25 million increase in organic revenue as a result of our operating performance in Q3.

The full year organic growth outlook is, therefore, $25 million higher than our previous guidance, but it did not change the round for the full year, so we still expect 4% organic growth for 2017.

On adjusted earnings per share, we're increasing the midpoint of our adjusted EPS guidance by $0.12.

This includes $0.05 impact from Patheon, $0.04 improved operational performance and $0.03 from a less adverse FX environment.

And finally, with 3 quarters of strong operational performance behind us, we're narrowing our revenue guidance range to $160 million and narrowing our adjusted earnings per share range to $0.09.

As Marc mentioned, Hurricane Maria caused widespread damage to Puerto Rico last month, and our thoughts and prayers are with the people affected.

We have 3 operational sites on the island.

The largest, our legacy Patheon site, is still offline.

We're working with our customers to get that site back online as soon as possible.

We currently estimate the impact of the site being offline to be approximately $0.05 of adjusted earnings per share, and that is factored into the guidance I just outlined.

So despite this headwind, we're still able to increase guidance at the midpoint by $0.12, which indicates that we're executing very well.

To sum up the guidance changes.

The increased 2017 revenue guidance is now a range of $20.5 billion to $20.66 billion, which would represent 12% to 13% growth versus 2016.

We expect acquisitions to contribute just under 9% to our reported revenue growth in 2017.

And FX is expected to be a year-over-year headwind of $10 million, a negligible impact on growth.

In terms of adjusted earnings per share, our increased 2017 guidance is now a range of $9.29 to $9.38 with a midpoint of $9.335.

This represents growth of 12% to 13% versus 2016.

We now expect a headwind from foreign exchange of $0.12 for the year.

Excluding the impact of FX, this would represent adjusted earnings per share growth of 14% to 15%.

A few other details behind the revised 2017 guidance.

As I mentioned earlier, Patheon's margin profile is lower than the average for the company, so it will be dilutive to the overall operating margins for the first 12 months.

Our revised guidance now assumes that we will deliver 20 basis points of adjusted operating margin expansion in 2017.

Excluding Patheon, the revised guidance is 60 basis points of expansion, which is slightly higher than our previous guidance.

Net interest expense has increased $30 million from our previous guidance to $510 million as a result of the financing of the Patheon acquisition.

And we're forecasting our adjusted income tax rate to be 13% for the year, which is a 30 basis points reduction from our previous guidance due to the positive impact of the Patheon acquisition.

We've completed $750 million of share buybacks this year, all in the first half.

And at this point, we do not expect any additional buybacks in 2017.

We continue to assume we'll return approximately $240 million of capital to shareholders through dividends in 2017.

Our guidance does not include any future acquisitions or divestitures.

And full year average diluted shares are now estimated to be 398 million, which is a 4 million increase from the previous guidance due to the completion of the recent equity offering.

Q4 average diluted shares are estimated to be 404.5 million.

We're assuming net capital expenditures to be approximately $500 million, no change from the previous guidance.

And with respect to free cash flow, as I mentioned earlier, we've incurred approximately $200 million of onetime cash payments related to the Patheon acquisition.

This is being offset by improved operational cash flow, including a small benefit from the Patheon business, so we continue to expect to generate about $3.15 billion of free cash flow for 2017.

As always, in interpreting our revenue and adjusted EPS guidance ranges, you should focus on the midpoint as the most likely view of how we see results playing out.

So in summary, we've delivered 3 strong quarters of operational performance, flowed through the benefit of a more favorable FX environment and executed really well on our capital deployment strategy.

All of this keeps us well on track to deliver an excellent 2017.

With that, I'll turn the call back over to Ken.

Thank you, Stephen.

Operator, we're ready to open it up for Q&A.

(Operator Instructions) Your first question comes from the line of Derik De Bruin, Bank of America.

So a couple of question.

So the 11% organic number in Analytical Instruments, what was the FEI contribution to that?

Yes.

So Derik, in terms of Analytical Instruments, we had very strong performance from our chromatography and mass spectrometry business.

It's good to see chemical analysis also return to growth.

FEI had a strong double-digit growth in the quarter.

Obviously, it was a partial quarter impact just given the anniversary.

But obviously, electron microscopy also contributed to the strong growth.

Yes.

And so staying on the Analytical Instruments side, and this is a question for both your industrial and your pharma customers, I mean, as we -- as we sort of talk about increasing interest in tax reform in the U.S. and there's talking about immediate [expense-assuming] capital, are you seeing any potential hesitation in terms of people looking to spend in Q4?

The question on the budget fleshing, thinking about if people think tax reform is coming, would they push instrumentation spending off into next year?

Yes.

If I think about what's happened in industrial and applied end markets, we saw real strength in Asia Pacific.

U.S. has been pretty consistent.

Customers really haven't talked much about sitting on the sidelines because of potential tax regulation.

So U.S. has not been strong with industrial.

It's been slowly recovering.

So I don't think we're expecting a big factor one way or the other from sort of U.S. tax policy on demand.

Your next question comes from Tycho Peterson of JPMorgan.

Marc, I want to maybe follow up on that questioning on FEI.

I'm curious to how much of the growth is coming on the semi side versus Cryo-EM uptake.

And then with the new systems, is this reflecting some strong early interest on the pharma side, it seems like the new platforms are geared toward drug development?

Yes.

So Tycho, thanks for the question.

When I think about how the FEI business has performed, given that it's just past the 1-year anniversary, it's a good time to reflect on what's happened.

I think at the highest level, the business has benefited tremendously from our integration approach, right?

Our PPI Business System has helped them expand capacity.

And our business management system, a part of PPI, ruthless prioritization on the most important things has allowed both the material sciences businesses and the Life Sciences businesses to really significantly accelerate growth over anything the business has delivered over the last number of years.

And the team has done a fabulous job of executing.

When I think about the 2 end markets, material sciences is in a strong part of the cycle.

That's both industrial and semiconductor customers.

Semiconductors have been very strong.

But we've also seen a nice acceleration in our Life Sciences customers as well as strong bookings growth as well.

So businesses are performing well across all fronts.

The new products are geared towards both the nano material research on the materials science side.

And on the Life Sciences side, we are getting some level of interest from biotech and pharma customers, although it's still a bit early, but the feedback has been positive.

When you summarize the whole story on FEI, I think the way I would characterize it, performance has been so strong that relative to the underwriting case that we talked about when we announced the deal on the call a little over a year ago, we're going to meet our ROIC hurdle a full year earlier than what we articulated back then.

So it's been a great acquisition (technical difficulty) off to a great start and we're going to fully capitalize on the opportunities ahead.

And then follow-up, just curious on your comments on bioprocess.

There's a fair amount of noise in that market now with biosimilars and some of the drug companies working down inventory.

As both the supplier and the manufacturer, you see both sides.

But just curious, your comments on the outlook for that market.

I know it slowed a little bit last quarter.

That was more timing on the supplier side, but curious as to your outlook there.

Yes.

So Tycho, in terms of bioproduction, we had moderate growth, very similar to what we saw in Q2.

We continue to see very strong (inaudible) indicators that really could show up in the biosciences business for cell culture media and sera as well as in the smaller biotech demand for our clinical trials on activity.

So the early indicators -- leading indicators are very strong.

And conditions were similar to what we saw in Q2 with moderate growth.

And our next question is from Steve Beuchaw of Morgan Stanley.

First question is actually on the fourth quarter, the implied fourth quarter expectations.

It'd be really helpful if you could try to frame up for us, quantify for us, what you think the bottom line impact in the fourth quarter would be from Patheon specifically and from any lingering impacts from the situation in Puerto Rico or the natural disasters, more specifically top, bottom line.

Whatever you have on hand would be very, very helpful.

So I'll do a little bit of it and Stephen will give maybe a more comprehensive view.

In terms of the fourth quarter, we're not -- other than bringing our Manatí, Puerto Rico site back online, we're not expecting really any impact from weather.

So what you would see from that in the fourth quarter is embedded in our guidance.

It's about a $0.05 headwind and probably a little bit we got at the end of the third quarter, but a $0.05 headwind in Manatí based on just getting the operation back online.

And Stephen, you might want to gives us some puts and takes.

Yes.

So just some additional color.

So the $675 million of revenue for Patheon that we've added to guidance, $190 million of that was recognized in Q3.

And then in terms of Q4 for the net accretion, including the impact of the Puerto Rico issue for that site, it's still $0.02 additional accretion in that $0.12 change that I gave you at the midpoint.

Okay.

Got it.

I really appreciate that.

And then Marc, it's always really helpful to hear how you're thinking about a couple of things going forward.

I think one is it's very helpful to hear how you think what the critical sort of factors outside the company's control are with regard to where the trajectory of the business is within the 4 to 6 framework.

And then maybe a subcategory of that framework is always the NIH not necessarily budgets, but more disbursements.

Thanks for the question.

So company is performing extremely well, right?

When I think about the quarter, 5% organic growth.

I think about the end markets, we saw improved performance and really strong execution in both academic and government and industrial, applied, very, very positive.

When I think about the outlook for Q4, basically, we've raised our -- we raised our outlook for organic growth based on the Q3 performance.

We've maintained, for the fourth quarter, the same level of organic growth that we assumed back in July.

And the reason we did that is there's always a range of outcomes on what year-end spend is.

And we'll obviously going to drive to the highest possible number.

So I think in the fourth quarter, the things we look at is where does FX raise finally settling at and, ultimately, what's the level of year-end spend.

And as you look back over many years past, we'll do a good job of capitalizing on all the market opportunities out there and creating some new ones as well.

Your next question is from Doug Schenkel of Cowen.

You increased full year organic growth revenue expectations by $25 million.

This is about the magnitude of the Q3 beat.

It seems like you have stronger-than-expected FEI momentum.

AI grew, I think, around 6% the last 6 months with no signs of slowing momentum.

And Specialty Diagnostics growth is actually improving the levels that we haven't seen in a little while, just to name a few observations.

Your guidance doesn't seem to reflect continuation of improving momentum.

Could you just speak to why that might be?

And then I guess relatedly, is some of this weather?

And would you be willing to quantify specifically what you believe the impact of weather was in the third quarter?

Yes.

So Doug, in terms of the fourth quarter, a couple points.

The first of which is we were very comfortable banking everything we delivered versus our expectations organically in Q3 and then subsequently raising the guidance.

We chose to keep the Q4 number the same as it is because, as you know, it's the one with the widest level of variation based on year-end spend.

And we've assumed year-end spend to be exactly the same level as last year.

So we believe that the range of outcomes has the possibility for better performance.

So I think that's one way to think about it.

I think the other way is just when you go through the numbers, we have a more challenging comparison in our electron microscopy business in the fourth quarter.

So it will be above the company average, and we're very confident of that.

But the contribution might be a little bit smaller in Q4 than what we saw in Q3.

And the weather impact.

Weather here, just in terms of customer demand in Q3, was probably about 0.5 point of impact.

Okay.

And the expectations that some of that lingers into Q4.

Not a material amount.

Okay.

And just one more follow-up.

I know Tycho asked the earlier question on bioproduction.

I apologize if I missed it in his answer.

But when do you expect that to pick up a little bit more -- the bioproduction revenue trend?

And specifically, on destocking, which is what we've heard from a few of your peers, have you seen any impact from destocking in that part of your business?

Yes.

Probably from our company perspective, better to give sort of the pharma and biotech as a end market.

And when I look at that, obviously, solid mid-single-digit growth in the quarter.

Real strength in the research applications.

Bioproduction had moderate growth.

It's a little bit slower, but still a good contributor.

We saw some (technical difficulty) customers managing their inventory really as the -- with the advent of biosimilars becoming more important.

I think customers are just managing inventory in a more prudent fashion.

But the pipeline of new molecules is quite promising, and it will take some time to ramp up.

So we're very, very bullish on the long-term prospects of bioproduction, very bullish on our competitive position across pharma and biotech.

And it continues to be a great end market for us.

Your next question is from Dan Arias of Citigroup.

Maybe just 2 on FEI.

Stephen, on the top line, just curious how much of the organic growth that you're seeing is actually falling through versus being reinvested.

And then along those lines, we're coming into year 1 accretion.

It's more like $0.40 than $0.30.

So is that right?

And just wondering maybe if you have a view on year 2 accretion or synergies just given the way the performance is.

Sorry.

Can you just clarify the first question?

I didn't get it, sorry.

Just sort of trying to understand how much within that business you're actually letting through to the bottom line.

And then on accretion, for the year 1 target that you had $0.30, we're looking at more like $0.40.

Just looking to see if that was right.

Yes.

So we are -- now we're appropriately investing in that business for the long term and you see that -- results of that in the new products that have been introduced this quarter.

But we're also printing very good EPS from the high growth that we're seeing this year.

As you look at the 12-month -- the first 12 months of this acquisition, as you said we outlined $0.30 back at the beginning of the deal.

And we're -- I think the actual number was $0.43, so very strong contribution from the acquisition.

And a significant amount of that was basically the base business revenue being higher.

The synergies are running a little bit ahead, probably $0.01 to about $0.02 of that beat was synergy-related.

The rest was really from the base revenue.

Okay.

And then, Marc had highlighted the new products that you've launched there recently.

So I guess, as we think about the gross margins for the AI business, I'm just curious whether you think that segment can benefit from sort of an improving profile there.

I mean, prior to the deal, those guys had emphasized better gross margins on the newer instruments that were being launched.

So just curious if you think that's something that's meaningful at all going forward.

Yes.

I think you'll continue to see gross margins expand and, certainly, in the electron microscopy business just given the mix over time.

The Life Sciences business, a number of years ago, was a lower-margin business for legacy FEI.

And through our PPI Business System as well as our commitment to innovation, those products are increasing their margins.

The material science applications are still higher margins.

They're kind of a more fully established set of products.

So mix matters within the business.

But in the underlying pieces, margins are expanding in both.

And just one other factor.

The Life Sciences side of the business, the service stream for that is really ramping up.

And that's slightly (inaudible) delays from the ramp-up in the instrument placement.

So that will also help gross margins and -- as we go out next couple of years.

Your next question comes from Jack Meehan of Barclays.

I have 2 biopharma questions.

So wanted to start with Patheon.

So now that you've owned the acquisition for about 2 months, just talk about conviction on the revenue synergy as long-term trajectory there.

And near term, if I think about the implied fourth quarter from Stephen's guidance, I think it's down a little bit year-over-year.

Maybe just how you think that turns going into 2018.

Yes.

In terms of the fourth quarter guidance, we're actually quite bullish on what the outlook is for the business.

The end markets actually look good.

So it is obviously roughly around the 4% range would be is what's implied based on the July guidance.

And as we've talked, there's obviously a range of outcomes with a good year unfinished could drive that higher.

So that's the way to think about it.

But one additional factor is, Jack, is that we have deferred revenue accounting adjustments at the beginning of transactions.

And it's fairly sizable for this deal.

It's about $20 million of impact on revenue and profitability in Q4 for the Patheon transaction.

So we feel good about Q4.

There's -- from that perspective, everything looks strong and solid, so I don't think there's much there.

In terms of going into 2018, looking at the end markets, we'll, obviously, give the more holistic view for the year when we get on to the January call.

But based on what's going on in Washington, we're expecting a budget to get into place for -- with NIH growth towards the end of this year, which would set up as a positive for next year.

Obviously, in industrial and applied, at the beginning of this year, we were talking about a recovery.

And obviously, we're seeing good growth there.

And pharma and biotech has been solid throughout the year.

So at least, as we see the world right now, we're entering 2018 with a lot of really good things going on.

So I feel good about how the team is executing.

Great.

That makes sense.

And then just wanted to nitpick the trends in Lab Products and Services a little bit.

Sequentially, 3% growth, but a little bit softer.

I think you overlap the clinical trial logistics in the fourth quarter.

But maybe just talk about the trends there and what we should think about comp-wise into 4Q.

So sequentially, really, the impact is weather.

It was fairly concentrated in that segment.

It's about a percentage point of growth for that segment.

That's really the sequential change.

So that's -- and then the clinical trial, we will sunset that by the end of Q4.

There's still some run-over revenue that we're lapping in Q4.

We'd fully be done with that by the end of the year.

Your next question is from Patrick Donnelly of Goldman Sachs.

Maybe one for Marc, just on Patheon, I know it's early, but how are things compared to your expectations when it comes to utilization levels at the facilities?

It feels like cost synergies are going to be driven more by improved efficiency there rather than facility consolidation.

So just wanted to hear your kind of general thoughts now that you've had a chance to see them from the inside.

Yes.

Patrick, great question.

So I've had the chance to visit a number of sites and meet with all of the general managers of each of the sites and all the quality leaders.

It's a really strong team.

And there's plenty of capacity to be leveraged, right?

So what's exciting about the Patheon business is that it really is about driving operational efficiency and then leveraging our commercial reach to further fill up the plants.

So incremental volumes really does flow through at an attractive rate.

So driving the top line here is going to be a key driver.

And our PPI Business System is going to help drive further benefits within the plants.

Some of the cost synergies, obviously, is duplicative corporate cost and things of that sort.

So you get those right away and that flows quickly.

And as we continue to drive volume growth, you'll see it flow through at an attractive rate.

So it's early days, but very, very encouraging.

And we're looking forward to really leveraging our commercial infrastructure because the customer feedback has been great about the combination.

So we're very bullish.

It's early, but very bullish at this point.

Okay.

And then on industrial, I know in the past quarters, you kind of talked about core industrial, orders trending up a little bit and U.S. showing signs of life.

And kind of the hope was revenue would follow suit back half.

Could you just talk about kind of an update on the market there and how you feel?

Yes.

So mid-single-digit growth in industrial.

Another quarter of growth in our chemical analysis business.

Really strong Analytical Instruments performance across chrome, mass spec, electron microscopy, environmental instruments, so good demand there.

Asia Pacific was very strong.

U.S. is growing, but it's growing moderately.

So that's obviously still hasn't fully benefited from the recovery.

But we're definitely seeing that real strength in Asia.

So pretty encouraging in terms of where industrial and applied is.

And the applied markets continue to be very, very positive.

And certainly, we saw that in our environmental instruments.

And we just launched a new air monitor.

That makes a difference for that marketplace as well.

So really, a much better part of the cycle than we've been reporting over the last couple of years.

Your next question comes from Paul Knight of Janney Montgomery.

Can you talk about NIH, what you're seeing there?

And then the second question I have is Europe has been better.

Why do you think Europe is better?

Yes.

So Paul, thanks for the question.

So in terms of academic and government, it was really good to see mid-single-digit growth globally.

That's a very strong quarter.

North America was consistent with the last few quarters with modest growth.

And we're expecting NIH budget to show an increase of $1 billion to $2 billion, ultimately, and that should continue momentum into 2018 as well.

So generally, conditions here in the U.S. are stable and growing modestly.

Europe was very good, right?

So we saw that across a variety of our instrument offerings.

In particular, Germany was releasing funds, which was good.

But we saw a broad-based demand from a number of countries.

So I think getting back to a more stable growing European economy, you're seeing governments invest in academic and research.

And that's -- was a real positive in the quarter and it was great translated into -- for the whole -- our whole business, grew mid-single digits in Europe.

So it's very, very encouraging.

And then lastly, FEI, obviously, a good quarter.

What's -- how do you view that business in terms of predictability?

It still has semiconductor exposure.

Is there backlog?

Is there orders?

What -- how -- what's your visibility on FEI going forward?

Yes.

So orders grew strongly in the quarter.

We have a very strong backlog and good visibility for the business.

The Life Sciences business, you can think of it as a rapidly growing business.

And therefore, it's not really subject to sort of the economic cycles as much.

The material science business does have a cyclical nature to it.

It's in a really very positive part of the cycle.

And as we read, certainly, for the next quarter, that's very strong.

The next year's comparison will be more challenging, just given how strong the growth was this year.

But it -- but we're very positive on the outlook for the electron microscopy business.

Your next question is from Steve Willoughby of Cleveland Research.

Most of them have been asked already.

Just one question for you, Marc, on your -- in your AI business on LC and mass spec.

Just wondering if you can provide a little bit more color on what you see going on there as it relates to the strength you're seeing.

Is it your new products?

Is it underlying market growth?

Is it potential share gain in some of those markets?

Just any more color there would be helpful.

When I look at the chrome and mass spec growth that we've delivered for a number of quarters relative to what we can see from the external market, we've been gaining share, meaning, we're growing faster than the others that are reporting the numbers.

And as you recall, when you look at the growth, up until the last quarter or 2, the chemical analysis business, which is not a mass spec business, had been declining.

So when you look at the segment, it looked like a moderate growth, but underlying that was strong mass spectrometry growth.

The reasons for that, I think, are twofold.

One of the things is as you advance technologies, it opens up new desire for the leading researchers to buy the product.

So we continue to innovate.

And therefore, the funding cycle actually follows that innovation.

So as long as the industry is bringing out relevant new products, these best researchers get the money.

So the funding environment has been good.

And ASMS was a great conference for us this year back in June.

And it's rare that I highlight the quarter after product launches, how well received they are, but our 2 triple quads and our new Q Exactive really are off to a fantastic start.

It's a good market and really solid execution for share gain has been what's driving that.

Your next question comes from Catherine Schulte of Baird.

Just thinking into the Analytical Instruments growth a little bit more.

Wondering if you could walk it through by either end market or geography.

Just trying to get a better sense of what was unique in this quarter to get to that 11% number.

I think that the -- probably, it's more the macro of chemical analysis growing versus being a headwind because it had been shirking for several years, right?

It's been a couple of quarters of growth.

So that really makes a big difference.

Even though it's moderate growth, it really does matter because chrome and mass spec has done well.

And then we got some benefit from electron microscopy, which had a very strong quarter.

So that combination really was the big driver.

In terms of geography, the one area I would call out as being just very strong was Asia Pacific, was very good across all segments for our Analytical Instruments markets.

And just as a reminder.

The electron microscopy will -- it's currently showing up in industrial and applied and academic and government and -- where the concentration to revenue is.

Okay.

Great.

That's helpful.

And then just quickly on companion diagnostics.

You have a number of FDA approvals under your belt and now starting to get some reimbursement.

How big of a business do you think that could be in 2018?

Yes.

When I think about the programs in companion diagnostics, we are getting our lab partners up and running on our Oncomine target DX companion diagnostic.

LabCorp (technical difficulty) was up and running more, will get online.

So that business will build throughout the fourth quarter and into 2018.

As you know, the entire next-gen sequencing business is less than 2% of our total revenue, so it's not a huge business.

But certainly, the oncology portion is encouraging in terms of the actions going there.

Your final question comes from Derik De Bruin of Bank of America.

My question's been answered.

Great.

Derik, thanks.

So let me wrap it up.

First of all, when I think about where we are at this point of the year, we're really in a great position to finish the year strongly.

And I look forward to reporting a successful 2017 in January.

Of course, thank you for your support of Thermo Fisher Scientific.

Thanks, everyone.

Have a good day.

This concludes today's conference call.

You may now disconnect.