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Operator
Good afternoon, everyone. My name is Kevin, and I'll be your conference operator today. At this time, I'd like to welcome everyone to the Paysign, Inc. First Quarter 2023 Earnings Conference Call. (Operator Instructions) As a reminder, this conference call is being recorded.
The comments on today's call regarding Paysign's financial results will be on a non-GAAP basis unless otherwise noted. Paysign's earnings release was disseminated to the SEC earlier today and can be found on the Investor Relations section of our website, paysign.com, which includes reconciliations of non-GAAP measures to GAAP reported amounts.
Additionally as set forth in more detail in our earnings release, I'd like to remind everyone that today's call will include forward-looking statements regarding Paysign's future performance. Actual performance could differ materially from these forward-looking statements. Information about the factors that could affect future performance is summarized in the end of Paysign's earnings release and in our recent SEC filings.
Lastly, a replay of this call will be available until August 10, 2023. Please see Paysign's earnings release for details on how to access the replay.
It's now my pleasure to turn the call over to Mr. Mark Newcomer, CEO. Please go ahead.
Mark R. Newcomer - Co-Founder, Chairman & CEO
Thank you, Kevin. Good afternoon, everyone, and thank you for joining our first quarter 2023 earnings call. I'm Mark Newcomer, Chief Executive Officer, and I'm pleased to share our results with you today. We have seen solid growth in this quarter, and I will be discussing our high-level results and providing updates on our plasma and patient affordability verticals, then handing it over to our CFO, Jeff Baker, for further details.
The first quarter is typically our weakest quarter of the year as plasma donors receive their tax refunds. I am pleased to report that our Q1 revenue reached $10.1 million, representing a 23% increase compared to Q1 2022. Our load volumes increased 17%, and our spend volumes increased 31% compared to the first quarter of last year. During the quarter, we expanded our center account to 439. We added 10 new centers from existing clients, saw 11 centers close for nonperformance and 4 centers sold to a nonclient.
Our negotiations with 1 of the 4 largest plasma collection companies are ongoing following our RFP win. We have also executed contracts with 2 new entrants in the plasma space with expected center launches in Q3 2023. The global plasma fractionation market as estimated by Growth Plus Reports was worth $29.83 billion in 2022. The market revenue is projected to grow at a CAGR of 6.9% from 2023 to 2031, reaching $54.37 billion. The United States continues to be the leading provider of plasma, supplying 2/3 of the world's demand with an annual growth rate of 6% to 8%. We maintain our forecast for 45 to 55 new center openings and expect strong year-over-year growth in plasma from both existing and new clients.
Moving on to our Patient Affordability business. In 2021, we saw continued growth in this vertical with 7 new programs launching. Over the last 2 quarters, we have experienced a consistent increase in new program acquisition and claim volume, and we expect to maintain this positive momentum throughout the year.
Three of the programs that launched in the first quarter were from a top 25 pharmaceutical manufacturer. This unique program offers free goods to specific patient populations, covering more than 10 brands and supports a portfolio of free drug programs.
Our success in winning new business is directly related to our innovative products addressing critical industry issues, such as copay accumulators and maximizers. We are expanding the therapeutic classes addressed by our services, which is crucial for winning new business and larger programs this year.
The selling cycle for small-to-midsized programs remains close to 90 days, indicating strong reception of our products in the marketplace. We recently participated in the annual Asembia Summit in Las Vegas, where we held over 45 in-person meetings with potential clients. Our team secured meetings with 10 of the top 20 pharmaceutical manufacturers in the United States. We believe our innovative solutions, subject matter expertise and superior service are attracting decision-makers controlling broad portfolios of pharmaceuticals.
We are making headway in winning portfolio contracts, which would significantly increase our top line revenue, claim volume and market position. Our agility, dedicated teams and focused product offerings allow us to outperform larger competitors with decades of experience. Our clients consistently provide positive feedback on the quality of our services and our ongoing innovation. Many of the programs we are launching are transition programs where we are replacing existing competitors. This success demonstrates our ability to begin dominating the market. I am confident in our Patient Affordability team's ability to continue adding long-lasting and diversified revenue streams.
Jeff, over to you.
Jeffery B. Baker - CFO & Treasurer
Thank you, Mark. Good afternoon, everyone. As Mark pointed out, we are beginning to build real momentum with our Patient Affordability business, while our plasma business continues to show steady and improved growth. For those unfamiliar with our Patient Affordability business, this is the same as our pharma co-pay business, which is reported in our financials under our pharma line of business.
The momentum in our Patient Affordability business can be confirmed by looking at the 7 new programs we added during the quarter, bringing our total number of active programs to 26. Patient Affordability revenues more than doubled to $590,000 versus $261,000 during the same period last year. Our plasma business continued its growth exiting the quarter with 439 centers versus 375 centers during the same period last year. Our average revenue per plasma center per month also grew to $7,066 versus $6,672, a year-over-year increase of 5.9%.
We are encouraged by this growth as the first quarter has typically been our weakest quarter of the year, thus, we believe we have established a good baseline for the rest of the year. As in previous calls, with all the details we provided in the press release and that will be available in our 2Q (sic) [10-Q] tomorrow morning, I will simply hit the financial highlights for the first quarter of 2023.
First quarter 2023 total revenues of $10.1 million increased $1.9 million or 23%. Of that amount, plasma revenues increased 27% to $9.4 million, pharma revenues declined 27% to $590,000, and other revenue increased 883% to $194,000. It is important to note that all of the pharma revenues reported this quarter and all quarters going forward are made up 100% of our Patient Affordability or pharma co-pay business. Thus, there was no pharma prepaid revenue this quarter, but there was $545,000 of pharma prepaid revenue during the same period last year.
As previously disclosed, all pharma prepaid business ceased in November of 2022. Gross profit margin for the quarter was 49.8% versus 60.8% during the same period last year. There are a number of moving pieces to explain the decline, including the lack of revenue from our highest-margin pharma prepaid business, a onetime timing benefit of commission obligations due that were related to a contract renewal last year, price increases by our service providers implemented in the second half of last year and internal inflationary wage pressures related to our customer service representatives.
SG&A for the quarter increased 6.6% to $4.9 million, with total operating expense increasing 8.8% to $5.8 million. In addition to inflationary wage pressures across the company, we made significant investments over the past year to support the continued growth in our business, exiting this year with 112 employees versus 80 employees during the same period last year.
For the quarter, we posted a net loss of $160,000 or just under breakeven per diluted share versus a net loss of $309,000 or a net loss of $0.01 per share. The first quarter adjusted EBITDA, which adds back stock compensation to EBITDA was $720,000 or $0.01 per diluted share versus $927,000 or $0.02 for the same period last year.
Regarding the health of our company, we exited the quarter with $6.4 million in unrestricted cash and 0 debt, which is a decrease of $3.3 million from our December 2022 ending cash balance. $666,000 of the cash usage was related to our share repurchase. We expect the first quarter to be a high watermark for cash usage after adjusting for working capital needs related to our pharma co-pay business.
Now turning your attention to our guidance in the press release. We are not changing our guidance for full year 2023 that has been previously provided. For the second quarter of 2023, we expect total revenue to increase 15% to 20% and adjusted EBITDA to increase 5% to 10% from the second quarter of 2022. Again, we are excited about the traction and growth we are experiencing in our Patient Affordability business and our ongoing growth in our plasma business. The success in both of these businesses is being driven by our innovative solutions, subject matter expertise and superior service.
With that, I would like to turn the call back over to Kevin for question and answers.
Operator
(Operator Instructions) Our first question today is coming from Jon Hickman from Ladenburg.
Jon Robert Hickman - MD of Equity Research & Special Situations Analyst
Can you refresh my memory the difference in gross margins between your plasma and your pharma business like just on average?
Jeffery B. Baker - CFO & Treasurer
Yes, Jon, the plasma business gross margin is going to be around the upper 40s, low 50s depending on volumes and then pharma co-pay is going to be around the 80 -- upper 70%, 80% range.
Jon Robert Hickman - MD of Equity Research & Special Situations Analyst
Okay. So I heard what you said about your competitive advantages in the pharma business, your Patient Affordability. Is there one of those things that -- I mean has something happened in the industry or anything like that to kind of help you to jump-start this business?
Matthew Turner - VP & Head of Patient Affordability Solutions
Jon, Matt Turner here. So I think a big thing we've been focusing on is solutions that are related to combating co-pay accumulator and maximizer programs. And we started working on those solutions last year. And now we're really seeing those take hold, and we're able to get additional programs from larger clients kind of coming out of last year and into the first quarter of this year and then moving forward to this year.
Jon Robert Hickman - MD of Equity Research & Special Situations Analyst
So you said you added 7 new programs this quarter?
Matthew Turner - VP & Head of Patient Affordability Solutions
That's correct. Yes. That's correct.
Jon Robert Hickman - MD of Equity Research & Special Situations Analyst
Can you give us any idea of the pipeline? Like has it become a dozen or...?
Matthew Turner - VP & Head of Patient Affordability Solutions
Yes. I mean I don't think I can give a number right here. But I think we're -- we feel very strongly of the pipeline. We've got a variety of different size manufacturers and different size programs in the pipeline for this year. We've got programs we're bringing up this quarter, and we do have programs scheduled to launch throughout the remainder of the year.
Jeffery B. Baker - CFO & Treasurer
And Jon, in last call, we gave -- we did give a little insight into that where we either were live with customers, which would include the 7 that went in the first quarter or we're in contract or we had verbal for a total of 19, that pretty much took us through the end of September. Most of the programs that are onboarded are done earlier in the year versus late in the year. So we feel pretty -- like I said, we launched 7 and the pipeline back then was 19.
Operator
We reached the end of our question-and-answer session. I'll turn the floor back over for any further or closing comments.
Mark R. Newcomer - Co-Founder, Chairman & CEO
Thanks very much for joining, everyone. We look forward to speaking to you next quarter. You all have a good upcoming weekend.
Operator
Thank you. That does conclude today's teleconference and webcast. You may disconnect your line at this time, and have a wonderful day. We thank you for your participation today.