Qiagen NV (QGEN) 2025 Q4 法說會逐字稿

Ladies and gentlemen, thank you for standing by. I am Katie, your call operator. Welcome, and thank you for joining Qiagen's fourth quarter 2025 earnings conference call webcast. (Operator Instructions). At this time, I'd like to introduce your host, Daniel Wendorff, Vice President of Head of Relations at Qiagen's. Please go ahead.

Thank you, operator, and welcome to our call for the fourth quarter of 2025. We appreciate your time and interest in Qiagen. Joining on the call today are Thierry Bernard, our Chief Executive Officer; and Roland Sackers, our Chief Financial Officer. Also joining us is Dr. Domenica Martorana from our Investor Relations team.

As always, today's call is being webcast live and will be archived in the IR section of our website at www.Qiagen.com, where you can find the press release and presentation accompanying this call. Please also note that this call will include forward-looking statements.

Actual results may differ materially from those projected due to a number of factors outlined in our most recent Form 20F and other filings with the US Securities and Exchange Commission. We will also refer to certain financial measures not prepared in accordance with US.

Generally Accepted Accounting Principles or GAAP that provide additional insights into our performance. Reconciliations to the most directly comparable GAAP figures are in the release and presentation. All references to earnings per share refer to adjusted diluted EPS. With that, let me hand the call over to Thierry.

Thanks a lot, Daniel. Hello, and good morning, good afternoon or good evening, depending on where you are in the world, and thank you once again for joining us. I am very pleased today to confirm that Qiagen continued to perform and delivered a solid finish to 25 with results in the fourth quarter again above outlook.

We exceeded our targets for both sales and adjusted earnings, once again placing Qiagen among the fastest-growing companies in our industry. This reflects continued execution across the business and the trust our customers place in us even in a challenging environment.

I also want to recognize the dedication of our teams around the world. Their work has been essential in delivering those results. So let me walk you through our key messages for today.

First, we exceeded our outlook for the fourth quarter, and we also delivered solid full year 2025 results at the high end of our expectation with adjusted earnings again above our guidance. Net sales were $540 million in the fourth quarter.

growing 1% at CER and exceeding our outlook for flat sales development against the fourth quarter of '24. Adjusted diluted EPS was $0.62 at constant exchange rate, exceeding our outlook of about $0.60 constant exchange rate again.

For the full year of 2025, net sales were $2.09 billion, up 5% at CER and at the upper end of our outlook of about 4% to 5% growth. Adjusted diluted EPS increased to $2.40 at CER. This was above our outlook, which we increased twice during the year and reflects our ability to deliver in a challenging environment.

Second key message, we reached important milestones across our portfolio. We want to highlight here that across our growth pillars, sample technologies, QuantiFERON, QIAstat, QIAcuity and Qiagen Digital Insights.

They all achieved combined sales of $1.49 billion at CER in '25, delivering 8% growth at CER again. The current trajectory keeps us on track for at least $2 billion in combined sales from our growth pillars by 2028. This reflects continued demand across our portfolio and the increasing relevance from areas where we have decided to invest for the long-term growth.

Sample Technologies continued to grow with sales up at CER in the fourth quarter and 2% CER gain for the full year. This is an indication of the demand for automated consumables as laboratories continue to push to automated sample prep.

In addition, during the year, we completed the acquisition of Par Biosciences extending sample technologies into single cell analysis and adding exposure to this very rapidly scaling field. QuantiFERON delivered continued growth with sales up 5% at CER in the fourth quarter and 10% CER again for the full year, supported by ongoing conversion and a large and still underpenetrated latent TB testing market. We are executing here on a clear strategy to drive further conversion.

QIAcuity our digital PCR solution delivered double-digit growth in consumables and an installed base that exceeded 3,200 instruments globally since we launched it. as digital PCR continues to gain relevance in applications requiring high precision and QIAstat grew 15% at CER in the fourth quarter and 24% CER for the full year 2025.

Growth was supported by menu expansion and the growing installed base that exceeded 5,200 instruments. Last, our bioinformatic business, Qiagen Digital Insights, delivered continued growth in 2025, supported by demand across both Discovery research and academia and clinical customers and the integration of Genoox, which further strengthened our clinical interpretation offering.

Third message for today. We made further progress on profitability and cash flow while continuing to execute on disciplined capital allocation.

For 2025, our adjusted operating income margin increased 80 basis points to 29.5%, reflecting continued efficiency gains across the business. Those improvements more than offset headwinds from tariffs or adverse currency movements and the previously disclosed dilutive impact from recent acquisitions. We also generated solid free cash flow of $453 million in 2025.

This supported investment into the business, including the rollout of our upgraded ERP programs. At the same time, we continue to return capital to shareholders. Since 2024, Qiagen has returned more than $1.1 billion to shareholders to date and introduced an annual dividend payment while pursuing selective bolt-on acquisitions to support our future growth.

So as we are heading into 2026, we clearly remain focused on execution, disciplined cost management and continued investment into our growth pillars. Before handing over to Roland, I would also like to briefly acknowledge the change in our Supervisory Board.

We are very pleased to welcome Mark Stevenson, who joined our Supervisory Board in January. Mark brings deep operational and global life sciences experience and we really look forward to working with him. At the same time.

I would like to sincerely thank for his many years of contribution to Qiagen step down from the Supervisory Board after taking on a new leadership role at Memorial Sloan Kettering in New York, but we are grateful that he will continue to serve Qiagen as Chair of our Scientific Advisory Board. With that, I'll hand it over to Roland for more details on the financials.

Thank you, Thierry. Hello, everyone. Thank you as well for me for joining our call. We are pleased with our performance in the fourth quarter and full year as we delivered results above our outlook for the fourth quarter on both sales and adjusted diluted EPS at constant exchange rates. 2025 was overall another solid year for Qiagen in terms of execution and delivering on our commitments.

Let me frame our performance around three key messages.

First, we delivered solid results with sales for '25 at the high end of our outlook with continued strength in consumables and our growth pillars amid a cautious funding and capital spending environment.

Second, we improved profitability expanding the adjusted operating income margin by 80 basis points over 24% on efficiency gains and operational discipline. These actions more than offset material headwinds from tariffs and currency movements. And third, we continue to deploy capital in a disciplined manner.

We are investing to support future growth while increasing returns to shareholders. Our strong free cash flow enabled us to make investments into bolt-on yields like Parse and Genoox while also returning over USD1.1 billion to shareholders since 2024.

With that context, let me focus on the financial drivers behind our results. For the fourth quarter, net sales grew 1% CER and exceeded our outlook for flat sales development against '24.

Adjusted diluted EPS was $0.62 at CER and above our outlook for about $0.60. For the full year, sales increased 5% CER, and this was at the high end of our outlook. Our growth pillars delivered 8% CER growth for the year and reached our goal for $1.49 billion of combined sales at CER.

So we are on track to achieve our '28 goal for at least $2 billion of combined sales from these products. Adjusted diluted EPS for the full year were $2.40 at CER for '25, which was $0.12 above our initial outlook for the year and compares with $2.18 in '24.

Let me now provide some additional insights into sales trends for the fourth quarter and for '25. Among our product groups, Sample technologies delivered mid-single-digit CER growth for the fourth quarter and this was complemented by low single-digit growth in Diagnostic Solutions and Genomics, while sales in our PCR product group declined at a single-digit rate.

In Sample technologies, sales growth in the fourth quarter was driven by higher demand for automated consumables used on our instruments, and results are included first-time contributions from the past acquisitions that was completed in December.

For the full year, Sample technologies delivered 2% CER growth in line with our expectations as trends improved over the course of the year. In Diagnostic Solutions, sales increased 1% in the fourth quarter.

QIAstat-DX sales were up 15% CER, driven by double-digit growth in consumables as we continue to benefit on the full core menu in the US, '25 delivered 5% CER growth and supported by continued conversion from the skin test. In the PCI product group, sales declined 9% CER in the fourth quarter.

Consumables for use on the QIAcuity Digital PCR system continued to deliver double-digit growth as we continue to place over 100 instruments per quarter in a challenging capital spending environment. Sales of other PCR consumables, however, declined due to factors that included the challenging funding environment and lower OEM contributions compared to the '24 period.

In the genomics and NGS Product Group sales grew 2% CER in the fourth quarter, driven by double-digit growth in the Qiagen Digital Insights Bioinformatics business.

At the same time, sales of NGS consumables were under pressure. Turning to the regions in the Europe, Middle East, Africa region led the performance and were up 5% CER for the fourth quarter. top-performing countries included Belgium, the Netherlands, Spain and the United Kingdom. In the Americas, sales declined 1% CER with results in the United States being flat at constant exchange rates.

A factor reflecting this was the US government shutdown. In the Asia Pacific, Japan region, sales were flat in the fourth quarter. Results in China declined at a low teen CER rate for the fourth quarter over the year-ago period. But keep in mind that this country represents only about 4% of total sales in '25.

Turning to the full year results. For '25, the adjusted operating income margin was 80 basis points to 29.5% compared to '24. And this was achieved despite facing about 120 basis points of combined headwinds from tariffs and adverse currency movements.

In other words, the underlying profitability strengthened meaningful during '25 -- excluding these external headwinds, the margin expanded by roughly 200 basis points in '25, and this was well above our initial target for at least 150 basis points of improvement and this was before the tariffs were announced.

This performance reinforces our confidence in exceeding our '28 target for a margin of at least 31%, and we are reviewing this target with plans to provide an update.

For the full year, we raised our adjusted EPS outlook price during '25 and ultimately delivered results of $2.38 on a reported basis and results at CER of $2.40. Turning to cash flow. Operating cash flow of '25 was $654 million compared with $674 million in '24, reflecting strong earnings generation.

The results for '25 also absorbed about $54 million of cash payments for the efficiency initiatives. Free cash flow was $453 million for '25, reflecting higher capital expenditures related primarily to IT investments that included the SAP system upgrade.

We continue to deploy capital in a disciplined manner, balancing investment in the business with returns to shareholders. As you know, we completed the purchase of Parse in December while in January, we returned USD 500 million to shareholders through a synthetic share repurchase.

On a pro forma basis, net leverage stood at about 1.3times net debt to adjusted EBITDA in January '26 as our leverage improves. Net financial flexibility to support continued investment in organic growth and targeted both on acquisitions while also increasing returns to shareholders and that also includes our annual dividend payments planned again from mid-'26.

Taken together, our '25 performance reflects solid execution on sales growth margin expansion and disciplined capital deployment as we look for another year of solid profitable growth in 2026.

With that, let me hand the call back to Thierry.

Thanks a lot, Roland. And let me share with you a bit of perspective on our product portfolio. Starting with Sample technologies, as you know, a key focus for Qiagen. In December, we completed the acquisition of Parse Biosciences, extended our sample technologies portfolio into single sales analysis. Parse as a scalable differentiated chemistry that strengthens our Sample to Insight workflows and opens a long-term growth opportunity.

Recent launches such as ever code wall blood fixation enable immediate fixation at collection and extend Parse's reach into translational and clinical research. Alongside this expansion of acquisition, we execute on our next-generation automation road map. In 2025, we successfully launched QIAsymphony connect took initial orders for QIAsprint Connect and remain on track for the launch of QIAmini.

Within Sample technologies, strategic high-value applications to continue to gain traction. One example is our liquid bios sample preparation portfolio, which grew by more than 30%, reflecting this increasing relevance in Sample Technologies.

Despite cautious capital spending, our sample technologies installed base grew to around 31,400 cumulative placements.

Looking 2026. We will launch QIAsprint Connect and QIAmini together with additional kits, supporting automation across more than 30 applications for QIAsprint Connect and more than 15 applications for QIAmini. Over time, this will increase instrument and recurring consumables. Full IVDR launch for QIAsymphony Connect remains on track for mid-2026.

QIAsprint Connect is planned for February and QIAmini for fall of 2026. Moving to QuantiFERON, where we continue to invest enabling laboratories to manage rising testing volumes with higher throughput and more efficient workflows.

A key step here is the next generation of QuantiFERON TB Gold Plus second assay developed in collaboration with last year, we completed the European launch of this high throughput assay. This new generation of chemistry enables laboratories to test up to 75% more patients per hour while reducing turnaround time by around 25%.

Building on this European launch, we are planning a US launch of this higher throughput chemistry in 2026. In parallel, we are also exploring how AI-based approaches can support clinical decision-making in latent TB infection, particularly in the context of increasing testing volumes and the need to guide preventive treatment.

Turning to QIAstat, where we expanded the menu and the installed base over the year. In '25, we submitted our first blood culture identification panels for clearance in the US.

and in Europe. These submissions extend QIAstat diagnostic into bloodstream infections and sepsis-related applications, building on panels across respiratory, gastrointestinal and meningitis testing. We also expanded the installed base with cumulative QIAstat placement exceeded 5,200 instruments worldwide in 2025.

We continue to invest in new panels particularly a panel for complicated urinary tract infections where Qiagen will be the first with a comprehensive syndromic solution. At the same time, we are also advancing our work on pneumonia panel.

In parallel, we continue to develop companion diagnostics with our pharma partners on QIAstat. Next, QIAcuity Digital PCR continue to see steady adoption as customers convert from QPCR and NGS to digital PCR. In '25, cumulative QIAcuity placements exceeded 3,200 systems worldwide.

This reflects continued uptake of digital PCR where higher precision, absolute quantification and more standardized results are required. Our focus remains on expanding the assay portfolio and improving workflows.

Gene expression remains an important use case for QIAcuity alongside applications such as cell and gene therapy.

Automation is another key focus with the launch of a nanoplate handling solution codeveloped with Hamilton on the platform. enabling walkway automation and more standardized workflows for regulated environments. Last, Qiagen Digital Insights, where we continue to develop bioinformatics portfolio to ship both research and clinical use. This includes progress with Franklin.

Following the Genoox acquisition integrated Qiagen's curated knowledge with AI-enhanced workflows to support genetic interpretation and clinical reporting. AI has been embedded across QDI, and we are continuing to support research, data science and commercial solutions by improving workflows, consistency and the use of high-quality genomic content.

For the next two years, our focus is to continue developing at least 14 AI-enabled software solution within DI. We are also preparing to integrate single sale data sets from past Biosciences into the QDI portfolio, connecting single-cell data with downstream analysis to support predictive modeling across research and transnational.

And now back to Roland for the outlook.

Thank you, Thierry. Let me now provide some additional perspectives on our outlook for '26 and for the first quarter. Our ambition remains to deliver solid profitable growth as we continue to navigate a challenging macroeconomic environment.

Against this backdrop, we remain on track toward our '28 ambitions of around 7% core sales CAGR from '24 to '28 and adjusted operating income margin of at least 31%, at least $2 billion of sales from our growth and sustained shareholder returns having already delivered more than $1 billion since '24. For the full year '26, we are initiating an outlook for sales growth of at least 5 percentage point CER and adjusted earnings per share of at least $2.50 at CER.

Turning to the first quarter. We expect net sales growth of at least 1% CER compared with sales of $483 million of the first quarter of '25. The growth rate for the first quarter compared to the full year target reflects temporary factors.

First, we are absorbing the year-over-year impact from the discontinuation of NeuMoDx and, which represents a headwind of about $10 million or about 2 percentage points in the first quarter. We will see the same impact in the second quarter of '26, but then it rolls off since these products were discontinued in June '25.

Second, and like others in our industry, we continue to see cautious life science customer spending trends carrying over from '25 into the beginning of '26. We have reflected an estimated impact of about $10 million in the first quarter or about 2 percentage points of growth.

At the same time, we continue to expect an improvement in the funding environment over the course of the year. And third, QuantiFERON faces a strong comparison to results in the first quarter of 25% when sales was 16% CER and supported by tender activity in the Middle East and Latin America.

As a result, we expect QuantiFERON to grow at a low single-digit CER rate in the first quarter of '26, representing a headwind of about $6 million to $7 million or about 1 percentage point of headwinds through a normalized full year run rate for '26 of about 6% CER growth.

Turning to earnings. Our outlook for the first quarter is for adjusted earnings per share of at least $0.54 CER compared to -- with $0.55 in the first quarter of '25. Operational efficiency remains a priority in '26 and continues to support profitability.

At the same time, earnings for the first quarter of '26 are expected to absorb the $0.02 dilutive impact of the past acquisition as well as an adverse impact of about $0.02 from the US tariffs that were implemented later in '25.

For the first half of '26, we currently anticipate sales growth of about $0.02 to $0.03 CER, followed by an acceleration in the second half of the year. The acceleration in the second half reflects various factors, and let me provide a bridge to our full year outlook.

As a first point, the comparison impact from the roll-off headwinds from NeuMoDx and contributes about 2 percentage points of incremental growth. New product launches, including the three new instruments as well as new offerings for QIAstat-Dx and QIAcuity are expected to add an additional 2 percentage points of growth.

As a next point, acceleration year-over-year growth from QuantiFERON starting in the second quarter of '26 is expected to provide about 0.5 percentage point of incremental growth and improving US

academic and governmental funding trends together with a higher contribution from parts in the second half are expected to add approximately another 0.5 percentage points. Taking together, these factors fully explains the bridge from approximately 1% growth in the first quarter to at least 5% growth for the full year.

Turning to margins.

We expect adjusted operating income margin to remain at about 29.5% of sales as efficiency gains and broad-based growth are expected to offset margin headwinds of about 160 basis points from the past acquisition, adverse currency movements and tariffs. This underpins our full year '26 target for adjusted EPS of at least $2.50 CER and the step-up from our '25 results.

Let me also provide some perspectives on the currency trends against US dollar. For the full year, our currency expect tailwind of about 1 percentage point on sales and a neutral effect on adjusted EPS results. For the first quarter, we currently expect a tailwind of about 2 percentage to 3 percentage points on sales and a neutral impact on adjusted EPS results.

Overall, we have taken a prudent approach in setting our outlook, reflecting current market conditions and known headwinds while positioning Qiagen to continue to rank among the fastest-growing companies in our sector.

I would like to now hand back to Thierry.

Thank you, Roland. And before we go to the Q&A, let me quickly summarize our key messages for today. First, looking back on 2025, Qiagen delivered another solid quarter and closed the year with consistent execution across the business.

The growth pillars grew at 8% CER and this is among the fastest in our industry. This once again reflects the strength and balance of our portfolio across life sciences and diagnostics.

At the same time, we remain obviously mindful of our environment. We continue to operate amid macroeconomic uncertainty, cautious capital spending and ongoing volatility, which requires discipline and focus in how we manage the business.

Looking ahead, our growth pillars are positioned to continue growing in 2026, supported by a very strong pipeline of new product launches and portfolio additions. While we continue to see a cautious life sciences funding environment and softer capital spending we expect conditions to improve gradually over the course of the year.

Keep in mind that our outlook for the first half of 2026, is clearly impacted by many base effects from last year, and we are relentless about the contributions ahead from the upcoming new product launches.

We expect our growth pillars combined to step up again in '26, targeting growth of around 9% at CER. Sample technologies is targeting sales of around $720 million CER. QuantiFERON, around $535 million. QIAstat around $160 million. QIAcuity around $100 million and QDI around $125 million.

As you clearly see, our focus remains on disciplined execution and operational excellence. In 2025, adjusted diluted EPS grew to $2.40 at CER, and we continue to return capital to shareholders. With the completion of the $500 million share repurchase at the beginning of 2026, we delivered on our commitment for solid profitable growth.

Those results are keeping us on track against our 2028 ambitions of about 7% sales CAGR, at least 31% adjusted operating income margin at least $2 billion of sales from our growth pillars and the shareholder returns of at least $1 billion, which, as I just said, we already exceeded. With that, I'd like to thank you again for your attention and hand back to Daniel and the operator for the Q&A session.

Thank you very much, Thierry. Operator, I think we can now go into the Q&A session.

(Operator Instructions) Tycho Peterson, Jefferies

Hey, thanks. I want to start out on some of the new product launches. QIAcuity, QIAstat, adding 200 basis points to growth in the back half of the year. Maybe just give us a little more color on the products? Is this about new markets or deeper penetration? And what gives you confidence that will contribute to growth out of the gate?

And then on QIAcuity, help us bridge to the $250 million target by 2028 because you have missed your targets there in the last couple of years. So talk about what you think really gets you to that target by 2028? And then just one follow-up on QuantiFERON, the assumptions for the back half of the year bridge. I think you previously said growth targets would include competitive entry. Is that still baked in and by how much?

Thank you, Tycho, and I will try to make sure that I'm not forgetting any of your questions. On the new products and the impact of at least 2% extra growth from H2 to compared to H1 of '26.

The way you need to see it is that at least three of those new launches are opening completely new markets from Qiagen. Of course, the new panel of QIAstat, the blood culture panel is opening new segment of customers, new needs. So it's an add-on.

In Sample tech, QlAsprint marks the entry of Qiagen into very high sample technologies, where we are not at the moment, therefore, new market. calamine is offering or will offer automation for low throughput labs or very small volume research, new markets.

So you can see that it's justified and realistic to add growth in the second half of the year because of those impact. QIAsymphony Connect will be not only upgraded QIAsymphony, but probably also convince other customers to adopt this technology. So that's why we are confident in this number.

On QIAcuity, you are perfectly right, Tycho, over the last two years because our sales on digital PCR, are mainly directed at the moment in research and academia, we have disclosed that we have been impacted by a more sluggish environment of capital expenses in research and academia.

So that created a bit of delay in revenues coming from instrumentation from Digital Pass. The consumables have been good for the last three years, we systematically grew at double digits. But in three months, were a bit below our expectation. But again, what are we talking about here?

When we see -- when we say below our expectation, if I take 2025 as an example, we still put more than 500 new QIAcuity on the market. If you look at Q4, we put more than 100 systems in Q4, 100 new QIAcuity. Those systems will obviously generate consumables tomorrow.

So we have indeed given a target of $250 million of revenues by '28 for Digital PCR at Qiagen. We might have a slight delay because of the sluggish capital expense environment, but what is important to us is that we continue to grow, we capture new market and we grow consumables at double digit while still placing a significant number of instruments every year.

Now for QuantiFERON. We explained the profile of the growth for '26. H1 is impacted by base effect coming by tenders and significant contract in Q4 of '24 and Q1 of '25. You will see QuantiFERON picking up in Q2. And obviously, those base effects will progressively disappear.

And you'll see QuantiFERON accelerating to achieve probably above 6% growth, let's say, between 6% and 7% growth in 2027 -- in '26, I'm sorry, which is perfectly aligned with the target that we gave during our Capital Market Day in June '24, QuantiFERON will be $600 million revenues by 2028.

Jack Meehan, Nephron.

Thank you. Hi everyone. Thierry, I wanted to get your thoughts. There were headlines a few weeks ago around Qiagen as a potential deal target. Again, I was wondering what comments, if any, you can share on that.

Thanks for the question, Jack, and I was expecting a question on this. I mean it's fair to say that -- our market is still and will still going through consolidation.

That's point number one. At the same time, Qiagen is delivering and focusing on delivering on our solid plan for the coming years, the plan that we disclosed in New York in June '24, 7% CAGR on the top line, at least 31% EBIT margin, $2 billion from our pillars of growth. So this is where we are focusing.

At the same time, we do not comment on rumors we are always open for discussion that could create value for shareholders and I cannot say more at this stage.

Understood. And appreciate the execution has been really solid, and you still have your hand firmly on the wheel but also did want to ask about the CEO succession search. Just was wondering when you think might have an update on that?

What is important for the Board and for the company is to find the best person for the job. So we have a search ongoing, as we said in Q4 of '25, this is both an external and internal search. It's advancing very well, but we need to take the necessary time once again to find the best person for the job.

In the meantime, we do have a management fully dedicated to Qiagen. It's not only theory, it's the entire relegate committee and also 5,700 of Qiagen all over the world. We will obviously update you as we can progress.

Casey Woodring, JPMorgan.

Wanted to ask on the margin expansion piece. The bridge to 2026 didn't seem to include any operating margin improvement this year outside of the efficiency program, which will part in tariff headwinds unless I'm misinterpreting your comments there. So maybe just can you walk us through how you're thinking about organic operating leverage across the business and how some of the new product volume is expected to contribute to the bottom line this year?

As, again, I do think actually that '26 will be another significant margin improvement year for Qiagen because I think it's really fair to say that we do expect we announced headwinds from the acquisitions of Parse. As you know, that is an acquisition where we're doubling up on the R&D -- doubling down on the R&D investment.

So there's clearly a certain dilution for us to expect for this year, and that is around 100 basis points for 2026. In addition to that, we have a combined headwind again also from tariffs and FX in '26. So there will be a net margin improvement -- or gross margin improvement for around about 160 basis points for this year, which again will be compensated, as I said, from pass and tariffs and expected currency headwinds.

So 160 basis points, how does this break down? A larger part actually this year comes, and we talked about that in the past, from gross margin improvement. I would say probably somewhere between 75 and plus basis points in '26 comes from gross margin improvement.

Have in mind, you will see an acceleration, quite significant acceleration in Sample. And clearly, Sample preparation is also 1 of the product groups, which has a significant gross margin contribution to Qiagen.

So that should be helpful. And in addition to that, we still continue to see outstanding growth trend around QIAstat. And you also know that we in the past talked about that we're still running an underutilization in terms of production utilization for QIAstat.

So also here, better utilization will drive gross margin improvement. Last but not least, we still have ongoing 40 QIA efficiency program on the operational expense side, they all will contribute not only in '26 also beyond.

So again, we expect margin improvement this year. We expect to continue that in '27 '28. And as said in his remarks, we clearly do believe we will see a significant step up north of the 31%, which was announced for '28.

Okay, we'll leave it there.

Thank you.

Aisyah Noor, Morgan Stanley.

My one question is on China. So can you confirm if you're exposed to VBP or any large tender renewals that we should be aware about? And what's the kind of growth outlook embedded in your guidance?

Thanks for the question. Aisyah, we keep the same attitude and consideration towards China. As we have said for the last three years, it's not significant in our revenues anymore. Our exposure is 4% to China. It's a large market.

It's too large of a market to be ignored. At the same time, it's too specific and too politically driven as a market to make it an investment case. We are not specifically more impacted by VBP because VBP has been implemented across molecular solution at least for the last three years in China. So it's nothing new for us. Last year was negative.

We continue to think that China will be between low single digit to negative to a very base flat, and we do not expect in the current political situation, economic situation and market situation of China to see a return of growth in the visible future. But again, our exposure is very limited, as I said, 4% of sales.

Odysseas Manesiotis, BNP Paribas.

Firstly, on QIAstat. You finally have a complete high-volume platform during what seems to be a material year for replacing such instruments. Is it fair to assume that you do much better than the 600 placements you did in '26 -- in '25?

Well, I appreciate that always want more, but more than 600 placements in 2025, it's already a good performance. So I prefer to leave it like this. We grew at 25% for Q4, we grew at much more than double digit for '25. We gave you an objective of more than $160 million for '26, which shows again a double-digit growth. We are a solid number two in this market.

This is exactly what we wanted to achieve. And if we can beat our objective or new placement, we will do it. But let's execute first on the $160 million. Let's execute on the product launches on the market penetration, and that will be already good.

And a follow-up on QuantiFERON. Could you give us of additional color on the Q1 guidance here? I mean, is there any price component to your conservativeness there? And how exactly were these one-off tenders, given the low shelf life of the kit?

Yes. I think it's not a question of sales life. It's a fair question, but it's just a comparison quarter-on-quarter on deals that we have been able to include in ourselves. It's a base effect. If you look at Qiagen recent communication on QuantiFERON

it did include over the last 3 years, some press releases, some time of significant tenders in Middle East. The contract with Oman was one of them. In Latin America, the contract in Brazil was another 1 of them. So those are creating a base impact compared to Q1 2026 because of their date of signature or renewal. As Roland explained during his comments, growth of QuantiFERON for Q1 2025 was close to 16%.

We need to compare this with a normalized growth of QuantiFERON over the year, which is 10%. In other word, we grew in Q1 of '25, 6 points above the normal growth of Qiagen. It creates necessarily a base impact. This is not a conservative guidance. It's just a realistic guidance.

Regarding prices, we were very clear when we issued the guidance for QuantiFERON early '25. We know that competition will increase on that market. We factor that in our number $600 million for 2028.

And we always said that our plan commercially is to move even more customers to contract. This is good for the business. This is good for the franchise. If this sometimes goes with a bit of pricing flexibility, it's a good thing to do.

Michael Ryskin, Bank of America.

Great, thanks for taking the question, guys. I want to ask a little bit more in the 1Q outlook outside of QuantiFERON. You talked about some of the moving pieces there in terms of the comps, in terms of the new modes shutdown, things like that. I want to dive into your expectations for end markets. You had some comments on you expect end market improvement as you go through the year.

But maybe if you could just expand on that a little bit of how much of that is built into 1Q specifically, maybe as far as US government shutdown or broader markets in general? And just what's the degree of improvement you're embedding as you go through the year to sort of like hit that back half ramp?

So the first comment, Michael, is that the overall market, if I look at some of our main competitors' recent earning calls, we see that they are in the same ballpark of guidance for most of them, not to say all of them. It is clear, and we already said that last year that if we consider the funding environment especially for Research and Academia labs and especially in the US, we believe that the situation is better now than it was 6 months ago. Why? Because 6 months ago, most of the comments were targeting a significant decrease of budgets like NIH, for example. Now we know that we are going to be probably seeing a slight increase in '26 of the NIH budget, let's say, max around 1%.

This is good for the business. At the same time, we said today that we believe that many research and academia lab are still in a kind of wait-and-see attitude. Once they get more visibility, we believe and it's embedded partially in our H2 expectation, that capital expense, especially in research and academia will improve because they will have more visibility. we think that it's fair to assume that progressively throughout 2026, the total market can come back to a growth of mid-single digits.

Okay. That's helpful. And then maybe I can dig into Sample tech a little bit in the slides. I think you called out a $720 million target for 2026. Just to confirm, that includes part contribution in it of about $40 million.

And then just confirming that. And then the second part of that question would be just how much of that do you expect to be contribution from some of those new automation solutions in Sample tech. Is that a meaningful contributor to 2026 in that part of the portfolio? Or is that just going to take a little bit longer to ramp?

So you're perfectly right for your numbers. We said $720 million total sample tech. It includes indeed around $40 million contribution from parts. And as we discussed you and I yesterday, past contribution will be higher if you compare H1 to H2 for parts, we are probably at 40% for H1 and 60% for H2 in terms of weight in their revenues. So you're perfectly right on that.

Now if you consider the new launches, QIAsymphony Connect, QIAsprint Connect and QIAmini, they are fully embedded in the 2% extra growth coming from the new products that we are planning H2 to H1.

[Kavvia Deshpande, UBS].

Good afternoon. Thank you for taking my questions. Just a couple on QIAstat, please. So firstly, on the guidance for 2026. Is there anything you might be able to share on what you're assuming in that guide for the US respiratory in 2026? And then secondly, I think you shared a couple of years ago, that at the point of your last CMD, over 50% of QIAstat customers were using more than 2 panels.

Would you have any update on this, it would be good to get that just given you've done a lot of menu expansion since then?

That was our first question. I think we have seen that, again, the respiratory season was significant from December '25 to probably now, we'll see what is going to happen in the coming weeks. You perfectly, I believe that there are harsh winter conditions in the US as we speak, but it's too early to say. What I can tell you is that I believe that relator issues will remain significant for the years to come.

And that's why the respiratory panel on syndromic like QIAstat are so important. I think people are more aware, they are more aware of flu, whether it's A&B, RSV, obviously, COVID or other respiratory pathogen. So I believe that it's going to become a well-established panel and testing for the years to that's why it's key to have this panel.

And as you know, in the US, not only we have it in a long format, large number of pathogen, but we have it also in a short format more reduced number of pathogen. So to your second part of your question, what's the proportion of customers using more than one panel.

It's clear that the 50% continues to increase because that's the relevance of adding panel consequently year after year. And as you know, those panels are very coherent they address mostly infacious diseases laboratories. So yes, this number is improving as well.

Thank you. Perfect, thank you very much.

Harry Gillis, Berenberg.

Harry GillisAnalyst

I have two on the midterm guidance. Could you just confirm whether your target for 7% sales growth through to '28 or the $2 billion from your growth pillars stands excluding the contribution of past. And then secondly, you've previously talked about being well ahead of your 31% margin target, but I noticed you haven't really talked about that recently.

And obviously, you talked about 180 basis points of negative FX impact on tariffs over this year and over '25 and '26. Are you still well ahead of this target despite these headwinds? Or should we now assume that's not the case?

So we mentioned that, and I will also ask Roland to chime in at a point first of all, to your first question, the 7% CAGR. We gave that CAGR in June of 2024 in our CMD Capital Market Day in New York. You will agree with us that since 2024, the economic environment have become even more volatile, tariffs, volatility in currency evolutions geopolitical instability, funding difficulties for research and academia. Confronted with those difficult and volatile market condition, this is the role of management to take the necessary capital allocation to defend our growth profiles. And this is perfectly what is behind the acquisition of companies like Genoox and Parse, fully synergistic with our portfolio, accretive to our top line and financially accretive in a reasonable time frame.

So because our environment has worsened, it's fair to say that the 7% now fully include also the recent acquisition. If the market improves quicker, we might even beat that. But at the moment, let's focus and execute on the 7% all in. To the second question, Roland alluded to it, and I will also invite him to give his opinion. We believe we can beat the 31%.

At the same time, we say the market is still difficult around us. So let's see what could be a new guidance analysing different factors before we come to the market. Roland, on this point?

Yes. And again, just to give you some further thoughts to that. Again, as I said before, we clearly do expect that the growth in '26 is particularly driven by a very strong growth of our pillars of growth pillars of growth going to grow 9%. Same is going into high single-digit area. QIAstat nice significantly double-digit.

QIAcuity, significantly double-digit. QDI double digit as well. This is a high-margin product for us. So we will see an impact here as well. I do think, and again, also just looking at '25, it's a proof of evidence, right?

Sorry that we didn't know that the US is implementing tariffs. But if I exclude that and again, putting currency movement to the side, we gave out a target of $150 million, and we were achieving $200 million. Again, we were not -- just for a single year, that's a significant improvement. We're not standing still this year.

And I'm quite sure that we have for the operational efficiency program, a lot of things which we still can move. So it's not that we have to generate it. It's about execution. And I do think that is well that way. So yes, there will be something north of 31%.

I do think it's fair that also to say that we will take the time to announce that because alluding out -- we're in a management transition here. It doesn't mean that the guide the numbers are going to change, but I'd say it's also fair that whoever comes in has to review the number and has the opportunity to review this number and then we go to the market.

Understood, thank you.

Dan Brennan, TD Cowen.

Great, thank you. Thanks for the questions, Terry and Roland.

Maybe just first one, just back to QuantiFERON, if you don't mind. Just on the pricing comment Thierry, has this been consistent with what's been happening in the market over the last couple of years? Or is this kind of more of a newer strategy just to try to lock in some customers, maybe making some price concessions. Just wondering if you can kind of elaborate on that.

No, no, it's not a new strategy then. We disclosed that very transparently more than a year ago. We see an evolution of competition, and we need to fight also to make sure that we can move an already important base of customers who are -- that are in -- on a purely annual contract to more customers on contracts. So it's always a negotiation. We just disclosed last year that we need to be ready also to make some concessions.

But if it secures the deal for two or three years more, I think those are interesting concession. Obviously, they have to be reasonable. What I can guarantee you then is that overall, we continue to pass price increase every year on QuantiFERON as well. So if you look at the performance on pricing 2025 for QuantiFERON, it was positive. I was just saying that when it's necessary, we need to be flexible.

That's it.

Terrific. And then maybe just a follow-up. I know there was a question earlier backed on like strategic landscape, things like that, which I'm sure you're limited in what you could say. But maybe can you just speak to a little bit the market environment. You've been delivering on your plans and kind of ahead of plans in some cases for the '28 targets.

But when you look at like where the market sits today, you've got some pressure on academic and pharma, even though things might be getting better and unclear if customers want to deal with less players. So while you're executing when you think about Qiagen's ability to win or to be successful to create shareholder value as a stand-alone versus maybe maybe as part of a bigger company like has anything changed over the last year or two, just given the market dynamics?

We have all seen that that the market dynamic has been impacted by volatility and uncertainties over the last two years and three years, especially in research and academia, I think clinical has been a bit better. To your question, Qiagen has a clear plan for sales for our pipeline for new launches for profitability. We disclosed that plan in New York in June '24. And so far, we are executing as per this plan. This is where we focus.

Yes, the market has become more difficult. But as I said, we found also solution to continue to support our growth in addition to our organic growth. Those are the acquisition of very interesting technologies frankly or pass. We will continue to do that. Qiagen invest and will continue to invest on average between 9% to 10% of our sales into research and development.

This translates into launches of new products, 3 new systems, for example, in Sample tech this year. This is unprecedented. So it's clear that should laboratory in research and academia start again to invest in capital expense. We are coming with new solutions. Qiagen will probably will be 1 of their priorities.

This is what I can say is that the market has not been easier, more volatile, but the fundamentals of the market, both life science and clinical remains extremely strong. When we will have more visibility on economic evolution and funding, I think it's fair to say single-digit a mid-single-digit growth profile for this market is perfectly acceptable and realistic.

Doug Schenkel, Wolf Research.

Hey guys, thank you for taking my questions. One on guidance and then one on disclosure requirements. Simply put, I'm having a hard time getting the math to work. It could be me, but let's, for a second, assume it's not.

If we grow revenue around 5% reported, if operating margin remained flat net of deals, if we keep nonoperating items about flat year-over-year, and we reduced share count to $209 million, I think those are all your key guidance assumptions as well as you provided tax rate. If I put this together, you end up actually above $2.60 per share, if I'm doing the basic math, right, you guided to $2/50 or better.

What are we missing? So that's the first question. The second on disclosure requirements. Keeping in mind that you cited, I think it was German disclosure requirements as one 1 of the key reasons that you disclosed the plan when you did I'm wondering what would be the logical next required disclosure. Obviously, a new hire would need to be disclosed.

But is there anything else under regulations that you would likely have to disclose in advance of that event.

I do not want to disappoint you, on your numbers, but I do think you look like that some of your team is missing one number because one number of cost is significantly going to change with its net interest contribution because we clearly did an acquisition, we clearly did a significant share buyback program is $500 million.

So the net interest number is probably somewhere between $40 million and $45 million down. So that is all the number you are missing in your calculation. And yes, on disclosure requirement, again, is complicated. So luckily enough, I assume never becoming a lawyer and we're clearly working with our lawyers on this topic all the time.

Again, the general rule, if there's material news in the market regardless of which topic and you have the feeling that there is information in the market, which is clearly based on call it, lead information or change your share price into a significant extent.

The company has to comment on that. And that is regardless of any topic, right? And so I would say that is a framework. As I said, we typically leave these decisions to to judge and again, any kind of information if that is important, an event which we have to preannounce or not, you haven't seen anything from Qiagen so far.

That will conclude our question-and-answer session. At this time, I'd like to turn the call back over to Mr. Bernard for any additional or closing remarks.

Thank you very much. I would like to close this conference call and thank you for your participation. If you have any questions or comments, please do not hesitate to contact us. Thank you very much.

Ladies and gentlemen, this concludes the conference call. Thank you for joining and have a pleasant day. Goodbye.