Voyager Therapeutics Inc (VYGR) 2016 Q4 法說會逐字稿

Good day, ladies and gentlemen. Welcome to Voyager Therapeutics' fourth quarter 2016 and yearend investor update call. (Operator Instructions) As a reminder, today's conference call is being recorded.

I would now like to introduce your first speaker for today, Matt Osborne, Head of Investor Relations and Corporate Communications. You have the floor, sir.

Thank you, operator. Good morning. Welcome to the Voyager Therapeutics fourth quarter and full year 2016 financial and operating results conference call. This morning we issued a press release which outlines these results. The release is available at voyagertherapeutics.com.

Today, on our call, Dr. Steve Paul, Voyager's President and CEO, will discuss the corporate highlights and goals. Dr. Bernard Ravina, Voyager's Chief Medical Officer, will review the clinical program highlights. Jane Henderson, Voyager's CFO, will review the fourth quarter and full year financials, and provide 2017 financial guidance. And then we will open up the call for your questions.

Before we begin, just a reminder that the estimates and other forward-looking statements included in this call represent the company's view as of today, March 15, 2017. Voyager disclaims any obligation to update these statements to reflect future events or circumstances. Please refer to today's earnings release as well as Voyager's filings with the SEC for information concerning risk factors that could cause actual results to differ materially from those expressed or implied by such statements.

With that, I'll pass the call over to Steve.

Thank you, Matt, and good morning, everyone. 2016 was a very strong operational year for the company as we progressed our lead program for advanced Parkinson's disease further into the clinic and our additional preclinical program towards lead candidate selection. These efforts culminated last year when we reported positive interim results from our Phase 1b trial of VY-AADC01 in advanced Parkinson's disease and more recently when we announced lead candidate selection for our ALS program targeting the SOD1 mutation.

During 2016, through careful capital allocation, we continue to invest in our baculovirus/Sf9 cell production, and manufacturing process and capabilities to ensure both high quality and yield, and that our product engine runs at full potential. These investments in our pipeline programs, vector engineering and manufacturing, form the foundation for what should be exciting years ahead.

Indeed, our systematic approach to progressing our Parkinson's disease program in our ongoing Phase 1b trial has been rewarding for us and inspiring to investigators. Looking back nearly one year ago we had presented efficacy data from really only a single patient treated at one center with only one dose and at only three months of follow-up.

Fast forward to today, and we have successfully treated 15 patients, provided positive interim results from 10 patients at six months of follow-up and from eight patients at 12 months of follow-up, treated at two clinical trial sites and at three-dose levels varying both the volume and concentration of vector delivery. And the interim data we provided served as proof of concept that a one-time targeted delivery of a gene therapy was well tolerated and could enhance patients' responses to levodopa, while at the same time producing durable dose-related and clinically meaningful improvements in motor function in these very advanced patients.

We are encouraged by the safety profile of VY-AADC01 observed so far, and are pleased at the effect of this one-time treatment with no indwelling hardware or invasive device is large and consistent with the range of what has been seen in deep brain stimulation trials in patients with similar characteristics. We believe this could offer a compelling alternative for the thousands of advanced Parkinson's disease patients who already elect to undergo deep brain stimulation each year, and based on the mechanism of VY-AADC01 could be synergistic with novel, non-oral forms of levodopa currently in development. And we are excited that the data from our trial has been accepted as a late-breaking oral presentation at the upcoming American Academy of Neurology meeting taking place in Boston next month as Bernard will discuss.

So we are purposefully taking a very thoughtful approach in developing VY-AADC01 and would be remiss if we did not fully explore the therapeutic dose range before moving into a larger confirmatory registration type study as Bernard will discuss. We are in the final stages of optimizing both the dose and delivery of VY-AADC01.

As exciting as the progress is with our Parkinson's disease program, we are equally committed to and enthusiastic about the progress of our other pipeline programs. We continue to advance our ALS program targeting the SOD1 mutation as well as our Huntington's, Friedreich's ataxia, vectored anti-tau antibody, and NaV1.7 pain programs.

We were very pleased that at the beginning of this year, we selected a lead clinical candidate, VY-SOD101, for this monogenic form of ALS. We selected our clinical candidate after screening a series of AAV capsids, microRNA expression cassettes, and vector genomes through multiple rounds of optimization that resulted in a clinical candidate that is both very potent and highly selective for silencing SOD1. In addition, many of our candidate vectors were evaluated for those that would provide excellent yields in genome integrity for a scale-up in our baculovirus/Sf9 cell manufacturing process.

Preclinical data in large mammals, including non-human primates, demonstrated that a single intrathecal administration resulted in robust knockdown of SOD1 in motor neurons. Based on these results, the VY-SOD101 clinical candidate was selected. We are now conducting the necessary preclinical pharmacology and toxicology studies to support filing an IND application during the fourth quarter.

The entire team at Voyager contributed to the progress of our lead and pipeline programs. But it is worth highlighting the efforts of Dinah Sah and Bernard Ravina, who we proudly promoted to chief scientific officer and chief medical officer respectively earlier this year. Their experience, leadership, and collaborative spirit are exemplary. And I am thrilled to be able to work alongside them.

I am also pleased to welcome the newest addition to our leadership team, Jane Henderson, our CFO, coming to us with extensive healthcare, investment banking, biopharmaceutical management, and board experience. Many of you have known or recently met Jane since joining our team. And I am excited to have her on board. We have also recently added two new board members, Wendy Dixon and Glenn Pierce, who bring significant industry expertise and insight that are highly complementary to that of our existing board members.

Now before turning the call over to Bernard and Jane, I want to underscore the transformative years ahead for the company beginning with the announcement of this year's goals. In fact, if we fast forward just 24 months, we anticipate that our Parkinson's disease program will be advancing through registration studies, three additional programs will be in the clinic, and lead candidate selection will occur for at least one additional program.

Specifically for this year, however, we will provide six-month safety and motor function data from Cohort 3 as well as longer-term safety and motor function data from Cohorts 1 and 2 from our ongoing Phase 1b trial. This will occur in mid 2017. We will initiate a double blind placebo controlled trial for VY-AADC01 for advanced Parkinson's disease during the fourth quarter of 2017.

Data from Cohorts 1 through 3 and the soon to start posterior trajectory study will help inform the design of this study. We will also file IND for VY-SOD101 during the fourth quarter of this year and file two other INDs for our gene therapy vectors for Huntington's disease and Friedreich's ataxia within the next 24 months.

In addition, we remain committed to pursuing additional business development activities. We have already demonstrated an ability to transact such transformative deals such as with our Sanofi Genzyme collaboration. And we are pursuing additional types of deals around some of our unpartnered programs and platform capabilities. In addition to these well-defined and important goals for the company, we remain committed to investing in our core competencies or pillars, our people, our pipeline, our vector engineering platform, and our manufacturing capabilities.

With that, I'll now turn it over to Bernard who can discuss further progress with our Parkinson's disease program.

Thank you, Steve, and good morning, everyone. As Steve mentioned, the interim results we provided in December for VY-AADC01 represented an important milestone for the program providing what we believe is early proof of concept that well-tolerated an accurate onetime delivery can increase AADC enzyme activity in the putamen, enhance the patient's response to levodopa while delivering durable and clinically meaningful improvements in measures of motor function. Although we underscore that our study was not placebo-controlled, the dose-dependent improvements in biomarkers indicating an enhanced response to levodopa that markedly reduced levodopa doses post versus pre-treatment with VY-AADC01, especially in Cohort 2, and the improvement in motor symptoms observed at these doses are very encouraging. This was especially evident in Cohort 2 patient diaries were on time increased by 43% or 4.1 hours at 12 months with a 48% or 2.2 hour reduction in diary off-time from a baseline of only 4.2 hours. Importantly, decrease in off-time in Cohort 2 corresponded with meaningful reductions in troublesome dyskinesia; so patients were spending there on-time in a better state, if you will.

Importantly, these durable improvements in motor function occurred with a substantial 34% or over 500 mg reduction in Cohort 2 in average daily doses of oral levodopa and related medications from a baseline of over 1600 mg per day. This speaks right to the goal of our program to turn back the clock to when patients were more responsive to levodopa, requiring lower doses and achieving improvement in motor function. This is equally compelling in our opinion because oral levodopa doses were not reliably reduced in past gene therapy trials although direct comparisons must be made with caution.

And we are thrilled to be able to present these data at the upcoming American Academy of Neurology meeting in Boston as part of an emerging or late-breaking session taking place Tuesday evening April 25th. This is the 69th annual meeting of the AAN, which is the world's largest assembly of neurologists bringing together more than 10,000 neurology professionals across the globe.

As Steve mentioned, we're in the final stages of dose and delivery optimization with VY-AADC01. And by the middle of this year, we will have sufficient evidence to design and begin implementing our double-blind placebo controlled trial.

We recently completed dosing all five patients in Cohort 3. By increasing the concentration of vector, patients in this cohort received up to a threefold higher total dose of VY-AADC01 and Cohort 2, and the neurosurgeons are clearly gaining experience administering VY-AADC01 as evident by the increase in surgical coverage of the putamen achieved in Cohort 3 of 42% compared to 34% in Cohort 2 with similar infusion volumes.

We are very encouraged by the increased surgical coverage of the putamen with VY-AADC01 due to its high correlation with increased AADC enzyme activity. The consistency of coverage between patients in the overall favorable safety profile observed in this trial is equally encouraging. Cohorts 1 through 3 employ a transfrontal or top of the head trajectory of VY-AADC01 into the putamen.

As a final step towards optimizing dose and delivery, we will soon start a planned study using a posterior trajectory that aligns the infusion of VY-AADC01 more closely with the anatomical structure of the putamen. This could result in a much higher total volume of coverage of the putamen and also a higher total dose of VY-AADC01 up to 9.4 x 10 to the 12th vector genomes, representing a twofold higher total dose than patients in Cohort 3 and up to a six-fold higher total dose in patients in Cohort 2. We will soon activate two additional clinical trial sites in the U.S. with an additional site initiation expected in Poland soon. And we are excited to begin dosing the first patient in the coming months.

As a reminder, the dose and volume covered in Cohort 2 and the initial data we generated from the interim results from the Phase 1b study are well within the goals we set out to achieve and are already yielding clinically meaningful results. The data we gathered from Cohorts 1, 2, and 3 during the middle of this year, as well as initial data from the posterior trajectory study, will help inform the design of our next study, a double blind placebo-controlled trial in advance patients with Parkinson's disease. We look forward to updating you on the progress of this program in the coming months.

And with that, I will pass the call over to Jane, who can walk you through our financials in more detail.

Thank you, Bernard, and good morning. I'll spend the next few moments reviewing the financials and guidance before we move to Q&A. Voyager reported a GAAP net loss of $14.7 million or $0.57 per share for the fourth quarter ended December 31, 2016, compared to a GAAP net loss of $8.8 million or $0.67 per share for the same period in 2015. The company reported a net loss of $40.2 million or $1.59 per share for the full year ended December 31, 2016, compared to a net loss of $38.3 million or $9.14 per share for the same period in 2015.

Collaboration revenues of $2.4 million for the fourth quarter of 2016 compared to collaboration revenues of $4.9 million for the fourth quarter of 2015. Collaboration revenues reflect Sanofi Genzyme's recognized payments for research and development services, and decreased year-over-year mainly due to the de-prioritization of the development of VY-SMN101 for SMA, as well as a reduction of certain services provided by Sanofi Genzyme.

R&D expenses of $12.7 million for the fourth quarter ended December 31, 2016 compared to $9.2 million for the same period in 2015. The increase in R&D expenses year-over-year for the quarter and full year was largely due to expenditures associated with the development of Voyager's clinical and preclinical pipeline, product engine, and personnel costs.

G&A expenses of $3.5 million for the fourth quarter ended December 31, 2016 compared to $3.2 million for the same period in 2015. G&A expenses of $13.3 million for the year ended December 31, 2016 compared to $9.9 million for the same period in 2015. The increase in G&A expenses was primarily due to personnel costs to support Voyager's growth and facility costs.

Total cash, cash equivalents, and marketable securities as of December 31, 2016 was $174.4 million, and the company has no long-term debt.

Now turning towards guidance. As we entered 2017 with the exciting progress of the lead and pipeline programs as Steve and Bernard have discussed and with the ongoing investments in manufacturing and to the Vector product engine, we expect to end 2017 with total cash, cash equivalents, and marketable securities of approximately $90 million to $100 million. We continue to project that our existing cash, cash equivalents, and marketable securities will be sufficient to fund operating expenses and capital expenditure requirements into 2019.

With that, we would like now to open the call up for questions. Operator?

(Operator Instructions) We'll be taking our first question from the line of Christopher Marai from Nomura. Your line is open.

Hi. Good morning. Thanks for taking the questions and congrats on the AAN abstract. So, really, I wanted to maybe circle back on two things regarding the potential pivotal trial. Number one, maybe could you give us a little bit of guidance about the size of the trial you're thinking. Obviously some Phase 3s could be in that 200-patient range. And then how many sites? As well as do you anticipate doing PET imaging as part of this trial and specifically to get an idea of duration of expression? Or should we be looking at a continued sort of follow-up from the Phase 1 trial? Thanks.

Yes, thank you. Thanks for the question. So what's important is we have all the pieces in place to learn what we need to know to plan that trial. So we'll get the Cohort 3 data towards the middle of the year. We're also initiating the posterior delivery study. And so, together, that'll help us figure out dose as well as what the optimal surgical approach is.

In terms of additional discussions around that, we're obviously talking with our partner, Sanofi Genzyme, as well as regulators to fully understand what will be required for the registrational studies. We've previously talked about approximately 120 patients and our thinking of that hasn't changed. But we'll be able to provide more guidance and information around that in the second half of the year as we get that Cohort 3 data in the post-year delivery and have those conversations.

Regarding the PET scans, we absolutely plan to continue doing the fluorodopa PET scans going forward. It's an important biomarker that will show evidence of enzyme activity. We also expect to continue to repeat those scans in some of the patients that we've already dosed to demonstrate the durability.

Great. And then just on that point about Cohort 3, when we think about how the surgical procedure is improving with physicians, how do you look to control that procedure in the Phase 3 or pivotal trial? Is that going to add up any time to the timelines to maybe get sites prepped and then the surgeons ready in terms of their ability? Thanks.

Yes, thanks for the question. That's really an important part of the studies that we're doing right now, which is to get the surgeons experienced with doing these with understanding how much coverage they're getting. So this current posterior trajectory study as well as the prior study with Cohorts 1 through 3 has really given us the surgical experience. And we'll continue to do surgical training, and make sure that before they start the registrational trial that they have adequate surgical experience.

Yes. And, Chris, this is Steve. There'll be a limited number of sites. We haven't announced how many. But as you know we're going to have a number more in place very soon. These are the same surgeons that do DBSs, these are stereotactic surgeons. There will need to be some cross training, and we're already doing that from site to site already. So we think we're going to be in pretty good shape to get this up and running. And as evident from our data, even now the surgeons are getting better at actually doing the procedure. And so, we're optimistic that we can pull this off with a modest number of sites.

Our next question comes from the line of Jeff Chen from Cowen and Company. Your line is open.

Hi. Good morning. Thank you for taking my questions, and congrats as well on the AAN abstract. Maybe for Paul or Steve, for the AAN abstract or presentation, are we expecting to see any additional data disclosure versus what we saw already in December?

So, we'll be presenting an overview of the data that we released at the end of the year. If you recall, the data at the end of the year had all five patients at 12 months from Cohort 1, and three of the five had made it to that time point for Cohort 2. Those additional two patients will not have completed the 12-month follow-up by the time of AAN. So we'll be presenting that later, perhaps with the Cohort 3 data, in the middle of the year. We will however be providing some additional data on some of the other endpoints on disability, on quality of life, and some non-motor measures. So we'll be flushing out the dataset and showing how it relates to the top line data we presented in December.

Great. That's very helpful. And in terms of the posterior trial that will be soon initiated, will you be disclosing data from that trial at mid-year? And can you tell us sort of how do you intend to evaluate coverage, I guess, versus the current administration method? And how do you decide which method to take forward from there?

Yes. So we'll be looking to update you on that posterior delivery study by around mid-year. What we hope to have is a sufficient number of subjects dosed so that we can tell you how those surgeries have gone and what kind of coverage we've gotten. And what we know from the data we've presented already is that the coverage that we have, like in Cohort 2, as well as the coverage we've presented in Cohort 3 looks like it's quite robust in terms of the clinical effect.

So the real question for this posterior delivery study is, yes, we may be able to get more coverage. But we're particularly looking for a more efficient surgery, so can we reduce the surgical time, can we get the same kind of coverage with only a single pass; whereas, in the sort of top-down approach, we've done two and, in some cases, three different infusions.

Thanks. And if I may, just one last one. So Cohort 3 data with the 42% coverage looks better than the Cohort 2 with 34%. So, at this point, is there any reason to think that the Cohort 2 administration and dosing should be moving forward rather than Cohort 3?

So, overall surgical coverage in Cohort 3 was a little bit better, 42% versus 34% Cohort 2. What we know from Cohort 2 already is that 34% coverage at that concentration yielded what looked like very robust clinical effects. And as mentioned, we'll get the remainder of that cohort in towards the middle of the year. Cohort 3, if you remember, had a three-fold increase in concentration. So we don't yet know how that will play out clinically. And the reason we're doing it is to make sure that we fully understand what the dose range is. As you know, we may see similar results but we've got to understand what the full range of the dose response is with that increase in concentration.

Yes. For most drug treatments you can imagine there may be too low a dose and there may be too high a dose, we're not sure. We don't anticipate any issues. We've not seen any major safety issues with Cohort 3 obviously or we would've reported those. We just want to find the optimal dose. And so, with Cohort 3 not only are we measuring coverage, and that is comparable -- a little higher, as Bernard said, than Cohort 2, but we're also increasing the vector concentration. So the total dose is at roughly 3X what it is in Cohort 2. Question is, what's the effect size look like? And is it better? What we'd like to emphasize, though, is what we're seeing already in Cohort 2 is clinically quite meaningful, and we're pretty happy with that dose and volume.

Thank you very much.

Our next question comes from the line of Jim Birchenough from Wells Fargo. Your line is open.

Yes, hi, guys. Let me add my congratulations on all the progress in the upcoming AAN presentation. Just following up on the surgical training question, how long does it take to train surgeons currently to dose the drug? And do you expect that all the surgeons that would enroll through this pivotal study would be trained in advance of the study? Or should we expect some lag? In fact, I think that's what one of the things people are trying to get at.

Yes, bottom line, it really takes a couple of cases. And the way we do it is we have the whole team go observe a case at an existing site and then we have our people present for their initial cases. So we do expect, as Steve said, that we will really have our surgical sites, by and large, trained prior to starting the registrational studies. And that's one of the goals of these unblinded studies that we have going now is to make sure they're trained, experienced. But we really understand now if we need to add a surgical site how to do that and how to do this training. It's pretty straightforward as we've said. It's observation, and then we make sure that we're present for their initial cases, and we monitor ongoing quality.

And then just in terms of the posterior delivery study, I guess beyond improved efficiency of the surgery, would there be any point to that if you don't see a dose effect between Cohort 2 and Cohort 3? And I guess as we think about coverage going from 34% to 42% and a three-fold increase in concentration, if that doesn't really make a difference in Cohort 3, would there be a point, is there anything to read into your progress into that posterior delivery study?

So, the posterior delivery study is really about efficiency of the surgery. And I think what we're going to learn from the Cohort 2 and Cohort 3 is really the dose ranging with respect to concentration. And as Steve articulated, we're going to make sure that we understand the effects of that concentration and then decide if they're really not different, and we'll cross that bridge when we get to it whether or not to go with the lower concentration or the higher concentration.

Yes, yes. So, Jim, three questions to be answered with the posterior study. One is that posterior trajectory speed up the time of the surgery, simplify it a bit. By the way, it's been used before even with the device that we're using. So we're not just sort of picking that at random. And we hope that that will be the case and that could augur well for using that posterior trajectory in our pivotal trial. Second, of course, is volume coverage, which likely to go up, and that with the posterior trajectory, we have seen another study with increased coverage using that same trajectory in a different type of drug being delivered. And then, third, of course, is the increase in coverage times, concentration, and total dose. And this does increase the effectiveness or efficacy of the treatment. So the three questions being addressed, any one of those, we're positive would allow us then to incorporate that trajectory into the pivotal trial.

And maybe just one final one, if I could, Steve, just on the SOD1 opportunity. I think that mutation affects maybe 2% of ALS patients. So could you talk about just the commercial opportunity or just the addressable market for SOD1 silencing approach?

Yes. For the patients that have SOD1 ALS, that mutation, is a relatively modest number. It's 2% to 3% of all ALS patients; about 20% of the heritable form, the 10% of ALS patients that are monogenic in inheritance. So it's a relatively modest form. It is a very bad disease. It's uniformly fatal. Median survival is about two years. So our goal now, Jim, is really can we silence and really prolong life in a big way to prevent people from, for example, having to go on ventilators and have all the kinds of upper motor neuron respiratory issues that occur with this disease.

Now, one other factoid is that there are folks that believe and some data that suggest that misfolded SOD1 may be downstream and the more sporadic forms of the disease as well. We are not necessarily going after those initially. We're going after once where we know that the mutation exists, that this is dominantly inherited disease from parent-offspring, et cetera. But it is a modest -- relatively modest number of subjects.

Great. Thanks for taking the questions.

Our next question comes from the line of Katherine Breedis^ from Stifel. Your line is open.

Oh great. Thank you for taking my questions, and congratulations as well on your continued on-track progress and Bernard and Dinah's promotions. I just wanted to hear your thoughts, if you could, about the evolving competitive landscape in Parkinson's disease both in terms of what we're seeing in deep brain stim, perhaps any feedback on St. Jude's new Infinity DBS platform, new therapeutics and development such as SAGE-217, and also if you have any insights on where UniCare may be standing currently and their gene therapy program?

Yes. So in terms of the evolving landscape, I think DBS is sort of making incremental improvements. I think, overall, we're very pleased with the approach we're taking relative to DBS, in terms of this being one-time durable with no indwelling hardware. So, DBS has been moving along, well-established therapy with those incremental improvements. I will let Steve comment in terms of the SAGE pipeline.

Well, let me -- Katherine, before I get to 217, what we see happening out there is some incredibly good news for patients with Parkinson's disease. We are seeing effects of smoothing out the PK of levodopa/carbidopa combinations as being quite interesting; still early days in terms of placebo-controlled trials. But what we see is a treatment -- our treatment being quite complementary to all of those ways of delivering levodopa because obviously smoothing out pharmacokinetics is very, very important, but in our case, increasing the brain's ability to respond to the medicine, particularly just the motor symptoms of the brain.

So we look at these in combination potentially as getting very, very good control over the motor symptoms of the disease. And the other treatments, including SAGE-217, yet to be determined whether they have any efficacy at this point at all. But, again, we feel there is going to be a very important niche for our treatment to enhance the activity of a very well-established compound namely levodopa.

And really no major advances in terms of the addressable population in advanced Parkinson's disease, it would appear.

Not -- I think we are all -- yes -- no, I would agree with that comment. I think we're all going after that 100,000, 150,000, 15% of prevalent patients that have very difficult to treat, very advanced disease. And that's a big marketplace as you can imagine. So, I think there is going to be a room for a number of products. We also like the alternative formulations in delivery routes for levodopa because, again, we think that's complementary and synergistic with what we are attempting to do in the brain. And we know of no one else as competitive to what we're doing.

That's great. Thank you. And then with respect to manufacturing, do you have any updates for us in terms of how things are progressing as you move toward potentially starting a pivotal study later in 2017?

Making good progress week by week, month by month, but we're on track. We haven't gotten off track with respect to producing the VY-AADC01 GMP lot material for the pivotal trial. We have obviously already made progress on the ALS SOD1 vector as well because, again, we'll need that data for filing the IND late this year. So, so far so good.

All right. Thank you for taking my questions.

Our next question comes from the line of David Nierengarten from Wedbush. Your line is open.

Hi. Thanks for taking the question. I have maybe a little bit of a question on time line and regulatory pathway for the pivotal study. Let's say you decide on the back of the head, the posterior infusion for your pivotal study, I mean what are the chances that, that changes your time line a bit on initiating the Phase 3? Maybe you could walk us through if there's potential changes in time line because of the FDA meetings or any changing or thinking about new IRBs, just maybe if you can help us think about that time line? Thanks.

Yes. So the posterior trajectory -- so, I think this is one of the other questions was getting at as well. All right, it's simply a different trajectory to accomplish what we already showed with Cohort 2 and 3, which is to get good coverage of the putamen. As Steve mentioned, this posterior trajectory is used for other purposes. So, it's really a change in the surgical angle. But it doesn't fundamentally change the risk benefits nor do we expect that it will change the time line. So, IRB's regulatory issues really aren't any different based on the trajectory that we're taking.

Got it. I just wanted to double-check on that. Thank you.

Okay, I believe that --

Ladies and gentlemen -- sorry, go ahead, sir. Sorry.

I was going to say I don't think there are any other questions. This concludes our call. Let me thank everyone for attending morning and for your very thoughtful questions. We look forward to updating you more on our progress. It will be a busy year for Voyager. Thank you.

Ladies and gentlemen, thank you again for your participation in today's conference. This now concludes the program and you may now disconnect at this time. Everyone have a great day.