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Operator
Ladies and gentlemen, good morning, and welcome to the CVS Health First Quarter 2021 Earnings Conference Call. (Operator Instructions) As a reminder, today's conference is being recorded.
I would now like to turn the call over to Katie Durant, Senior Director of Investor Relations for CVS Health. Please go ahead.
Katie Durant - Senior Director of IR
Thank you, and good morning, everyone. Welcome to the CVS Health First Quarter 2021 Earnings Call. I'm joined this morning by Karen Lynch, President and CEO; and Eva Boratto, Executive Vice President and CFO. Following our prepared remarks, we will host a question-and-answer session that will include Jon Roberts, Chief Operating Officer; Alan Lotvin, President, Pharmacy Services; Dan Finke, President, Healthcare benefits; and Neela Montgomery, President of Retail and Pharmacy.
Our press release and a slide presentation have been posted to our website, along with our Form 10-Q that we filed with the SEC this morning.
During this call, we will make certain forward-looking statements reflecting our current views related to our future financial performance, future events, industry and market conditions as well as the expected consumer benefits of our products and services, and our financial projections. Our forward-looking statements are subject to significant risks and uncertainties that could cause actual results to differ materially from what may be indicated in them.
We strongly encourage you to review the information in the reports we file with the SEC regarding these risks and uncertainties, in particular, those that are described in the cautionary statement concerning forward-looking statements and Risk Factors section in our most recent annual report on Form 10-K, this morning's earnings press release and included in our Form 10-Q.
During this call, we will use non-GAAP financial measures when talking about the company's performance and financial condition. In accordance with SEC regulations, you can find a reconciliation of these non-GAAP measures to the comparable GAAP measures in this morning's earnings press release and the reconciliation document posted on the Investor Relations portion of our website.
Today's call is being broadcast on our website, where it will be archived for one year. Now I would like to turn the call over to Karen.
Karen Sue Lynch - President, CEO & Director
Good morning, everyone, and thank you for joining our call today.
In what continues to be an unprecedented environment, CVS Health has delivered strong first quarter results. For all of us, the past year has been defined by the pandemic and our response to it. In the first quarter, CVS Health orchestrated an all-out effort to vaccinate Americans against COVID-19. I am proud to say we have helped achieve the President's accelerated 100-day goal of 200 million vaccines. This would not have been possible without the dedication and effort of our approximately 300,000 colleagues who worked tirelessly throughout the pandemic and delivered when they were needed the most.
Our results show we are providing superior value by creating an integrated health care model that is centered around the consumer. Our unparalleled capabilities, reach and relationship with customers uniquely positions us to support them throughout their lifetime.
Our strong first quarter delivered revenue growth of 3.5%. We generated adjusted earnings per share of $2.04, up nearly 7% versus first quarter of 2020. As a result, today, we are increasing our adjusted earnings per share guidance to $7.56 to $7.68 to reflect the momentum across our business. Importantly, our performance reflects both growth in new and current markets. Eva will provide more details on our outlook and our results.
Before turning to our 3 business segments, I'd like to underscore our ability to anticipate, deliver and exceed customers' health care expectations. Today, we will share where we are seeing momentum and highlight several important achievements. It is clear that consumers want convenience, transparency, choice and control over their health care. That is why we are engaging consumers in new and different ways by working to meet their health needs in the community, in the home and virtually.
Each of our businesses performed at or better than our expectations this quarter. We delivered strong results in the Health Care Benefits segment, fueled by continued growth in Government Services. During the first quarter, utilization approached near normal baseline levels. We have continued momentum in our Government Services business. We increased membership across all Medicare business lines in the first quarter. We outperformed with dual eligible members, delivering over 30% growth. And we significantly expanded our reach, adding 14 new states.
Finally, as we announced last quarter, we will reenter the public exchanges in 2022. We expect to enter up to 8 states where we believe we can make a meaningful impact and maximize returns with our first ever Aetna-CVS branded offerings. We are committed to helping provide access to affordable care for all Americans.
We also achieved strong revenue and operating income growth in Pharmacy Services, building on the foundation of our specialty management capabilities and overall service excellence. As we announced last week, we delivered market-leading results in controlling drug costs for commercial clients with only a 2.9% overall drug trend, with 34% of clients experiencing negative trend in 2020.
Specialty pharmacy revenue was up 7.2% year-over-year. This reflects new net wins due to our success in our trend management programs, which continued to resonate in the marketplace and drive more customers into our channels. Specialty pharmacy spend management also remains a steady growth engine and key differentiator in the market. We are well positioned for continued growth in 2022.
Our Retail segment continues to play a vital role in the delivery care and wellness, is an integral part of our customer and community strategy. Since we began, we successfully administered over 23 million COVID tests and over 17 million vaccines through April. We are currently administering vaccines in 49 states and in more than 8,300 CVS locations. 1/3 of vaccinations have been administered to members of underrepresented communities.
Our strong second dose compliance of over 90% is the result of our consumer-centric digital approach. We schedule round trip visits, booking both appointments at once. And we also provide appointments for second doses only. We are successfully driving health services engagement among customers who are new to CVS Health through COVID testing and vaccines. This has helped somewhat offset the impact of a weak flu, cough and cold season. Although early, we have seen improvement in April, as vaccinated customers are more actively shopping in CVS locations, part of a nationwide trend.
For those customers that are new to us through COVID testing, we have realized about a 9% conversion in filling a new prescription at CVS Pharmacy. We continue to attract consumers to our CarePass subscription program, with approximately 4.5 million members in total, up approximately 18% from 2020.
Building on the success of our employer and university program, we recently expanded our Return Ready offering to include vaccinations. We have already administered 40,000 doses, and client interest in this new service is strong and growing. Overall, we have successfully navigated through a challenging retail environment while capturing additional benefits from new customers we are bringing into CVS Health.
As the nation's leading diversified health services company, we're advancing our technology and using CVS Health assets to connect consumers across the health care ecosystem. We're addressing the most prevalent, costly and complex health conditions by expanding our platform to deliver more integrated care. Our approach combines both face-to-face and virtual points of care that are personalized to the individual. We prioritize the most valuable interventions, the next best action a member can take, that will lead to a positive impact on their health and on medical costs.
For example, early results in our Transform Diabetes program show an 8% improvement in changing Medicare members' behaviors. This program is on track to exceed its projected medical cost savings and return on investment of 2 to 1. With approximately 1.5 million members having access to this program today, we expect to add an additional 1.3 million members this year.
Our new medical benefit plans are designed with low co-pay or no co-pay at MinuteClinics. We have approximately 7 million Aetna members enrolled, up from about 2 million members or 350% member growth year-over-year. These plans offer broad access to affordable and convenient care with many CVS Health assets. First quarter results show Aetna commercial members are substantially more likely to use a MinuteClinic when enrolled in this type of plan compared to those without the benefit. In fact, these members are approximately 50% more likely to visit a MinuteClinic for an acute medical need, immunization or COVID test.
We also expanded our HealthHUB offerings to include new services around behavioral health, an increasingly important component of care, especially during the pandemic. Our strategy is to deliver a single integrated experience that connects individuals to a CVS care team, virtually and face-to-face, by navigating consumers to the best site of care.
We are a company focused on delivering the most convenient, connected experiences for our customers across our CVS Health digital assets. Our ability to redefine the health experience in an increasingly digital and hybrid world, combined with our vast health assets and understanding of consumers' health, uniquely positions us for growth.
There are 3 areas where I want to specifically highlight some of our achievements in the last quarter. They include: using our digital assets to expand engagement with our members; expanding into new services and offerings; and leveraging digital capabilities to enhance the customer experience and improve our cost structure.
Starting with engagement. We saw a more than 80% increase in visits to our flagship digital properties year-over-year. Growth was primarily driven by engagement in our expanded set of digital health services, such as COVID testing, vaccinations and omnichannel pharmacy.
Next, we are expanding access to care through our digital and virtual channels. We launched a digital-first primary care model that helps consumers navigate the best site of care for their health needs.
And lastly, we are also harnessing technology such as AI, machine learning services and natural language processing to simplify our process and optimize our cost structure. We recently announced the launch of our CVS Health venture fund that gives us insight into new digital health innovations. This approach allows us to invest in and partner with high-potential early-stage companies to drive technology-enabled innovation and digital health care.
Rising to meet the challenge of COVID-19 has advanced the transformation of the health care industry. For CVS Health, the chance to serve our nation at such a critical time has further proven the value of our strategy. We have made significant progress in the expansion of our vaccine and diagnostics businesses.
We are focused on building broader capabilities in home health, virtual care and health services. Our investments in these areas as well as our digital transformation have allowed us to be there for every meaningful moment of health and will enable us to capture the lifetime value of each of our customers.
And finally, we are exploring every avenue for growth and increased returns. Accordingly, we will hold our 2021 Investor Day on December 9, hopefully, in New York, conditions permitting, where the management team and I will more fully outline our longer-term strategic priorities and our financial road map for sustainable, profitable growth.
In closing, our results this quarter show that our strong brand and national presence is allowing us to meet individuals where they are. It makes us an increasingly integral part of their everyday health.
Now I'll turn it over to our Chief Financial Officer, Eva Boratto.
Eva C. Boratto - Executive VP & CFO
Thanks, Karen, and good morning, everyone.
As Karen stated, our strong performance across the enterprise continued in the first quarter. We delivered solid revenue growth of 3.5%, as a result of strong net new business plus the expansion of our successful COVID-19 testing and vaccine programs. Adjusted earnings per share of $2.04 increased 6.8% and exceeded our expectations.
Our cash flows remain strong, generating $2.9 billion of cash from operations. We paid down over $3 billion of long-term debt in the quarter, while returning $656 million to shareholders through dividends. Since the close of the Aetna transaction, we have paid down a net of more than $15 billion in long-term debt, and we remain on track with our low 3x leverage goal in 2022.
We are maintaining our discipline of capital allocation strategy and managing our balance sheet to generate additional cash flows. Across the company, we are executing on our modernization and cost savings initiatives, for which technology is at the core. As mentioned last quarter, we implemented an AI-enabled capability to efficiently address COVID-related calls. This intelligent agent addressed over 8 million calls for frequently asked questions. And we are expanding this technology to call centers across the enterprise.
We are also using AI and other technologies to simplify our prior authorization processes. We are decreasing the workload on providers and shortening the time it takes to get patients on appropriate therapy. This improves the overall patient experience while maintaining the clinical rigor, quality improvements and safety programs that are vital to our clients.
We have taken advantage of the increasing virtualization of work to rethink our infrastructure and are on track to close 63 non-retail facilities, resulting in a 2.5 million square foot reduction in office space by the end of Q2. We're pleased with our progress to date on these initiatives, and significant opportunity remains.
Now let's take a look at our results by segment. Our Health Care Benefits segment total revenues increased 6.7% year-over-year, driven by continued growth in our Government Services business. The repeal of the HIF and Medicare risk-adjusted revenue pressured that result. Total membership increased about 215,000 sequentially, with Medicaid membership up about 100,000 or 4%, driven by the continued suspension of eligibility redetermination and the new business win of Kentucky Foster's program effective January 1.
Our Medicare portfolio continues to grow, with Medicare Advantage and Med Supp membership increasing sequentially about 230,000, up over 6%. Within our PDP, membership increased nearly 4% sequentially. Converting existing commercial and PDP members to Medicare Advantage is one of our core growth strategies in Government Services. Included in these results are a sequential decline in commercial membership of about 120,000 members, driven by continued in-group attrition as well as the successful conversion of commercial to Medicare Advantage.
Our MBR for the quarter of 83.2% represents an increase of 80 basis points compared to prior year. While medical costs in the quarter were generally consistent with historical baseline levels in aggregate, the MBR was negatively impacted by the repeal of the HIF by approximately 140 basis points and lower Medicare risk-adjusted revenue. Offsetting these factors were the benefits from improved performance in Medicaid, which was pressured in Q1 of 2020, and prior year's development.
Of note, given the lower MBRs in 2020, portions of the prior year's development will be returned to clients and plan sponsors for contractual and regulatory requirements. Bringing these factors together, along with the impact of our cost reduction initiatives, adjusted operating income was $1.8 billion, up 19.5% year-over-year.
We are increasing our Health Care Benefits segment full year adjusted operating income guidance to $5.25 billion to $5.35 billion as a result of our performance to date and our current assumptions, including the extension of sequestration. Our guidance includes our best estimate of medical costs for the remainder of the year, with medical costs modestly elevated. This assumes non-COVID utilization returning towards normal baseline levels and continuing COVID costs, largely related to testing and the administration of the vaccine.
Now I'll move on to Pharmacy Services. Total revenues increased nearly 4% versus last year, primarily driven by net new business wins, specialty pharmacy growth and product mix. Brand drug price inflation of mid-single digits was in line with our expectations. Revenue continues to be negatively affected by price compression, as well as the weak cough, cold and flu season, which affected claims growth by approximately 230 basis points. We are through just over 65% of renewals for the 2022 selling season, with strong retention, including the retention of the retail and mail contracts with FEP and the return of FEP for specialty.
Adjusted operating income in Pharmacy Services increased 27.7% compared to the first quarter last year. This growth was fueled by improvements in purchasing economics, the ongoing benefits to our clients and CVS Health from the wrap of several specialty generic launches and our specialty trend management programs, which continue to drive value in the marketplace.
We are increasing our adjusted operating income guidance to $6.15 billion to $6.25 billion to reflect our performance to date and trends in the business, partially offset by the required investments to prepare to onboard the FEP specialty business in 2022.
And now let's review Retail/Long-Term Care. Before I get into the components of the P&L, let me start by discussing the effects of the weak cough, cold and flu season, which led to script and front store declines of approximately 300 basis points and 425 basis points, respectively. Overall, it drove about 40% of the adjusted operating income decline for the quarter.
Moving on to the P&L. Total revenues grew 2.3%, with scripts essentially flat year-over-year. COVID diagnostic testing and vaccine administration were accretive. The year-over-year revenue comparison includes the headwind from the acceleration of prescriptions and front store demand in March of 2020 as we served our customers and members at the start of the pandemic. During the quarter, we continued to gain share with an increase of 42 basis points.
Gross margins in the segment declined 30 basis points versus Q1 of 2020, driven by continued reimbursement pressure, mix of front and pharmacy revenues, partially offset by COVID-19 testing. Adjusted operating income declined 26.7% year-over-year, reflecting the items I have discussed as well as cost related to COVID-19 testing and long-term care vaccination program and severe weather-related cost in Q1 of 2021.
At this time, we are not changing our Retail/Long-Term Care segment guidance, as the benefit from the higher COVID-19 vaccine administration fee is offset by a slower than anticipated return of front store traffic and many unknowns such as urban market recovery and vaccine hesitancy.
Bringing all of the pieces together, we are increasing our 2021 adjusted earnings per share guidance to $7.56 to $7.68, up from our prior guidance of $7.39 to $7.55. Consistent with our prior guidance, COVID-19 is expected to have a minimal impact on consolidated financial results for the year. You can see further details of our changes in the slide presentation we posted to our website.
We continue to expect strong cash from operations between $12 billion and $12.5 billion. And our gross capital expenditure expectations remain at $2.7 billion to $3 billion to fund organic growth initiatives. We continue to expand our investments in technology and digital as we work on creating a seamless omnichannel consumer experience, bringing health care services to meet consumers' needs at the most appropriate time and place. Our enterprise cost savings initiatives are on track to generate $900 million to $1.1 billion, and these savings are expected to ramp as we move throughout the year.
Consistent with what we spoke about in February, we continue to expect our earnings cadence to be somewhat fluid over the course of the year. Based on our current estimates, which includes COVID-19 vaccines more heavily weighted to the front half of the year, we expect approximately 54% of our annual earnings per share in the front half.
In summary, we continue to meet the needs of our clients and consumers. This allows us to generate substantial cash to deliver on our financial commitments, to invest in our company and to return value to shareholders. We've executed against our growth commitments and are well positioned to deliver sustainable long-term growth.
Let's now open it up for your questions.
Operator
(Operator Instructions) We'll take our first question from Ricky Goldwasser with Morgan Stanley.
Rivka Regina Goldwasser - MD
Congratulations on a very good quarter. So my question is focused on the PBM segment. I mean, clearly, very strong performance, and really trying to understand the moving factors. You mentioned specialty and improved purchasing. So on the specialty side, maybe you can give us a little bit of more color on what are the specific products. It seems like you're alluding to biosimilar performance. So what type of adoption you're seeing?
And then also on the improved purchasing, there's a lot of questions we're getting from investors around generic pricing environment. So I wanted to see what you're seeing there.
Karen Sue Lynch - President, CEO & Director
Ricky, I'll start and I'll hand it off to Alan to give you more specifics. But as we mentioned, we continued to see very strong growth in the PBM business, really fueled by strong purchasing economics, the wrap of our specialty trend programs. And more importantly, you saw -- we've announced last week that we had really strong trend management with average trend of 2.9%, truly resonating in the marketplace.
The other thing I would mention, Ricky, is that the integrated value story between medical and pharmacy continues to resonate with our employer groups, and we've had strong success there. But let me turn it over to Alan, he can give you some more detail.
Alan M. Lotvin - Executive VP & President of CVS Caremark
Yes. So the -- as you think about kind of the economics across specialty, you sort of think about it in a couple of categories. So one is just generally improved purchasing economics across brands as well as generics, right? So that allows us to create greater value for our customers as well as meet all the obligations that we've created there. Then there -- successfully executing against programs that take advantage of the generics that launched late last year were also critically important, right?
So we were able to drive generic dispensing rates to levels that we -- a little bit higher than I think we initially thought. And that both benefits us as well as our clients. Those are the principal drivers of the economics within specialty. And then as Karen and Eva mentioned in their remarks, continuing to drive outstanding specialty trend is what allows customers to continue to choose us to manage their specialty spend as FEP did. So again, it becomes a self-reinforcing cycle.
Rivka Regina Goldwasser - MD
Great. And just a quick follow-up on the vaccine. Just to clarify, when you think about the vaccine benefit, clearly, you saw an improvement in reimbursement rates. Given that we're seeing some hesitancy around vaccine, and it seems that we might have seen a peak in growth there, are you now assuming a lower vaccine -- lower vaccines volumes for the year versus what you assumed in prior guidance?
Eva C. Boratto - Executive VP & CFO
Ricky, this is Eva. I'll take that one. Overall, as you said, recently, we have seen some vaccine hesitancy. We've seen a drop-off of around 30%, as you look at some of the recent data there. The initial -- the initial outlook we had provided was it was about a 2% to 3% contributor to our overall volume growth. Right now, we're probably trending at the lower end of that range given performance to date and what we're seeing in the market. In our outlook, we are assuming the pediatric vaccine. But what's not included in our current estimates is the impact of a booster should there be one later this year or...
Operator
We'll go to Steven Valiquette with Barclays.
Steven James Valiquette - Research Analyst
So within the HCB or Aetna segment, the MLR came in better than expected. There also seems to be some investor focus on the better than expected SG&A, which was within that segment as well. So I'm curious if you can speak to some of the operating expense.
Karen Sue Lynch - President, CEO & Director
Steve, we're having a hard time hearing you. So I wonder if you could speak up.
Steven James Valiquette - Research Analyst
Is this any better?
Karen Sue Lynch - President, CEO & Director
Much better. Thank you.
Steven James Valiquette - Research Analyst
Okay. So I'm not sure what happened there, so I apologize. My question was just on the HCB or Aetna segment. The MLR came in better than expected, but there also seem to be some investor focus on better than expected SG&A within that segment as well. So I was curious if you're able just to speak to the operating expense trends within Aetna. And also, if I missed it, if you gave the prior year development number, just to have that handy as well within HCB.
Karen Sue Lynch - President, CEO & Director
Yes. I'll start, and I'll hand it to Eva for prior period development. On the cost -- on the expenses for Aetna last year, and we continue to do this every year, is to continue to look for ways to improve our overall cost efficiency. We embarked on initiatives last year using technology, looking at ways we can be more competitive. And that's reflected in the first quarter results in the segment. And as you might expect, we continue to do that across the company, as I mentioned in my prepared remarks. We, every year, continue to look at ways to become more efficient and we are really trying to harness technology to make those efficiencies real. And the health care benefit really did see the effects of that in the quarter.
Eva, do you want to talk about the prior period development?
Eva C. Boratto - Executive VP & CFO
Sure, Karen. Thanks. Overall, we did experience elevated prior year development in the quarter. However, when you look at it on a financial statement net basis, given the MLR, MBR contractual requirements, I would say it's really not that unusual compared to prior years.
Operator
We'll go now to Lisa Gill with JPMorgan.
Lisa Christine Gill - MD, Head of U.S. Healthcare Technology & Distribution Equity Research and Senior Research Analyst
Karen, I want to go back to your earlier comment when you talked about behavioral health and connecting the consumer with the best site of care. Can you talk about how you're doing that, specifically? How you're contracting with behavioral health specialists? If these are psychiatrists or psychologists? And how that really feeds into a broader comment that you made around the consumer talking about the home virtual community? How do I think about all those elements working together when we think about both mental health and physical health?
Karen Sue Lynch - President, CEO & Director
Well, I think relative to behavioral health, it is critically important for us to focus on it. The pandemic has increased the number of behavioral health interactions. And I think what we've seen in the -- with individuals, we've seen increases in substance abuse. We've seen increases in domestic violence. We've seen increases in depression and anxiety.
What we've done is we have put licensed clinical social workers in a certain number of our HealthHUBs. And what we are trying to do is really connect the physical health with the mental health. In every single MinuteClinic, we do behavioral health screenings. They then will be referred to our licensed clinical worker that is in the facility in the HealthHUB. And then we can connect with them digitally as well through our e-clinic capabilities.
And we are actually seeing very strong results in this program. We're seeing 3 visits in a month from those individuals that have already engaged with us. So clearly, there's a need to make those connections. It is a differentiator for us and something that I believe is important as you think about mental health and physical health combining to take care of the holistic person and then meeting them where they want to be met.
Quick customer story, Lisa. We had an individual reach out to us. She was trying to get into see behavioral health provider, she couldn't. And when she -- took her a month, and then after a month, they told that it would take another month for her to get an appointment. She learned about CVS Health, and we got her in the same day. So there is definitely a need. And I'm very excited about the possibilities for us to really enhance our products and services to support the holistic health of individuals.
Lisa Christine Gill - MD, Head of U.S. Healthcare Technology & Distribution Equity Research and Senior Research Analyst
And how do we think about that like from a financial perspective, Karen? Is this that these are Aetna members and, therefore, you're going to be able to lower overall health care costs for that member because we keep them well both mentally and physically? Or is this a program where you're charging fees for service to other plan members? And is it -- this going to be a big enough driver? And is there an attachment rate to this? Just how do we think about some of the opportunities around that?
Karen Sue Lynch - President, CEO & Director
Yes. The way to think about -- and I'll hand it over to Neela, we -- it's broader than just Aetna because we have contracts with other managed care plans. So they are coming in. It is part of the -- their insurance coverage, and that's how kind of the economics of it. Let me ask Neela to talk a little bit more in detail.
Neela Montgomery - Executive VP & President of Pharmacy and Retail
I would say that we are using insurance at the moment, and that's the main way in which people are accessing care. As Karen mentioned, access is a huge factor, and the convenience of evenings and weekends in our proposition makes it very desirable to customers. Over time, we do expect to grow the sort of D2C fee-for-service business because we do recognize that's a large part of the market, and we expect to launch that next month.
Operator
Our next question comes from A.J. Rice with Crédit Suisse.
Albert J. William Rice - Research Analyst
Just to start out, I really appreciate the comments about how Aetna is integrating with MinuteClinic and HealthHUBs for new product offerings. That seems like the principal way the 3 businesses are maybe integrating. But I wonder, 2 years into the deal, are there other things you'd highlight as to why the 3 individual businesses are better all together and things you've realized from the deal that may be worth highlighting some people beyond that?
Karen Sue Lynch - President, CEO & Director
I think there are a number of things. You mentioned MinuteClinic. I would say the integration of medical pharmacy is another area. We've also put out a number of clinical programs that we are advancing as part of the overall combination of the 3 companies: our diabetes program, our chronic kidney program, our oncology program. All those programs demonstrate the value of an integrated offering where we have those programs, and we can meet people either in the MinuteClinics or we can meet them at home, and obviously manage their insurance coverage.
So there are a number of different proof points. We're also leveraging technology and analytics through our next best action. And then I would say our new programs like our Return Ready program is another demonstrable impact of having a combined company where we have the ability to sell our testing and our vaccine programs to our employer groups and then engage them in their sites or in our MinuteClinic. So a number of things that I would point to that demonstrates the value of the combined 3 companies.
Albert J. William Rice - Research Analyst
Okay. Maybe just a quick additional question. On the -- we're seeing a lot of the companies in the sector pursue service -- incremental service opportunities through acquisition. I know you guys are still highlighting a priority for capital deployments just to continue to reduce debt. But how should we think about your interest in some of the service line extension, provider extensions that we're seeing others do? Is that of interest to you? How do you -- how should we think about that?
Karen Sue Lynch - President, CEO & Director
Yes. A.J., thank you for the question. It -- obviously, you mentioned our first and foremost priority is capital deployment to pay down debt. But clearly, we are looking at all of our options around additional services, as demonstrated by our virtual care offerings and things like that. But yes, that is something that would be of interest to us.
And let me turn it over to Eva.
Eva C. Boratto - Executive VP & CFO
Thanks, A.J. What I'd add to Karen, certainly paying down our debt remains a top priority. Additionally, I'd remind you that, in the outlook provided, we did provide for what I'll call smaller M&A to fill out the businesses and where there are needs. And we continue to invest organically as well in terms of our CapEx spending and building out the services and capabilities to drive the business forward.
Operator
Our next question comes from Michael Cherny with Bank of America.
Michael Aaron Cherny - Director
I wanted to dive a little bit back into some of these sourcing dynamics that you're seeing. As you think through the component, in particular, on both generics and specialty, you called it out for the Pharmacy Services segment as a whole. How does that factor in across the entire enterprise? And how should we think about the durability, especially given that you're easily the largest purchaser in the world of drugs on some of these ongoing sourcing efficiencies, especially in a world where generics as a whole are pretty close to 90% of the total market?
Eva C. Boratto - Executive VP & CFO
Mike, it's Eva. Thanks for the question. Overall, we source our generics consistently for the entire enterprise, whether it's the Retail/Long-Term Care segment or the PBM segment. And obviously, there have been some specialty generics launches that we've been able to optimize the benefit of that given our size and scale and our capabilities within the company. I would just remind you the economics of specialty manifest themselves on the PBM segment with our Specialty Connect program. And so you'll see the benefits from that program there.
And I think to your question around durability, right, we do see new generics continuing to come to market, availability of biosimilars to provide longer-term benefits. And Alan will provide a little bit more color on that.
Alan M. Lotvin - Executive VP & President of CVS Caremark
Yes, Michael, if I could just add. As you know, specialty is somewhere north of 50% of the total drug spend right now. And given the evolution of the FDA around substitutability biosimilars as well as traditional generics for older small molecules, the specialty business is sort of entering that phase of increased competition. So as we look forward over the next 2, 3, 4 years, we see a very robust pipeline of both generics and biosimilars and specialty, which while, to your point, the generic dispensing rate is now 90%, given the dollar volume is still largely in specialty creates ongoing opportunity for us.
Michael Aaron Cherny - Director
Just one more really quick question. I know you don't guide quarterly, but what's implied on the next year's cough, cold, flu season in terms of how to think about the trajectory of the business since the end of the year?
Karen Sue Lynch - President, CEO & Director
Mike, if I could predict the cough, cold season, that would be a great skill to have. But what I'd say is, as you look, we are assuming the economy continues to return to normal levels as people are vaccinated. What happens with the cough, cold, flu season will affect the segments differently. Obviously, lower medical cost if it's a weak cough, cold, flu season again, and lower scripts on the Retail/Long-Term Care segment. So overall, I think about it at a more normal-ish level. But when there's variability, it will affect the different segments differently.
Operator
Our next question comes from Eric Percher with Nephron Research.
Eric R. Percher - Research Analyst
Eric and Josh Raskin here. A question on the Retail segment and pharmacy reimbursement pressure. As we enter a new year, we always see a comment on reimbursement pressure. And I know that there have been strategies to drive volume or increase Pharmacy Services, and of course, integrated opportunities. But when you look at reimbursement pressure itself, does it remain the same type of headwind that it has over prior years? And what are the strategies you've implemented that can offset that actual reimbursement pressure?
Karen Sue Lynch - President, CEO & Director
A couple of things on reimbursement. We recognize that this continues to be a challenge for us. And what we are currently working on are revising our contracting strategies, continuing to manage cost initiatives and clearly managing our supply chain in an appropriate way. As I mentioned on the call, we're exploring all of our options here, and I think we'll have more to talk about in December.
And let me just see if Eva has anything to add here.
Eva C. Boratto - Executive VP & CFO
As Karen said, Eric, right, we have volume, we have cost, and we have Red Oak to continue to unlock value. As you saw, we're looking on the cost front beyond the purchasing side. We're looking at ways to continue to reduce operating cost in our operations, utilizing technology and really trying to lower the cost.
Eric R. Percher - Research Analyst
And on the biosimilars side, when we see the sourcing benefits, is that, in part, reflecting success with the new Zinc entity? Or does that fall into Red Oak?
Alan M. Lotvin - Executive VP & President of CVS Caremark
So biosimilars would flow through our traditional Caremark contracting. Part of that was -- is within Zinc and part of that is directly through Caremark, not through Red Oak.
Operator
We'll go now to Bob Jones with Goldman Sachs.
Robert Patrick Jones - VP
Maybe just to go back to the HCB segment and the strong performance there and the subsequent guidance raise of $150 million at the midpoint. I know there's, obviously, a number of moving pieces that inform the guidance. But I was hoping maybe you could just break out and talk a little bit specifically about the sequestration extension. And how maybe any updated views on utilization help inform that raise for the full year?
Eva C. Boratto - Executive VP & CFO
Bob, it's Eva. And as you said, we delivered strong performance in the quarter, and our outlook remains strong. So I'll try to give you 4 key pieces what we reflected in that outlook. Our performance to date, and I commented earlier the benefits from prior year's development. Think about that generally on a net basis, not that different from what we've seen previous years given where MBRs were for 2020 and our client and contractual requirements. We have included sequestration through the end of the year.
And as you think about medical costs, we've updated our medical cost assumptions for 2 areas. One, we continue to incur COVID-related costs, driven largely by testing and vaccine spend. And those costs are at lower levels than the first half of the year, given as people become immunized, the treatment costs we expect to decline. As it pertains to non-COVID utilization cost, we expect it to return to more normal seasonal baseline levels, particularly in the second half. And our outlook for membership remains consistent with what we provided previously.
Robert Patrick Jones - VP
Great. That's helpful. I guess just one quick follow-up within HCB around the decision to get back into the exchanges in a more meaningful way. Any updated thoughts or latest thoughts on the strategy, kind of what the go-to-market will be? Who you'll be targeting within the exchanges relative to some of the other offerings out there? That would be helpful to get your latest thoughts on that.
Karen Sue Lynch - President, CEO & Director
Bob, it's Karen. First, I would say that we -- given that we're entering into the exchanges, that's a market that we have 12 million to 15 million people that we don't have access to today. We are clearly going to offer an Aetna-CVS branded product. We will continue to have our narrow networks. And we are in the midst of filing rates. So I don't want to give too much competitive insight or information.
And let me see if Dan Finke has anything else he wants to add here.
Daniel Philip Finke - Executive VP & President of Health Care Benefits Segment
Sure. Thanks, Karen. So as Karen said, we're excited about the opportunity to enter the individual market. We are in the middle of the filings. As Karen stated, we're taking a really disciplined and deliberate approach to selecting those states. One of our opportunities is really to connect our strategies around the use of CVS assets. And so we're really looking forward to opportunities around our digital and physical assets, enhancing some of our pharmacy support with those offerings, and of course, giving access to our MinuteClinics and our HealthHUBs. And so we're really excited to bring this new and different offering to the marketplace.
Operator
Our next question comes from Justin Lake with Wolfe Research.
Justin Lake - MD & Senior Healthcare Services Analyst
First question, I just want to follow up on the PBM outperformance. It's been pretty incredible over the last 3, 4, 5 quarters. I know your purchasing is very strong there, but not seeing the same performance at your peers. I'm wondering if there's anything you feel like you're doing differently in terms of that generic specialty opportunity, your purchasing with Zinc, et cetera, that might be allowing for that outperformance versus your peers here?
Alan M. Lotvin - Executive VP & President of CVS Caremark
It's Alan. Thank you for the question. The -- I think the key drivers here are paying really close attention to creating competition, right, to driving more value for our customers, which enables us to bring on more volume. I think one of the things that we should also talk -- let's talk about 2 things, right? So first is the purchasing and the performance around generics and specialty agents. The second is, we have a good portion of our business is what we would call open market where there's choice. We're very aggressive in talking about the benefits to members and patients from an experience perspective of both Specialty Connect and Specialty Expedite.
And -- so that's, again, an example of how we use the entire enterprise to create better experiences and ultimately more value because it drives volume. So it's a combination of volume. It's a combination of attention to detail and performance on the generic side. And it's, as you said, purchasing economics that continue to drive and look for opportunities where we can create more competition to drive more value.
Eva C. Boratto - Executive VP & CFO
Sorry, Justin, it's Eva. Alan, just to add, your performance overall remains very strong. We had a very strong welcome season this year, and client satisfaction remains high, which, Justin, as you know, in the PBM sector is critical.
Justin Lake - MD & Senior Healthcare Services Analyst
Sure. And then just a quick follow-up on the transformation targets you laid out with the deal. Those are expected to be a big benefit for 2022. So I was hoping to get some -- any kind of updated color on HealthHUBs versus the 1,500 target. And how you feel about that transformation number of 850 as you kind of look ahead to next year?
Karen Sue Lynch - President, CEO & Director
Justin, I'll comment on the HealthHUBs and Eva can give the transformation update. Just on HealthHUBs, we have about 800 HealthHUBs now. We built about 250 during the quarter. We do expect to get to about 1,000-ish by the end of the year.
What I would tell you, I'm not really looking at the number. I'm looking at coverage. I think coverage is the more important metric here. And right now -- by the end of the year, it will be 60% coverage on the Aetna Caremark business, will be about almost 50% of the U.S. population. So that's really how I think about the hubs and where we -- how we get coverage versus the exact number.
Eva C. Boratto - Executive VP & CFO
And Justin, on the transformation, you heard throughout Karen's comments and some of the proof points that we brought, I would say how we're unlocking value is: a, focusing on driving medical cost savings; 2, our ability to win new lives in the marketplace by having these differentiated products and services; and continuing to sell into new customers and in an open market type of way. So as you look specifically, we're pleased with how transformation is running. And as Karen said, we'll outline more at our December Investor Day.
Operator
We'll go to Lance Wilkes with Bernstein.
Lance Arthur Wilkes - Senior Analyst
Could you just talk a little bit about the omnichannel strategy, in particular, in the home health or the home focus? What sort of populations and offerings are you looking at there? And then just maybe secondarily, just asking about how you're going to organize these efforts and manage them within the company? Is HealthHUB home and virtual are all going to be managed together? Or how are you going to work that out as well?
Karen Sue Lynch - President, CEO & Director
Well, Lance, on the operating model, we continue to evaluate the best approach to managing our business, and more to come on that.
Let me ask Alan to talk about our home strategy as he's developing our overall home services strategy.
Alan M. Lotvin - Executive VP & President of CVS Caremark
Yes. So it's Alan. The -- as we think about home, I think about home as a really important channel as part of that evolving care delivery, right? We've seen a change in how people expect to receive many things after the pandemic, including care. So as we think about it, it's how do we create products and services that are either partly or entirely delivered in home, that help us both differentiate on the medical cost savings side, create new experiences for customers or take advantage of specific technologies.
So whether it's our home dialysis program, which is in process, our quorum or new virtual care products that support specific populations, that's how we're thinking about home. But it's about meeting the customer need or the member need first rather than focusing explicitly on a channel and how do we integrate across all of the touch points we have, whether they're digital, virtual, physical in the home or local.
Lance Arthur Wilkes - Senior Analyst
Great. And just understanding it, for the home aspect, obviously, infusion and some of the drug-specific opportunities present themselves there. In addition, there's kind of a stabilization that might be important for an MA population like home health, and there's the emerging spaces and kind of frail elderly with physicians. As you're talking about home, are you thinking about one area over another as far as your areas of focus?
Alan M. Lotvin - Executive VP & President of CVS Caremark
So Lance, I'm sorry, I wasn't clear enough. So when we think about specific population, exactly the populations you're talking about, people transitioning out of the hospital who are frail, keeping them out of the hospitals, keeping them out of skilled nursing facilities by using more virtual services and physical services in the home are a core population. That's an example of how we would enable, for example, the Health Care Benefits business to be more effective at managing their risk. So that's exactly a population we'd be looking at, in addition to the ones you traditionally expect us to look at like drug and dialysis.
Karen Sue Lynch - President, CEO & Director
Before we conclude today, I'd like to leave you with 3 points that I hope you took away from the call.
First, our integrated health care model is unique, and it is driving growth. You can clearly see that in our financial results across our business, but you can also see it in different ways that we're interacting with our customers.
Secondly, you -- we are increasingly using digital and technology to redefine the health experience and to improve our cost structure. And finally, we are making significant progress and are well positioned to deliver growth against our strategy.
So thank you all for joining us today.
Operator
This concludes today's CVS Health First Quarter 2021 Earnings Call and Webcast. You may disconnect your line at this time. Have a wonderful day.