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Operator
Good morning ladies and gentlemen, and welcome to the Thermo Fisher Scientific 2014 first-quarter earnings conference call.
(Operator Instructions)
I would now like to introduce our moderator for the call, Mr. Kenneth Apicerno, Vice President, Investor Relations.
Mr. Apicerno, you may begin the call.
Kenneth Apicerno - VP of IR
Good morning and thank you for joining us.
On the call with me today is Marc Casper, our President and Chief Executive Officer, and Pete Wilver, Senior Vice President and Chief Financial Officer.
Please note that this call is being webcast live and will be archived on the Investor section of our website, thermofisher.com, under the heading: Webcasts and Presentations until May 16, 2014.
A copy of the press release of our 2014 first-quarter earnings and future expectations is also available on our website under the heading: Financial Results.
So before we begin let me briefly cover our Safe Harbor statement.
Various remarks that we may make about the Company's future expectations, plans and prospects constitute forward-looking statements for purposes of the Safe Harbor provisions under the Private Securities Litigation Reform Act of 1995.
Actual results may differ materially from those indicated by these forward-looking statements as a result of various important factors, including those discussed in the Company's annual report on form 10K for the year ended December 31, 2013 under the caption: risk factors, which is on file with the Securities and Exchange Commission, and also available in the Investor section of our website under the heading: SEC filings.
While we may elect to update forward-looking statements at some point, in the future we specifically disclaim any obligation to do so, even if our estimates change.
Therefore you should not rely on these forward-looking statements as representing our views as of any date subsequent to today.
Also during the call we'll be referring to certain financial measures not prepared in accordance with generally-accepted accounting principles, or GAAP.
Our reconciliation of these non-GAAP financial measures to the most directly comparable GAAP measures is available in the press release of our first-quarter 2014 earnings and future expectations, and also in the Investor section of our website under the heading: Financial Information.
So, before we get started, one other item to note is that the commentary we provide on today's call regarding the Company's revenue growth by end market and geography is on an organic basis only, and therefore does not include the performance of Life Technologies.
So with that, I'll now turn the call over to Marc.
Marc Casper - President & CEO
Thank you Ken, and good morning everyone.
Thank you for joining us today our Q1 call.
I am pleased to report that we achieved a number of significant milestones in the first three months of the year, and our performance positions us well to meet our goals for 2014.
First, as you all know we closed on our acquisition of Life Technologies in early February.
I spent quite a bit of time since then traveling to our new sites in the US and Europe to do business reviews, hold town halls, with our new colleagues and visit with our customers.
I continue to be impressed by the caliber of people I meet, the innovative technologies being developed, and the passion the team has for using science to make a real difference in the world.
It's also very clear to me that the Life Science Solutions team shares our commitment to unrivaled industry leadership, and that's an important common denominator.
On the topic of integration, I'm very pleased to report that our teams are implementing their plans and executing extremely well.
We had a number of months to plan for the integration so the teams were able to hit the ground running immediately after the close.
As you know we have a great track record of integrating acquisitions and achieving the synergies that we sign up for.
We've targeted $85 million of synergies in 2014 from the Life Technologies transaction and have no doubt that we'll accomplish that goal.
In late March we completed the sale of the related divestitures that we previously announced to GE, and we received over $1 billion for our cell culture sera and media, gene modulation and magnetic beads businesses.
We were pleased to be able to complete the transaction expeditiously.
The proceeds provide us with more cash to pay down our debt and we still expect to achieve our target leverage during the third quarter of 2015 as we said on our Q4 call.
Last, but very important, our teams remain intensely focused on our customers and executed very well to deliver solid financial results in Q1.
We leveraged our top-line growth and focused on controlling costs to once again continue our long trend of delivering outstanding adjusted EPS performance.
I'll now cover the financial highlights, give some commentary on our end markets, hit some of the business achievements, and end with our guidance.
As you saw in our press release, our results in Q1 include Life Technologies since early February, and exclude the divestitures as of late March.
That said, our total revenue for the quarter grew 22% year-over-year, adjusted operating income was $830 million in the quarter, and we expanded our adjusted operating margin by 200 basis points to 21.3%.
The addition of Life Technologies businesses and our solid operational execution resulted in adjusted EPS performance of $1.53 per share.
This was a 12% increase over 2013 and sets us up to deliver another year of consistently strong adjusted EPS growth.
As you know we used our PPI business system to continuously drive margin expansion and significant productivity across our global operations.
In a market where we're still seeing some unit growth in certain customer segments, this is a key competitive advantage.
One quick anecdote on this topic: our Laboratory Equipment Center of Excellence in Asheville, North Carolina was recently recognized as one of the best plants in the US by Industry Week magazine.
I visited the plant in March to congratulate the team for the great work they've done to achieve this distinction.
This was actually the second time one of our factories has won this award.
Both plants had aggressively implemented the PPI business system across their operations, and both were great examples of the impact that PPI can have.
Our PPI business system is already being implemented at our new sites within Life Science Solutions, and we are beginning to see the resultsm which we'll highlight for you at our analyst meeting next month.
Now let me give you my perspective on our performance in the context of our four key end markets.
I'll start by saying that in aggregate, our outlook for the year hasn't changed.
So beginning with academic and government, this end market started off in Q1 a little softer than what we had experienced over the past year or so, most likely due to some of our US customers working fewer days.
Overall, we said last quarter that these customers would probably begin spending money under the new appropriations at around midyear.
Our view on that hasn't changed, and we believe this end market will improve in the second half as funds begin to flow.
Turning to diagnostics and healthcare, our performance here was relatively flat overall, reflecting the lower healthcare utilization in the US that's been widely publicized.
On the other hand, we had very good growth in our transplant diagnostics and immunodiagnostics businesses.
As the year plays out and utilization increases, we expect growth for the full year to be in line with the Company average.
In industrial and applied, we delivered mid-single-digit growth as conditions here continued to improve.
You may recall that last quarter we said we believed the industrial market had begun to stabilize.
To provide you a little more color from a product perspective, we're pleased with our ongoing strength in chromatography and we saw a nice pickup during the quarter in our portable analyzer business.
Last, in pharma and biotech, we delivered high-single-digit growth in the quarter, driven by continued strength in our clinical trials logistics and mass spectrometry businesses.
It's clear that our biopharma customers continue to recognize the benefits of our unique value proposition.
So in summary, as I mentioned at the beginning of my commentary, in aggregate, our outlook for the full year is consistent with our original guidance.
Let me shift now to talk about the great progress we're making in strengthening our Company to gain market share.
As you know, we have a solid strategy for increasing share gain with our customers to drive growth.
It 's based on three core elements: technology innovation, our unique customer value proposition, and our scale in Asia-Pacific and emerging markets.
We've followed this playbook for a number of years, it's served us well, and the acquisition of Life Technologies further enhances all three elements of our strategy.
My point today is that we'll continue to execute the strategy to best serve our customers and strengthen our position as the unrivaled industry leader.
In that context let me cover some of the business highlights from the quarter.
First, we kicked off the year with a lot of new products that strengthened our position as the innovation leader in our industry.
Starting with Pittcon, the leading analytical instruments show, our theme this year was around helping customers run their laboratory operations more efficiently, regardless of the industry they're in.
Our new Thermo Scientific products included instrument software, data management systems, and new additions to our molecular spectroscopy and lab products offerings.
To highlight two of the new launches, we released another update of our Gold-Standard Chromatography Data System Chromeleon 7.2.
This new version allows customers to control their mass spec instruments on a single data platform with gas, ion, and liquid chromatography instruments.
We have good momentum in our chromatography and mass spec businesses, and this industry-leading software package is another step in further strengthening our competitive position.
I also want to mention a small but innovative new product, the Virtuoso System for vial identification.
This system prints barcodes directly on even the smallest vials to provide a data trail that could prevent the loss of valuable samples.
This is a growing problem, and you may have seen the news last week about thousands of vials containing the SARS virus that were lost in a prestigious European research lab.
At Analytica, we launched a number of new Thermo Scientific products that can help our laboratory and biotech customers improve productivity.
Highlights included a new cell culture surface that better models cancer cell growth to accelerate research.
We also introduced a new system for protecting individual samples during long-term storage.
Separately we launched the Life Technologies Quantifiler Trio and HP kits for more accurate forensic analysis of highly compromised samples.
Q1 also marked the launch of Ion Chef, which is used to automatically prepare DNA samples before they're loaded into the Ion Torrent gene sequencer.
The key advantages of this new product are that it saves time for researchers and also reduces variability during the process to improve results.
We shipped a significant number of our units to our customer base in the quarter and early feedback is very positive.
Let me now turn to our customer value proposition and give you an example from the quarter that shows how our increased depth of capabilities is a real differentiator for Thermo Fisher.
We highlighted our expanded offering in bioproduction and bioprocessing at a leading biopharma manufacturing tradeshow called Interfax.
For the first time our Thermo Scientific and Life Technologies offerings were displayed side-by-side in the booth.
We launched several new single-use technologies at the show to strengthen our leading position in this product offering.
Customers could also see the added capabilities we now have in upstream cell culture applications, downstream purification, as well as analytics for detecting and quantifying impurities.
This combination gives us a strong position in serving biopharma customers who are focused on bringing new biologics and vaccines to the market more quickly and cost-effectively.
I'll make a couple quick comments on Asia-Pacific and emerging markets before wrapping up with our guidance.
Let me start with China, where we recorded low double-digit growth during the quarter.
We continue to have excellent momentum in serving health care, although this is still a relatively small segment in China today.
Our performance here was led by strong demand for a range of products in our specialty diagnostics businesses.
As you know, we continue to increase our presence across the high-growth regions.
We delivered good growth in India, driven by strong sales of our analytical instruments and the addition of Life Technologies builds on our leading presence across Asia-Pacific.
In Southeast Asia for example, we plan to further leverage the manufacturing infrastructure that we now have in Singapore.
I am traveling to Asia shortly, and I look forward to visiting several of our sites and spending time with some of our key customers there.
So I think this gives you a good sense of all the opportunities we have to drive growth and the great progress we're making in the three elements of our strategy.
Turning now to our annual guidance.
As you saw in our press release, we're raising both our revenue and adjusted EPS guidance for the year.
The increase primarily reflects the timing of the Life Technologies acquisition and related divestitures.
They also reflect a slight improvement in foreign exchange rates versus our assumption at the beginning of the year.
Pete will cover the details of our guidance in his remarks, but at a high level, we're raising our revenue guidance for 2014 to a new range of $16.84 billion to $17.0 billion for 29% to 30% revenue growth year-over-year.
We're also raising our adjusted EPS guidance to a new range of $6.80 to $6.95, which would result in 25% to 28% adjusted EPS growth over our strong performance in 2013.
Before I turn the call over to Pete, let me leave you with a few takeaways.
First, we closed our acquisition of Life Technologies to further strengthen our strategic position.
We had a very active quarter in terms of technology innovation with many new product launches, and we continue to build on our scale to take advantage of the growth opportunities in Asia-Pacific and emerging markets.
We are clearly the unrivaled leader in our industry and that puts us in an excellent position to continue to gain share.
With that, now to you, Pete.
Pete Wilver - SVP & CFO
Thanks Mark.
Good morning, everyone.
I'll begin with an overview of our Q1 financial performance for the total company, then provide some color on each of our four segments, and conclude with our updated 2014 guidance.
Before I get into the details of our results, as we stated in our press release, our financial results for the quarter include Life Technologies as of February 4, and exclude the related divestitures as of March 22.
As I mentioned last quarter, at the total Company level, we're reporting organic revenue growth using our standard methodology.
That means we'll exclude the results of Life Technologies until we reach the one-year anniversary date of the acquisition.
However, for the Life Sciences Solutions segment, which consists primarily of the Life Technologies businesses and our remaining biosciences businesses, we're providing organic revenue growth on a pro forma basis, as if we had owned Life Technologies for all of 2013 and 2014.
We're doing this to give you insight into the growth performance of that segment.
So starting with our overall financial performance, we delivered a solid quarter resulting in a 12% increase in adjusted EPS to $1.53.
GAAP EPS was $1.36 in Q1, up 46% from $0.93 in Q1 2013, primarily as a result of the gain on the divestitures.
Starting with the top-line, Q1 total revenue increased 22% year-over-year and we delivered 2% organic growth.
Q1 reported revenue includes 20% growth from acquisitions net of divestitures, and an immaterial positive impact from foreign exchange.
We strengthen our backlog in the quarter with bookings exceeding revenue by 2%.
By geography, North America declined organically in the low single-digits, Europe grew in the mid single-digits, and Asia-Pacific grew in the high single-digits, with China growing low double-digits.
Rest-of-the-world grew in the low single-digits.
Looking at our operational performance, Q1 adjusted operating income increased 35% and adjusted operating margin was 21.3%, up 200 basis points from Q1 last year.
Our adjusted operating margin expansion for the quarter was driven primarily by the addition of Life Technologies, which had a higher overall margin rate compared to stand-alone Thermo Fisher.
However, we also continued to see contribution from our primary productivity levers: global sourcing, site consolidations, and our PPI business system.
In total, operating performance for standalone Thermo Fisher contributed about 30 basis points to adjusted operating margin expansion in the quarter.
We realized benefits from our restructuring actions of $13 million in Q1, and are on track to achieve about $45 million of benefit for the full year.
We also realized synergy benefits of $17 million in Q1, in line with our guidance of $85 million for full-year 2014.
In terms of supporting our growth initiatives, we continue to make strategic investments primarily to strengthen our presence in emerging markets and continue our growth momentum in those regions.
Moving on to the details of the P&L, total company adjusted gross margin came in at 48.2% in Q1, up 420 basis points from the prior year.
This was primarily due to the acquisition, along with solid productivity.
Adjusted SG&A in Q1 was 23.1% of revenue, 140 basis points unfavorable to the 2013 quarter, again primarily as a result of the acquisition, partially offset by volume leverage and our productivity actions.
Finally, R&D expense came in at 3.8% of revenue for the quarter, 70 basis points above the prior year.
This reflects the relatively higher level of investment in R&D in the Life Sciences Solutions segment.
R&D as a percentage of manufacturing revenue in Q1 was 6%.
Looking at our results below the line, net interest expense in Q1 was $106 million, up $49 million from last year driven primarily by the debt we raised to fund the Life Technologies acquisition.
Adjusted other income for Q1 was $3 million, about the same level as Q1 last year.
Our adjusted tax rate in the quarter was 16.0%, 430 basis points above last year.
This was primarily as a result of higher-than-average credits in the prior year related to foreign tax credits and the double R&D tax credit, which has not yet been approved for this year.
Although this quarter's rate is slightly above our full-year tax rate guidance of 14.5% to 15.5%, this was assumed in our previous guidance, as we only included a partial quarter of benefit from the acquisition tax synergies in Q1.
So we're maintaining our full-year adjusted tax rate guidance, and we expect that our adjusted tax rate will be below the Q1 rate for the balance of the year.
In terms of returning capital, we paid out $55 million in dividends to our shareholders the quarter.
Average diluted shares were 398.4 million in Q1, up 36.7 million or 10% from last year, primarily as a result of the shares we issued to partially fund the Life Technologies acquisition, and to a much lesser degree, option dilution.
Turning to cash flow and the balance sheet, there are a lot of moving pieces, primarily related to the acquisition and related divestitures.
The headline numbers for Q1 are $102 million of cash flow from continuing operations, and free cash flow of only $1 million after deducting $101 million of net capital expenditures.
This compares to $236 million of free cash flow in the prior year.
In the quarter, we incurred $240 million of one-time payments related to the acquisition close that were netted against operating cash flow, including financing fees, transaction fees, and restructuring costs.
In our acquisition model, these outflows were primarily included as up-front deal costs.
Cash flow from working capital in the quarter was reduced by about $50 million as a result of the close timing and related opening balance sheet amounts, and our tax payments were $115 million higher than the prior year, primarily because of the quarterly phasing of last year's payments.
This will even out through the rest of the year.
So as I said, a lot of moving pieces this quarter.
We ended the quarter with $1.52 billion in cash and investments, down $4.3 billion sequentially from Q4 as a result of funding the Life Technologies acquisition.
Our total debt at the end of Q1 was $17.4 billion, up $6.9 billion from Q4 as a result of drawing down our $5 billion term loan and issuing $0.5 billion of commercial paper to fund the acquisition, as well as assuming $2.3 billion of Life Technologies debt.
Our cash balance at the end of the quarter was about $1 billion higher than we need to maintain on an ongoing basis because the divestiture proceeds were received very late in Q1.
These proceeds were used to pay down debt early in Q2.
Let me wrap up my comments on the total Company with a quick update on our performance in terms of return on invested capital.
Our trailing 12-months adjusted ROIC in the first quarter of 2014 was 9.5%, down 60 basis points from Q4 as a result of the Life Technologies acquisition.
As we normally do, we'll give you a longer-term view of ROIC at our analyst meeting on May 20.
So with that, now I'll walk you through the performance of our four business segments.
Starting with the new Life Sciences Solutions segment, in Q1, total revenue significantly to $836 million from $173 million in the prior year, primarily as a result of the Life Technologies acquisition net of divestitures.
On a pro forma basis, assuming Life Technologies was owned for the entire quarter in both the current and prior years, organic revenue grew 1%.
In the quarter we saw good growth in our bioprocess production business and in next-gen sequencing, partially offset a tough comparison in licensing revenues.
Q1 adjusted operating income for Life Sciences Solutions also increased significantly, primarily as a result of the acquisition, with adjusted operating margin up 550 basis points to 29.3%.
Because of the timing of the acquisition close, Life Sciences Solutions Q1 reported results include only February and March, which historically have higher-margin than January as a result of the phasing of revenue versus expenses throughout the quarter.
As a result, we expect adjusted operating margin in the segment to be about 250 to 300 basis points lower in Q2 compared to Q1, but this should increase throughout the year as revenue and synergies increase.
In the analytical instrument segment, in Q1 total revenue and organic revenue both grew 4%.
In the quarter we had very strong growth in our Life Sciences mass spec and chromatography businesses, which benefited from good performance in Europe and Asia-Pac.
Q1 adjusted operating income in analytical instruments increased 9% and adjusted operating margin was 17%, up 70 basis points.
The margin expansion was driven by strong pull-through on top-line growth and good contribution from productivity actions, partially offset by strategic growth investments and unfavorable foreign exchange.
Turning to the specialty diagnostics segment, in Q1 total revenue grew 1% and organic growth was modestly positive.
In the quarter, we continue to deliver good growth in our transplant diagnostics business, and our immunodiagnostics business grew in the mid single-digits.
As Marc noted earlier, we believe this was more than offset by weak healthcare utilization in the US.
Adjusted operating income in the segment declined 1% in Q1 and adjusted operating margin was 27.2%, down 50 basis points from the prior-year.
In the segment, we delivered good productivity.
This was more than offset by strategic growth investments and some unfavorable mix.
In the laboratory products and services segment, both reported revenue and organic revenue grew 2% in Q1.
Our clinical trials logistics business continued to deliver very strong growth, but softness in the US academic and in government end-market, as Marc mentioned, continued to be a headwind in this segment.
Adjusted operating income in laboratory products and services grew 1% for the quarter, and adjusted operating margin was 14.7%, down 10 basis points as good productivity was more than offset by strategic growth investments and unfavorable foreign exchange.
So with that, I'd like to review the details of our full-year 2014 guidance.
As you saw in our press release, on the top-line, we're raising both the low and high end of our reported revenue range, primarily as a result of the acquisition and divestiture timing, as well as more favorable foreign exchange.
This leads to a new full-year 2014 revenue guidance range of $16.84 billion to $17.00 billion, which represents growth of 29% to 30% compared to our reported revenue of $13.1 billion in 2013.
To bridge the $190 million revenue increase from the midpoint of our previous guidance, we picked up $120 million related to the acquisition, primarily as a result of an earlier close date than our previous assumption, $45 million as a result of more favorable FX rates on Thermo Fisher standalone, and $25 million as a result of the divestitures closing later than our previous assumption.
On an organic basis, we're still guiding to stand-alone organic growth for full-year 2014 up 3% to 4% consistent with our previous guidance.
As I mentioned earlier, this measure of organic growth does not include the results of Life Technologies.
For the Life Sciences Solutions segment, we still expect 2% to 3% pro forma organic growth for full-year 2014, also consistent with our previous guidance.
In terms of FX, assuming recent rates, the year-over-year foreign currency impact on our revenue will now be slightly positive.
However, we're still expecting a slightly unfavorable margin impact resulting from the mixed currencies, with the stronger euro and British Pound offsetting the weaker Japanese yen, which pulls through at a much higher rate.
The Life Technologies acquisition net of related divestitures is expected to contribute about 26 percentage points to our total revenue growth in 2014.
And consistent with past practice, we haven't attempted to forecast future foreign currency exchange rates, and our guidance does not include any future acquisitions or divestitures.
Moving to adjusted EPS, we're also raising both the low and high end of the range in line with the change in our revenue guidance.
This results in new full-year 2014 adjusted EPS guidance range of $6.80 to $6.95, which represents growth of 25% to 28% over our 2013 adjusted EPS of $5.42.
To bridge the roughly $0.08 increase in adjusted EPS from the midpoint of our previous guidance, we added about $0.10 from the acquisition net of divestitures, and about $0.02 from more favorable FX, which was partially offset by increased investments and some segment mix.
Turning to adjusted operating margin, we are maintaining our previous guidance for the full year of 220 to 250 basis points of expansion.
We continue to expect solid contribution from our productivity actions at about $85 million of synergy benefit in 2014 from the Life Technologies acquisition.
Moving below the line, we're expecting net interest expense to be in the range of $430 million to $440 million, up $10 million from our previous guidance.
This is driven by the timing of the acquisition and divestiture close dates.
Q2 interest expense will increase by about $10 million from Q1, as a result of having a full quarter of outstanding debt, and then will decrease throughout the year as we use our cash flow to pay down debt.
As I mentioned earlier, we're still forecasting our adjusted income tax rate to be in the range of 14.5% to 15.5%, consistent with our previous guidance, and we're still assuming that we'll return approximately $240 million of capital to shareholders, all in the form of dividends and that in addition to the proceeds of the divestitures, we'll use the bulk of our free cash flow to pay down short-term debt.
Full-year average diluted shares are estimated to be in the range of 402 million to 405 million, up 10% to 11% from 2013.
Similar to interest expense, our share count will increase by about 4 million shares in Q2 compared to Q1, as a result of having the acquisition-related shares outstanding for the full quarter.
We're still expecting net capital expenditures to be in the range of $470 million to $490 million, and in terms of free cash flow nothing has changed in our assumptions as to our year-end cash balance for the speed at which we expect to pay down our outstanding debt.
However, solely as a result of the reporting of acquisition and divestiture-related cash flows, we now expect reported full-year free cash flow to be about $2.2 billion, which is below our previous guidance of $2.55 billion to $2.65 billion.
One final note on guidance: we don't normally provide detail other than annual guidance, but similar to last quarter, there are a lot of moving parts related to the acquisition and divestitures in our Q1 results, so I thought it would be helpful to give you some insight into what we're expecting for Q2.
In terms of revenue, we're expecting Q2 to represent about 25% of our full-year revenue guidance, and in terms of adjusted EPS, we're expecting Q2 as a percentage of our full-year guidance to represent a couple points less than the comparable revenue percentage, as a result of the acquisition synergies and revenue building throughout the year.
As always, in interpreting our full-year revenue and EPS guidance ranges, you should focus on the midpoint as our most likely view of how we see the year playing out.
Results above or below the midpoint will depend on the relative strength of our markets during the year.
In summary, we completed a number of significant milestones this quarter while delivering solid operational results, which positions us well to achieve our financial goals for the year.
With that I'll turn the call back over to Ken.
Kenneth Apicerno - VP of IR
Thanks Pete.
Stephanie, we're ready to open it up for Q&A.
Operator
(Operator Instructions)
Jon Groberg, Macquarie.
Jon Groberg - Analyst
I guess the first question, Marc, for you, is North America now is going to be a slightly larger part of your revenue's given life and obviously still a little bit weaker.
Can you maybe, you talked about government and academic health care utilization, but could you maybe give us a little bit more detail, kind of, by segment what you're seeing in North America and how you see that playing out throughout the rest of the year?
Marc Casper - President & CEO
Sure.
In terms of North America, Jon, in aggregate things were fairly similar to what we've seen over the last year or two, with two exceptions: healthcare utilization is typically at your peak in Q4, and at your trough, or lowest level of utilization, in Q1.
So that's a pattern a started in 2013 and continues to be even a little bit more dramatic as you get to 2014.
So you have that dynamic and we expect that that improves as the year unfolds.
From an academic and government perspective, the appropriations is a positive, and as we said on our original call in February, we expect funds to flow from the appropriations to happen in the second half of the year, which is kind of customary in terms of how that works.
Clearly, as we have talked to a number of customers, they work fewer days in the early part of the year, and that had some effect on our industry in terms of consumable demand and that should obviously be just a one-time factor that will not repeat as the year goes on.
Jon Groberg - Analyst
And some of the -- what were kind of some of the applied markets or some of the more industrial markets in those markets in North America?
Marc Casper - President & CEO
From a North American perspective nothing really changes, industrial or applied continues to strengthen and pharma and biotech continues to be an area of strength for the Company, so those are clearly positives.
Jon Groberg - Analyst
If I could just, quickly, on, you mentioned Interfax [and I've stood over there] and then looking at the opportunities with your bag business and Gibco and just, obviously, the more you dig into this it looks like there's a lot of opportunity from a revenue synergy standpoint.
I know it's not something you've talked about as much in the investment community because it's harder to get credit for, but maybe now you have met with people, Marc, you're traveling around, as you said, you're examining opportunities that are going to be going over to Asia.
I'm just curious, from a revenue synergy opportunity, how are you thinking about the acquisition with Life relative to maybe, where you were six months or so ago?
Marc Casper - President & CEO
From our perspective, we are very excited about the logic of the combination and the revenue synergies that we're going to capture over time.
In fact that will be one of the themes that we cover at our analyst day; Mark Stevens will walk through some of the things that we're working towards.
Not going to have a big impact in 2014.
We've assumed that there won't be any revenue synergies this year, although I assume we'll deliver something in the later half that's small.
But they really ramp up in 2015 and beyond.
In the area of the one that you actually saw yourself, in Interfax, we didn't assume a lot of revenue synergies because we were doing a divestiture and so forth, but it's a great combination of having the single-use technologies from our Thermo Scientific brand being combined with the Life Technologies position in the media, sera as well as the downstream analytics.
So that combination should actually be quite powerful, and over time, should put us in a position to gain significant share in that market segment.
Other areas of revenue synergy, clearly our e-commerce capabilities are strengthened by the combination, great strength in Asia-Pacific and emerging markets, and good opportunities to leverage our complimentary channel strength, both our Fisher Scientific channel, as well as the strength that Life Technologies brings to the Company.
So lots of opportunities for the Company to capture revenue synergies.
Operator
Ross Muken, ISI Group.
Ross Muken - Analyst
So I guess on, the core growth number for the quarter, how did it sort of pace relative to your expectations as, sort of, the quarter went on and relative to, sort of, your view coming in?
And how do we put in context the Book to Bill, which is not a metric we look at for you guys that often, as it's usually around 1, but it was sort of, particularly robust this quarter.
How do we put all that in context?
Marc Casper - President & CEO
When we looked at our original growth outlook for the year in our guidance call at the beginning of the year, we looked at 3% to 4% organic growth for Thermo Fisher, and 2% to 3% for the Life Sciences Solutions segment.
The Q1 performance, nothing has changed in terms of our expectation for the full year; we're very confident in our ability to achieve both of those milestones.
When I look at the first quarter and the question around phasing, January and February were softer than normal, March was a strengthening and obviously bookings also were much better than revenue and that's really driven by just the timing as customers got back to work later in the quarter.
We had good bookings momentum, which gives us confidence as we continue through the year to achieve our organic growth goals.
Ross Muken - Analyst
I guess just relative to growth in China, we had run at 20% for a long time; it came down to mid-, upper-teens and now we're kind of in the low-double-digits.
As you think about that geography going forward, obviously the PMIs haven't been great, it seems like the health care piece is quite healthy, the industrial is a lot more mixed.
Any sort of pacing there or change there in terms of how you're thinking about that as a growth contributor maybe on the near- versus longer-term basis?
Marc Casper - President & CEO
I'm actually heading off to China next week.
My view is a couple things.
One, we continue to have a very strong position, we deliver good growth, albeit a little bit slower than we ever delivered over the past couple of years.
Healthcare is very strong and that's been a continuing trend, and I agree, industrial is a bit mixed.
We spent time with the team, we'll spend more time with the team, basically nothing has changed with the long-term outlook in terms of our view on China.
We still believe it's going to be in the range of mid-teens as the year progresses.
Ross Muken - Analyst
And just one quick one for Pete, did you call out, maybe I missed it, the actual dollar contribution in the quarter from last?
I know you give us a net number.
Are you going to be providing that so we can kind of back in?
Pete Wilver - SVP & CFO
What I said is the operative performance of Thermo Fisher standalone was about 30 basis points of margin expansion in the quarter.
So that's really the number to look at.
The rest came from --
Ross Muken - Analyst
I'm sorry, on a revenue basis, revenue dollar.
Pete Wilver - SVP & CFO
Off the top of my head I don't know the number.
I believe it's in my script.
Operator
Tycho Peterson, JPMorgan
Tycho Peterson - Analyst
Marc, first question just on the Pharma channel, it's obviously a been a busy week in M&A world for Pharma and health care in general.
Can you maybe just talk about your view on the trajectory?
I know you previously guided for deceleration in the Pharma business but what's your kind of latest thinking as we think about all the potential M&A here?
Marc Casper - President & CEO
The first thing is another very strong quarter performance in our biopharma customer set.
A little bit stronger than the full-year guidance that we gave in February so team executed well.
Obviously a lot of corporate repositioning announced over the last 24 to 48 hours with our customer set.
I think as companies look for synergies, we typically gain share.
They have targets, we have incredibly strong relationships with the executive team, and we bring them ideas on how they can get higher impact for their dollars to spend.
In fact two of the CEOs that were involved in those repositionings, and I already communicated about some opportunities.
We have very strong real-time relationships with these customers.
Tycho Peterson - Analyst
And then as we think about the integration initiatives, I mean obviously you've highlighted PPI for your own business, can you just talk, maybe, about how easy it is to port over that process to the Life business and other, kind of, big next steps?
I guess you'll get into a lot of this at the analyst meeting but how do we think about applying PPI to the underlying Life business?
Marc Casper - President & CEO
Even though we've only owned the business for a couple of months, the reality is they're already starting to use our business processes in terms of how we operate our business.
And we already have our PPI methodology being implemented and we'll highlight some of the impacts of that.
But that's something that we start right at the beginning, and start with the training, start with the impact, and it's part of the synergies that we deliver and it's part of the ongoing productivity that we'll be able to drive for that business and certainly improve our customer experience, which positions us to accelerate growth and gain share.
Tycho Peterson - Analyst
Last one, Pete, can you quantify the weather impact?
It's a tricky thing, I'm sure, but I'm just wondering if you've got a number you can throw out?
Pete Wilver - SVP & CFO
Yes, it's obviously not an exact science but when we look at the weather impact as well as the impact of seasonal products, both flu and pollen were down versus the prior year.
It's about a one-percentage point impact on the quarter.
Operator
Derik De Bruin, Bank of America Merrill Lynch.
Derik De Bruin - Analyst
Pete, just a question, I'm getting some questions from people on the second quarter guidance that you're basing the trajectory there, I assume the midpoint of that's a little bit lower than the street number for the EPS number if you sort of use your math.
I assume that's just on, all relative to the timing of synergies and when things are coming through.
Could you talk about your plans in terms of how you're looking at synergies and what the different phases are with that?
Pete Wilver - SVP & CFO
Yes, so just one thing to keep in mind in terms of Q2, we always have a seasonal impact in Q2 because that's when we do salary increases so that has an impact on the bottom line.
And that's true for Life technologies as well, so that could be one of the differences.
In terms of the synergies, we obviously realize $17 million in Q1 already.
Those were the duplicative public company costs that we're able to eliminate pretty much on day one.
And then as we go through the year, we're continuing to eliminate duplicative corporate costs, corporate functions, and we're beginning to integrate the biosciences business, the businesses of legacy Thermo Fisher that were combined into Life technologies to create Life Sciences Solutions, so those will build throughout the year.
Derik De Bruin - Analyst
Marc, has there been anything that's stuck out in Life in terms of what you've got under the hood and looked for potential, I would say, revenue surprises in the sense of more opportunity to develop new products, more potential downstream synergies in terms of revenues, potential for the Company, new product investments?
I'm just getting curious in terms thinking how you're thinking about the business now that you've got your hands on it.
Marc Casper - President & CEO
So as we started the last couple months, part of the activity is for myself and other members of the team, just to get visibility to our new colleagues, visit customers jointly, and really look at the opportunities.
One of the things that, to me, has been a real highlight is I spent quite a bit of time meeting with some of our new scientists that aren't new to the Company but are new to Thermo Fisher, and they're working on great technologies.
So we're bringing a really, a complimentary suite of technologies.
And we're already brainstorming long-term on what are the new solutions that we can bring out from combining the two companies' suites of technology capabilities.
So long-term, I am very excited about what both companies bring.
From a customer perspective, feedback is incredibly positive.
They see great synergy between the Company and that positions us in the opportunity to gain share.
So no surprises but it's been very positive and the business is performing as we expected so we're off to a good start.
Operator
Doug Schenkel, Cowen and Company.
Unidentified Participant - Analyst
This is actually Crispin on for Doug today.
Thanks for taking my question.
I guess just to start, is there anything you can share regarding the changes in allocation of investment of Life Technologies's product pipeline or commercial infrastructure that you have implemented or are implementing since the deal closed?
Marc Casper - President & CEO
From my perspective, what we do from an innovation perspective is make sure that we're maximizing the impact of our investment.
Innovation is a core part of our strategy.
It's part of the reason that we're meeting with our scientific leaders and scientists just to really get an understanding of what is in the pipeline.
It's business as usual right now, which is, team's working on great things and they're doing a good job and that's what they're focused on.
And certainly we're looking for what are the new opportunities that the combined company has going as we get later into the year and into 2015?
So it's a very exciting time from a scientific and innovation perspective.
Unidentified Participant - Analyst
Also a bit more specific question, but I think it's a sort of interesting and relevant product line question: with One Lambda and Life under Thermo, can you just talk about the development efforts of sequence-based HLA typing?
This is a rapidly growing market and one of your biggest competitors announced earlier this year that it would be making a push into this market.
So how are you thinking about the competitive dynamics and the sequencing market size?
HLA sequencing, sorry.
Marc Casper - President & CEO
In terms of our transplant diagnostics business, it's doing really well.
It's been a great acquisition, it's growing well above what the acquisition [model] was doing in 2012 so I feel great about that.
We have integrated the HLA capabilities from a sequencing perspective that Life Technologies brought to Thermo Fisher into that business already.
So that's a combined offering that we're working on and we feel good about our prospects in that area.
Operator
Steve Willoughby, Cleveland Research.
Steve Willoughby - Analyst
I was wondering if you could provide a little bit more color as it relates to the growth rates within the Life Sciences Solutions segment.
Specifically, if you strip out the standalone or existing Thermo business, what did that grow versus what did the Life Technologies business grow?
And then my second thing was just on the analytical instruments business.
I heard you said that mass spec and chromatography both saw strong growth; was wondering if you could just talk about the remaining piece of that business and what the trends are with those products.
Marc Casper - President & CEO
In terms, Steve, of the analytical instruments business, what else is in there is a lot of our industrial chemical analysis businesses.
So great strength in chrome and mass spec, you still have some weakness in the later-cycle, longer-lead time products.
So that would be what you see there.
Although I was encouraged in the quarter by the strengthening in our portable instruments business, that's kind of the shorter-cycle industrial business.
So that saw a nice pick-up in the quarter, so there's some signs of a continued economic recovery in the industrial markets.
From the Life Sciences Solutions perspective, we're already integrating our business so we're thinking about that as one unified business as we put our biosciences business in there.
The growth rates were pretty similar between what would have been legacy Thermo Fisher products and what was the Life Technologies products.
They both grew around the same rate in aggregate.
That is the view on the splits there, Steve.
Operator
Tim Evans, Wells Fargo Securities.
Tim Evans - Analyst
Just a follow-up there on the commentary, on the question from Steve.
In the Life Sciences Solutions business, could you maybe give us a little bit more commentary around the clinical end markets that that business serves, particularly in molecular diagnostics products or the products going into that market?
Marc Casper - President & CEO
Yes, so Tim, let me give maybe a little bit more color in aggregate on the Life Sciences Solutions segment just to frame it, and I'll cover clinical as well in that.
So when I look at the performance of the business and the outlook, first of all, we feel confident about the 2% to 3% growth organically this year.
Within Life Sciences Solutions you really have three main businesses: Bioproduction, which is our fastest-growing portion of the portfolio; you have Biosciences, which is our market leading position in our high-tech bioscience reagents; and you have Genetic Sciences, which is made up of our qPCR franchise; our applied markets such as human identification; you have animal and food testing as well; you have our next-gen sequencing business as well as our Sanger Sequencing franchise.
Within the next-gen sequencing and Sanger Sequencing businesses, you actually have a nice clinical presence as well.
There's adoption of both of those technologies there.
And we continue to have good momentum in that part of our portfolio.
In terms of highlights, as I thought about it, for the quarter, what I would say is I was very encouraged to see that qPCR had a good quarter in terms of growth, we have really nice momentum in next-gen sequencing, so I think that that's really a nice compliment to how the Life Sciences Solutions team has started off the year.
Tim Evans - Analyst
So given those dynamics, though, in the 1% growth, the headwind from the licensing maybe some other pieces of the business must have been fairly significant.
Marc Casper - President & CEO
Yes, so headwinds.
The OEM licensing royalties were all headwinds, versus what was a strong Q1 of 2013.
We saw some headwinds in portions of our Sanger Sequencing business as well.
So those would be the headwinds that we would've seen in Q1.
Operator
Isaac Ro, Goldman Sachs.
Isaac Ro - Analyst
Pete, just wondering if you could put a little color on the pricing environment this quarter, and your expectations for the year in the context of your core growth guidance.
Pete Wilver - SVP & CFO
Sure; in the quarter we did realize positive price but it was between 0 and 50 basis points, so pretty much consistent with what we've seen for the last, really, every quarter in the prior year, so slightly positive.
That's basically what we're assuming for the full year, around 25 basis points.
Isaac Ro - Analyst
And then, Marc, just a follow-up to the earlier question on Pharma, the M&A activity there.
If we were to compare the share gains that you typically get in the sense of opportunities against the overarching cuts that you typically see in the combined R&D budgets for those accounts, is it fair to say the net effect of those two forces is typically a positive for your business in those accounts?
Marc Casper - President & CEO
Yes.
As we have said in years past, typically you get a little bit of a dampener as companies are figuring out exactly what they're going to be doing.
But we typically then gain share because we're part of their synergy program and they typically move spend to us as part of that process, and that's out to be, over time, a positive for Thermo Fisher.
Operator
Paul Knight, Janney Capital Markets.
Paul Knight - Analyst
Marc, you had mentioned the handheld market in that kind of a leading indicator for these applied markets improving.
Have you been surprised how slow it's taken the industrial market to improve?
Marc Casper - President & CEO
I'm not surprised, Paul.
We're in this new normal of more slow recovery, economically, globally.
So we're seeing the improvements now, in our shorter-cycle business, and that's good news, and then that should lead to stabilization in the longer lead time businesses.
So we didn't come out of the last recession with a big spring-back in terms of growth, but it's something that we assumed and we're managing through, which is why the use of PPI and really managing our costs effectively position the Company so well.
We've been able to deliver great earnings growth in a muted top-line environment, and we feel like we're very well positioned to capitalize on the opportunities that are out there.
Paul Knight - Analyst
And specifically, the Niton analyzer, probably, in the metals mining market, you're seeing, I guess, stability there?
Marc Casper - President & CEO
Yes, we're seeing growth again in our handhelds, which is a good leading indicator for us.
Paul Knight - Analyst
And then you've cited mass spectrometry.
I think that must be stable pharma and biotechnology capital going into that market?
Marc Casper - President & CEO
Those two are good drivers, plus really great products.
Our products are just being adopted.
So from our perspective, we have a really exciting pipeline of demand for what we launched at ASMS last year and we're looking forward to ASMS coming up later in the spring and the new suite of products as well.
So it's a combination of good biotech --
Operator
Jeff Elliott, Robert W. Baird.
Jeff Elliott - Analyst
Just a follow-on to Paul's question.
Can you give a little more color on where you're seeing the growth in MS and in chromatography, and perhaps an update on the competitive environment?
Marc Casper - President & CEO
Sure.
The Orbitrap Fusion Tribrid is doing great.
High-end research, academic, biopharma, extreme strong adoption.
So that's been a very positive driver.
From a chromatography perspective, applied markets, industrial markets, have been good for chromatography.
We have strength in liquid chromatography, we had strengthen ion chromatography in the quarter, and feel like we're well-positioned there.
So those are two businesses that have very good growth in the quarter.
Jeff Elliott - Analyst
Just a follow-up on China, can you give a little more color on some of the growth that you're seeing in other areas there, like some of the more applied areas, environmental and whatnot?
Marc Casper - President & CEO
Yes, so I would say industrial and applied -- not dramatic changes from what we've seen over the last few quarters, we saw a little bit of a slowness in the release of funds from government customers in China.
That happens from time to time.
That seemed to be a factor that played out a little bit in the quarter.
Operator
Brandon Couillard, Jefferies.
Brandon Couillard - Analyst
Pete, on the free cash flow revision, could you elaborate on the moving parts that are contemplated in the new outlook relative to the prior view?
Pete Wilver - SVP & CFO
Sure.
So as I said, nothing has really changed in the operational side of our free cash flow guidance, but as I said there's lots of moving pieces just in the way that acquisitions and divestitures our reported.
As I said in Q1, we had about $240 million of payments related to the acquisition that hit free cash flow, $50 million of working capital impact.
Then just to give another example that we'll experience later in the year, the gross proceeds of the divestitures are excluded from free cash flow, but in fact the tax payments that we'll make are actually included in free cash flow.
So in that case nothing's changed in our assumption that we're going to get somewhere around $800 million net from the divestitures, but reported cash flow take a hit of over $200 million as a result of that.
So the change is in the range of $400 million, again, nothing operational, doesn't change our year-end cash balance forecast or how fast we think we're going to pay down debt.
It's just, simply, the moving pieces of how the acquisition and divestitures are reported.
Brandon Couillard - Analyst
Marc, you spoke to the government academic markets in the US, but curious what your view would be for that end market in the European and Asian geographies.
Marc Casper - President & CEO
Generally Europe, in its entirety, continues to be consistent.
We have mid-single-digit growth in the quarter continuing to benefit from stability, and that's been a positive.
There's been some exciting R&D initiatives, so the government-funded bode well for a long-term European demand, so I feel good about that.
We had -- I don't think we mentioned as much, but we had good position and good strength in Japan in the quarter.
There are some initiatives around a tax increase that went into effect April 1 that encouraged customers to spend some money, so that's off to a good start as well.
That's a quick view on academic and government around the world.
Let me wrap it up with just a couple of quick comments.
As I think back on the quarter we made significant progress in Q1, I think we delivered solid results and positioned ourselves well to deliver another strong year.
Thanks for the support of Thermo Fisher Scientific and certainly we look forward to updating you next quarter.
Thanks, everyone.
Operator
Ladies and gentleman, that does conclude today's conference.
You may all disconnect, and everyone have a great day.