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Operator
Good day, ladies and gentlemen, and welcome to the Medpace First Quarter 2021 Earnings Conference Call. (Operator Instructions) As a reminder, this call may be recorded.
I would now like to introduce your host for today's conference call, Kevin Brady, Medpace's Executive Director of Finance. You may begin.
Kevin M. Brady - Executive Director of Finance
Good morning, and thank you for joining Medpace's First Quarter 2021 Earnings Conference Call. Also on the call today is our President and CEO, August Troendle, and our CFO and COO of Laboratory Operations, Jesse Geiger.
Before we begin, I would like to remind you that our remarks and responses to your questions during this teleconference may include forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. These statements involve inherent assumptions with known and unknown risks and uncertainties as well as other important factors that could cause actual results to differ materially from our current expectations.
These factors, including the ongoing impact of COVID-19 on our business, are discussed in our Form 10-K and other filings with the SEC. Please note that we assume no obligation to update forward-looking statements even if estimates change. Accordingly, you should not rely on any of today's forward-looking statements as representing our views as of any date after today.
During this call, we will also be referring to certain non-GAAP financial measures. These non-GAAP measures are not superior to or a replacement for the comparable GAAP measures, but we believe these measures help investors gain a more complete understanding of results. A reconciliation of such non-GAAP financial measures to the most directly comparable GAAP measures is available in the earnings press release and earnings call presentation slides provided in connection with today's call. The slides are available in our Investor Relations section of our website at investor.medpace.com.
With that, I would now like to turn the call over to Jesse Geiger to discuss our financial results and guidance.
Jesse J. Geiger - CFO & COO of Laboratory Operations
Thank you, Kevin, and good morning, everyone.
Net new business awards entering backlog in the first quarter increased 44.2% from the prior year to $356.2 million, resulting in a 1.37 net book-to-bill. Ending backlog as of March 31 was $1.6 billion, an increase of 26.1% from the prior year. Revenue was $260 million in the first quarter of 2021, which represents a year-over-year increase of 12.6% on a reported basis and 11.6% on a constant currency organic basis.
EBITDA of $53.6 million increased 32.1% compared to $40.6 million in the first quarter of 2020. On a constant currency basis, first quarter EBITDA increased 34.1% compared to the prior year. EBITDA margin for the first quarter was 20.6% compared to 17.6% in the prior year period. The higher margin was primarily attributable to lower reimbursed out-of-pocket expenses as a percentage of revenue.
In the first quarter of 2021, net income was $43.3 million compared to net income of $29 million in the prior year period. Net income growth was primarily driven by higher EBITDA as well as a lower effective tax rate. Net income per diluted share for the quarter was $1.14 compared to $0.76 in the prior year period.
Regarding customer concentration, our top 5 and top 10 customers represent roughly 16% and 24%, respectively, of our first quarter revenue.
In the first quarter, we generated $57.3 million in cash flow from operating activities. And our net days sales outstanding decreased compared to the fourth quarter, from negative 33.6 days to negative 40.8 days. We ended the first quarter with $332.9 million of cash, no outstanding debt and $50 million of undrawn capacity on our revolving line of credit.
Moving now to our guidance for 2021. We are now forecasting total revenue in the range of $1.09 billion to $1.15 billion for the full year 2021, representing growth of 17.7% to 24.2% over 2020 total revenue of $925.9 million. This reflects our current view of a slightly slower return of reimbursed out-of-pocket costs and the associated revenue related to investigator site payments.
Our 2021 EBITDA is expected in the range of $205 million to $215 million, representing growth of 9.2% to 14.5% compared to EBITDA of $187.8 million in 2020. This updated EBITDA guidance reflects increased cost expectations related to our strong hiring in the first quarter and anticipated continued robust headcount growth.
We anticipate our 2021 effective tax rate to be in the range of 12% to 13%. We have assumed 37.9 million fully diluted shares for 2021, and there are no share repurchases in our guidance. We forecast 2021 net income in the range of $160.6 million to $167.6 million and earnings per diluted share in the range of $4.24 to $4.42, with the increased expectations for net income and earnings per diluted share driven by the anticipated lower tax rate.
With that, I will turn the call back over to the operator so we can take your questions. Operator?
Operator
(Operator Instructions) Your first question comes from the line of Sandy Draper with Truist Securities.
Alexander Yearley Draper - MD of Equity Research
And just wanted, the first question, Jesse, I think I heard you right, but to confirm. It sounds like the trimming off of the top end of guidance is pretty much solely due to lower pass-through revenue. You're not looking at a lower expectation for service revenue. Is that correct?
Jesse J. Geiger - CFO & COO of Laboratory Operations
That's the largest driver, Sandy, yes. We're just seeing a slightly slower return of the burn rate. And it's particularly influenced by the pass-through cost, in particular site payment activity. That's right.
Alexander Yearley Draper - MD of Equity Research
Okay. So is that somewhat -- go ahead, August. Sorry.
August James Troendle - Chairman, President & CEO
I just want you to understand, obviously, that reflects a little bit slowdown in our expected overall activity at sites. That does slow things overall a bit. But it is disproportionately pass-throughs, but it also slows service revenue to an extent.
Alexander Yearley Draper - MD of Equity Research
Got it. But it's not indicative that you're seeing a slowdown of RFPs or proposals or broad demand. It's just more of a near-term dynamic related to getting sites back and running and that we're still sort of obviously coming out of the back end, but still in a pandemic.
August James Troendle - Chairman, President & CEO
Correct.
Jesse J. Geiger - CFO & COO of Laboratory Operations
That's right. Yes. We're still seeing a good business environment. We're still seeing good RFP flow, good funding dynamics in biotech. Those fundamentals are still intact.
Alexander Yearley Draper - MD of Equity Research
Okay. Great. And then my follow-up or unrelated follow-up, I know I ask about this a lot. But just in terms of the hiring, obviously, you said you did a good job hiring. You've got aggressive plans. Is it still the same strategy? Have you changed anything to try to accelerate that? But it looks like the success is happening, but just thoughts on your go-to-market strategy for hiring people, is it still pretty much the same approach?
August James Troendle - Chairman, President & CEO
That's correct. I don't think we've got any real change in hiring. We will be hiring throughout the year, we think.
Operator
Your next question comes from the line of John Kreger with William Blair.
John Charles Kreger - Partner & Co-Group Head of Healthcare Technology and Services
Just a follow-up on that. If you think about your revenue guidance for the full year, what sort of hiring or staff increase would you expect by year-end?
August James Troendle - Chairman, President & CEO
We don't really try to project that out, but I think we're going to continue to hire relatively rapidly through the year. I don't think it will match the first quarter's hiring rate, but we'll continue to hire pretty strongly.
John Charles Kreger - Partner & Co-Group Head of Healthcare Technology and Services
Okay. So sort of catching up to revenue growth but maybe not quite getting there?
August James Troendle - Chairman, President & CEO
That's possible.
John Charles Kreger - Partner & Co-Group Head of Healthcare Technology and Services
Okay. And then, August, maybe just to follow up on your comments to Sandy's question. Can you just talk a little bit more about what caused the backlog conversion to revenue in the first quarter to come down a little bit? I know there's just general variability in that metric, but would you expect it to trend back up as we move through the rest of the year?
August James Troendle - Chairman, President & CEO
Yes. I don't think it's going to go down. And then it's hard to predict. And you're right, there's a lot of volatility there. But I think fundamentally, there has been a greater delay related to COVID. And we have had a couple of studies that were held up in first quarter for other reasons, for actually drug availability reasons.
But the biggest thing, I think, is just a little bit of headwind from COVID activity at sites, et cetera. That is a little bit more than we had anticipated at this point. We kind of hoped that things were going to lift and things were really going to run quickly. We're still hoping that as you get later in the year, this is going to be the dynamic. But things have moved a little bit. There hasn't been much change at sites over the last several months.
John Charles Kreger - Partner & Co-Group Head of Healthcare Technology and Services
And maybe just one more follow-up on that. Is that comment sort of a global one or are you seeing a disparity in site accessibility in the U.S. versus Europe versus Asia?
August James Troendle - Chairman, President & CEO
I mean, certainly, they differ by region, but it is generally pretty broad statement that we've seen a little bit more slowing than we'd anticipated.
Operator
Your next question comes from the line of Dave Windley with Jefferies.
David Howard Windley - MD & Equity Analyst
I wanted to try to clarify a little bit on the margin first. So I understand your comments about predominantly pass-through impact on revenue, which, I mean, I understand it's not a big change, but would have at least a slight impact, positive impact on mix toward margin driving revenue. But your margin for the balance of the year is down on the hiring. Can you just help to understand a little bit more the magnitude of the moving parts there?
August James Troendle - Chairman, President & CEO
We're hiring. And a lot of that didn't hit first quarter, but they were hired late in the first quarter. And we're continuing to hire, and so I think it kind of layers in as you go through the year. But Jesse, do you want to address?
Jesse J. Geiger - CFO & COO of Laboratory Operations
Yes. You're right on. The driver on margin is really the elevated hiring. We had a strong hiring in Q1. As August mentioned, it didn't necessarily happen literally or sequentially ratably across the quarter. But then we are continuing aggressive hiring as we move through these next couple of quarters based on the view of strong demand in the market. And it's personnel-related costs driving the margins. We make investments.
David Howard Windley - MD & Equity Analyst
Got it. And on that relative to burn rate and maybe, August, your answer to John or Sandy's question might have been thinking service revenue. But the revenue guidance does seem to suggest that at least at the midpoint your burn rate maybe ticks down ever so slightly for the balance of the year, but let's say it basically doesn't change. Can you help me understand, it sounds like you're aggressively accelerating hiring or at least in the first quarter, it was pretty rapid, but you're not really expecting, say, a return to higher conversion out of backlog. And so again, just trying to understand the hiring need versus the pace at which you expect revenue to come out.
August James Troendle - Chairman, President & CEO
Yes, sure, Dave. We hire towards the longer-term needs. And the business environment is very strong. Our backlog is growing. It's, what, 26% year-over-year. That conversion rate will come back and things will unwind. We'll get a substantial surge in revenue growth.
So we do hire ahead of the curve. I think our utilization rate is running in the low to mid-70s, which is a good place for us. But we do think given the environment, and it will continue for a while and in fact we've got a lot of kind of pent-up backlog that will eventually convert at a more normalized rate, we're going to need the staff. So we like to get well out in front of that, but we don't really look at it in terms of, well, we're not going to have the activity this next quarter so let's not hire. I think we have the luxury of being able to look out quite a ways and we're not trying to defend a particular margin.
David Howard Windley - MD & Equity Analyst
Got it. And then maybe last question, your backlog coverage metric improved very nicely. Certainly was above where we were looking for. Kind of the coverage ratio, as a result of that, ticks up a few percentage points. Should we interpret that as cover may be impacted by fourth quarter, first quarter, kind of the outer quarters of that time frame? Or maybe another way to ask the question is, is the cadence of revenue through the year fairly gradual or are you seeing because of the impact of what you're describing, pass-through payments, is that more of an immediate impact in 2Q and then a steeper inflection after that? Just trying to get a sense of cadence.
August James Troendle - Chairman, President & CEO
Yes. Jesse, you want to?
Jesse J. Geiger - CFO & COO of Laboratory Operations
Yes, Dave. From a cadence standpoint, we still do expect revenue to be slightly back-end weighted kind of second half versus first half as we think about the movement of it through the year.
Operator
Your next question comes from the line of Erin Wright with Credit Suisse.
Erin Elizabeth Wilson Wright - Director & Senior Equity Research Analyst
Great. There's obviously a lot of commotion in the CRO space right now, several pending strategic reviews and transactions. I assume you don't see a need for a competitive response given your unique focus. But have you already been seeing some benefit potentially from disruption in terms of win rates or customer dynamics or hearing anything from your customers or the number of résumés that you're seeing? I'm curious if you're seeing anything on that front.
August James Troendle - Chairman, President & CEO
Yes. Sure, Erin. I don't think we've seen anything. I think, yes, we have not heard of any kind of disruptions or work being brought our way because of concerns or anything like that. The environment is strong for us anyway.
And in terms of activity on the recruitment, we have kind of geared up our recruitment. And we did hire pretty strongly in the first quarter. And we got some individuals that came from competing companies, but I can't say that it was any relation to any of the pending deals.
Erin Elizabeth Wilson Wright - Director & Senior Equity Research Analyst
Okay. All right. And then can you speak a little bit to the nature of the new business wins in the first quarter, looking at the therapeutic mix or customer mix? Was there anything that was disproportionately, like outsized larger contracts that were influencing the new business wins? I'm curious if there is anything to call out on that front.
August James Troendle - Chairman, President & CEO
No, I don't think there's anything unusual in terms of size or therapeutic area. Oncology kind of led in terms of our awards. So I don't really see any kind of unusual nature to it.
Operator
(Operator Instructions) Your next question comes from the line of Donald Hooker with KeyBanc.
Donald Houghton Hooker - VP & Equity Research Analyst
Maybe some more granular questions. I'm not sure if I missed this, but the tax rate for this year looks pretty favorable. Can you walk through some of the moving parts there? It looks like you're benefiting from a particularly low tax rate. What would you recommend we expect beyond the current year kind of on a more normalized basis?
August James Troendle - Chairman, President & CEO
Jesse?
Jesse J. Geiger - CFO & COO of Laboratory Operations
Yes. Thanks, Don. Yes, the Q1 rate is highly influenced by our deduction for employee stock option exercises. These are discrete items that we take the deduction in the quarter of the exercise. And these are options largely issued at the time of the IPO that vested in the latter part of last year. And so we do anticipate some of that to continue. That's why we've lowered our tax rate guidance from 15% to 16% down to the 12% to 13% range.
Longer term, I would say our current longer-term tax rate assumption right now is around 20%. That's based on current laws. And that does not impact any early analysis of any of the proposed changes in tax law that are being considered.
Donald Houghton Hooker - VP & Equity Research Analyst
Okay, super. And maybe last, another one for me. In terms of, obviously, another very topical area is the use of virtual clinical trials, decentralized clinical trials, telehealth and those concepts. I would love your kind of maybe broader perspective. This is a question we could probably be asking you every quarter in terms of any changes you're seeing there in terms of acceptance and use of some of these virtual technologies with respect to your business and the industry.
August James Troendle - Chairman, President & CEO
Jesse, you want to?
Jesse J. Geiger - CFO & COO of Laboratory Operations
Yes, Don. Nothing that we've really changed or that we're seeing changing kind of from last quarter. I think we're operating well in a hybrid decentralized environment. We have the tools we need. We're always investing in technology enhancements for different things like remote data capture, remote data review, platforms for wearable technologies. Those are the themes of kind of where we're making some investments, but that's all kind of factored into our ongoing costs. Nothing that we see there that's any sort of major investment. But no, we're active, and I think the environment is going to continue to be one that is operating in some sort of hybrid style versus what it had been pre-pandemic.
Operator
(Operator Instructions) I am showing no further question at this time. I would now like to turn the conference back to Kevin Brady.
Kevin M. Brady - Executive Director of Finance
Thank you for joining us on today's call and for your continued interest in Medpace. We look forward to speaking with you again on our second quarter 2021 earnings call. Thanks and have a good day.
Operator
Ladies and gentlemen, this concludes today's conference. Thank you for your participation and have a wonderful day. You may all disconnect.